diethyl 2-allyl-2-(1'-ethoxyprop-2'-en-1')malonate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: diethyl 2-allyl-2-(1'-ethoxyprop-2'-en-1')malonate
• 英文别名: Diethyl 2-(1-ethoxyprop-2-enyl)-2-prop-2-enylpropanedioate
• 化学式: C₁₅H₂₄O₅
• 分子量: 284.353
• InChiKey: ZLMHBPSPXGHWBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  烯丙基丙二酸二乙酯 、 5-(1'-ethoxyprop-2'-en-1'-yl)-2,2,5-trimethyl-1,3-dioxane-4,6-dione 在 四(三苯基膦)钯 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以54%的产率得到diethyl 2-allyl-2-(1'-ethoxyprop-2'-en-1')malonate
  参考文献：
  名称：

  Palladium-catalyzed substitution of acrolein acetals by β-dicarbonyl nucleophiles

  摘要：

  beta-Dicarbonyl compounds with a high acidity (pKa < 8-9) easily react with acrolein diethyl or dimethyl acetals in the presence of a palladium catalyst and lead to allyl ethers. Some of these can be thermodynamically isomerized to enol ethers during their purification or substituted by another soft carbonucleophile under similar conditions, because of the leaving group property of the enolate of these stabilized beta-dicarbonyl unit. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00648-6

文献信息

• Palladium-catalyzed substitution of acrolein acetals by β-dicarbonyl nucleophiles
  作者：Nicolas Vicart、Jacques Goré、Bernard Cazes

  DOI：10.1016/s0040-4020(98)00648-6

  日期：1998.9

  beta-Dicarbonyl compounds with a high acidity (pKa < 8-9) easily react with acrolein diethyl or dimethyl acetals in the presence of a palladium catalyst and lead to allyl ethers. Some of these can be thermodynamically isomerized to enol ethers during their purification or substituted by another soft carbonucleophile under similar conditions, because of the leaving group property of the enolate of these stabilized beta-dicarbonyl unit. (C) 1998 Elsevier Science Ltd. All rights reserved.