(S)-leucyl-(R)-α-methyl-4-carboxyphenylglycine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-leucyl-(R)-α-methyl-4-carboxyphenylglycine
• 英文别名: 4-[(1R)-1-[[(2S)-2-amino-4-methylpentanoyl]amino]-1-carboxyethyl]benzoic acid
• 化学式: C₁₆H₂₂N₂O₅
• 分子量: 322.361
• InChiKey: IONCAQVBEONTHF-BLLLJJGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-(4-methyl-2,5-dioxoimidazolidin-4-yl)benzonitrile 在 盐酸 、 三乙胺 作用下， 以 吡啶 、 溶剂黄146 为溶剂， 反应 384.5h， 生成 (S)-leucyl-(R)-α-methyl-4-carboxyphenylglycine
  参考文献：
  名称：

  Resolution and regioselective protection of glutamic acid analogues. II- Synthesis, resolution and configuration assigsment of (+)-α-methyl-4-car☐yphenylglycine (M4CPG)

  摘要：

  Diastereomeric dipeptides (S)-Leu-(S)-M4CPG and (S)-Leu-(R)-M4CPG have been synthesized from (+/-)-M4CPG and separated by anion exchange chromatography. Absolute configuration of (S)-(+)-M4CPG was assigned by X-Ray crystallography of (S)-Leu-(S)-M4CPG. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0957-4166(96)00387-4

文献信息

• Resolution and regioselective protection of glutamic acid analogues. II- Synthesis, resolution and configuration assigsment of (+)-α-methyl-4-car☐yphenylglycine (M4CPG)
  作者：Elisabeth Coudert、Francine Acher、Robert Azerad

  DOI：10.1016/0957-4166(96)00387-4

  日期：1996.10

  Diastereomeric dipeptides (S)-Leu-(S)-M4CPG and (S)-Leu-(R)-M4CPG have been synthesized from (+/-)-M4CPG and separated by anion exchange chromatography. Absolute configuration of (S)-(+)-M4CPG was assigned by X-Ray crystallography of (S)-Leu-(S)-M4CPG. Copyright (C) 1996 Elsevier Science Ltd