O-ethyl O-(3,5,6-trichloro-2-pyridyl) O-(3-carboxypropyl) phosphorothioate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: O-ethyl O-(3,5,6-trichloro-2-pyridyl) O-(3-carboxypropyl) phosphorothioate
• 英文别名: o-Ethyl o-(3,5,6-Trichloro-2-pyridyl) o-(3-Carboxypropyl)Phosphorothioate；4-[Ethoxy-(3,5,6-trichloropyridin-2-yl)oxyphosphinothioyl]oxybutanoic acid；4-[ethoxy-(3,5,6-trichloropyridin-2-yl)oxyphosphinothioyl]oxybutanoic acid
• 化学式: C₁₁H₁₃Cl₃NO₅PS
• 分子量: 408.627
• InChiKey: UCUQEGGTUGPCGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3,5,6-三氯吡啶-2-醇 在 氢溴酸 、 溶剂黄146 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 27.0h， 生成 O-ethyl O-(3,5,6-trichloro-2-pyridyl) O-(3-carboxypropyl) phosphorothioate
  参考文献：
  名称：

  Development of Enzyme-Linked Immunosorbent Assays for the Insecticide Chlorpyrifos. 1. Monoclonal Antibody Production and Immunoassay Design

  摘要：

  The present work describes the production and characterization of monoclonal antibodies (MAbs) to the insecticide chlorpyrifos and their incorporation into several ELISA configurations. With this aim, a collection of chlorpyrifos haptens was synthesized by introducing appropriate spacers in opposite sites of the analyte molecular structure. From mice immunized with protein conjugates of these haptens, several hybridomas secreting MAbs with the ability to sensitively bind the analyte were obtained. IMAbs showing the highest affinity to chlorpyrifos in homologous assays (I-50 values in the 20-220 nM range) were selected. Hapten heterology involving modifications of the moiety closer to the attachment site provided the highest improvement in sensitivity. MAbs displayed striking differences in their cross-reactivity pattern with structurally related compounds. One MAb (I-50 around 10 nM) was incorporated into other ELISA formats. No remarkable changes of assay characteristics, other than immunoreagent consumption and immunoassay procedure, were found. These ELISAs are potentially very valuable analytical tools for the rapid and sensitive determination of this insecticide.

  DOI：

  10.1021/jf960144q

文献信息

• PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS
  申请人：Seattle Children's Hospital (dba Seattle Children's Research Institute)

  公开号：US20200087399A1

  公开（公告）日：2020-03-19

  Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.