4-[4-(4-Fluorophenyl)-6-oxo-3-phenyl-1H,4H,5H,6H-pyrrolo[3,4-C]pyrazol-5-YL]benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[4-(4-Fluorophenyl)-6-oxo-3-phenyl-1H,4H,5H,6H-pyrrolo[3,4-C]pyrazol-5-YL]benzoic acid
• 英文别名: 4-[4-(4-fluorophenyl)-6-oxo-3-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoic acid
• 化学式: C₂₄H₁₆FN₃O₃
• 分子量: 413.4
• InChiKey: JLYMUDGOIIEHMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  86.3
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SCREENING METHODS FOR IDENTIFYING PLASMODIUM PROTEASES INHIBITORS
  申请人：Institut Pasteur

  公开号：EP2646568B1

  公开（公告）日：2019-05-29
• US9404142B2
  申请人：——

  公开号：US9404142B2

  公开（公告）日：2016-08-02
• [EN] SCREENING METHODS FOR IDENTIFYING PLASMODIUM PROTEASES INHIBITORS<br/>[FR] PROCÉDÉS DE CRIBLAGE POUR L'IDENTIFICATION D'INHIBITEURS DE PROTÉASES DE PLASMODIUM
  申请人：PASTEUR INSTITUT

  公开号：WO2012073066A1

  公开（公告）日：2012-06-07

  The invention relates to the field of parasitology. Methods and peptidic substrate for screening and identifying inhibitors of Plasmodium are described. Also described are compounds identified by these screening methods, including more particularly inhibitors of Plasmodium subtilisin-like proteases. The invention also concerns anti-malaria compounds, anti-malaria compositions, and uses thereof for preventing, treating, improving, and/or alleviating a Plasmodium infection in a subject, and more Plasmodium vivax and/or by Plasmodium falciparum human infections.