ethyl-2-phenyl-1-benzenecarboximidate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl-2-phenyl-1-benzenecarboximidate
• 英文别名: ethyl [1,1'-biphenyl]-2-carbimidate；Ethyl 2-phenylbenzenecarboximidate；ethyl 2-phenylbenzenecarboximidate
• 化学式: C₁₅H₁₅NO
• 分子量: 225.29
• InChiKey: JQZYVNRSQYLZPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  methyl 2,3-diaminopropionate hydrochloride 、 ethyl-2-phenyl-1-benzenecarboximidate 以 乙醇 为溶剂， 反应 168.0h， 以24%的产率得到methyl 2-(2-biphenyl)-4,5-dihydro-1H-5-imidazolecarboxylate
  参考文献：
  名称：

  Expeditious Synthesis of 2-Aryl Substituted Imidazolines and Imidazoles

  摘要：

  A versatile and efficient method for the synthesis of 2-aryl substituted imidazolines and imidazoles bearing a carboxylate group on C-4 is reported. Three different synthetic pathways were explored, compared and optimized. The selected procedure involves condensation of methyl 2,3-diaminopropionate with different imino ethers. The ring closure, monitored by LC-MS analysis, was facilitated by heating at reflux in ethanol leading to increase the rate of cyclization.

  DOI：

  10.3987/com-06-10708
• 作为产物：
  描述：

  二氢-3-(异十二碳烯基)呋喃-2,5-二酮 在 吡啶 、 碳酸氢铵 、 二碳酸二叔丁酯 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 48.0h， 生成 ethyl-2-phenyl-1-benzenecarboximidate
  参考文献：
  名称：

  Expeditious Synthesis of 2-Aryl Substituted Imidazolines and Imidazoles

  摘要：

  A versatile and efficient method for the synthesis of 2-aryl substituted imidazolines and imidazoles bearing a carboxylate group on C-4 is reported. Three different synthetic pathways were explored, compared and optimized. The selected procedure involves condensation of methyl 2,3-diaminopropionate with different imino ethers. The ring closure, monitored by LC-MS analysis, was facilitated by heating at reflux in ethanol leading to increase the rate of cyclization.

  DOI：

  10.3987/com-06-10708

文献信息

• Controllable Rh(III)-Catalyzed C–H Arylation and Dealcoholization: Access to Biphenyl-2-carbonitriles and Biphenyl-2-carbimidates
  作者：Bo Jiang、Songxiao Wu、Jing Zeng、Xiaobo Yang

  DOI：10.1021/acs.orglett.8b02915

  日期：2018.10.19

  A controllable Rh(III)-catalyzed C-H arylation and dealcoholization of benzimidates with arylboronic esters was developed, delivering various biphenyl-2-carbonitriles and biphenyl-2-carbimidates by simply tuning the reaction conditions. This approach features high efficiency, good functional group tolerance, and easy operation. It also provides an alternative pathway to thoroughly exploit the directing group in transition-metal-catalyzed C-H activations.
• Expeditious Synthesis of 2-Aryl Substituted Imidazolines and Imidazoles
  作者：Sylvia Lauwagie、R使is Millet、Jean Pommery、Patrick Depreux、Jean-Pierre H始ichart

  DOI：10.3987/com-06-10708

  日期：——

  A versatile and efficient method for the synthesis of 2-aryl substituted imidazolines and imidazoles bearing a carboxylate group on C-4 is reported. Three different synthetic pathways were explored, compared and optimized. The selected procedure involves condensation of methyl 2,3-diaminopropionate with different imino ethers. The ring closure, monitored by LC-MS analysis, was facilitated by heating at reflux in ethanol leading to increase the rate of cyclization.