(3E)-3-butylidene-7-hydroxy-2-benzofuran-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: (3E)-3-butylidene-7-hydroxy-2-benzofuran-1-one
• 化学式: C₁₂H₁₂O₃
• 分子量: 204.22
• InChiKey: XLFDJKJEYMKLJX-JXMROGBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Combination therapy for treatment of patients with neurological disorders and cerebral infarction
  申请人：Moleac Pte Ltd.

  公开号：EP2508191A1

  公开（公告）日：2012-10-10

  The present invention provides compositions and methods of treating a patient having a condition selected from the group of cerebral stroke, heart stroke, neurodegenerative diseases, brain or nervous system trauma, or neuroplasticity wherein the composition comprises: (i) at least 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 of: Radix Astragali (milkvetch root or Huang Qi); Rhizoma Salviae Miltiorrhizae root (red sage or Dan Shen); Radix Paeoniae Rubra (red peony or chi shao); Ligusticum Chuanxiong (Chuan Xiong); Rhizoma Notoginseng (Sanqi); Odoriferous Rosewood (Jiang Xiang); Scorpion (Quan Xie); Radix Polygalae (Yuan Zhi); Grassleaf sweetflag (Shi Changpu); Leech (Hirudo or Shuizhi); Ground beetle (Tu Bie Chong); Cow bezoar (calculus Bovis artifactus or Rengong Niuhuang); Gambirplant (ramulus uncariae cum uncis or Gou teng); and (ii) an agent used in Western medicine.

  本发明提供了治疗选自脑中风、心脏中风、神经退行性疾病、脑或神经系统创伤或神经可塑性疾病的患者的组合物和方法，其中组合物包括：(i) 至少4、5、6、7、8、9、10、11、12、13或14种：黄芪；丹参；赤芍；川芎；三七；紫檀；全蝎；蝎子（全蝎）；远志（远志）；草叶甘草（石菖蒲）；水蛭（葫芦或水芝）；地鳖虫（土鳖虫）；牛黄（牛黄结石或人参牛黄）；钩藤（钩藤或钩藤瘤）；以及 (ii) 西药中使用的制剂。
• Anti-tumor traditional Chinese medicine microbial fermentation preparation and a preparation method and application thereof
  申请人：Li Xingyao

  公开号：US10987389B2

  公开（公告）日：2021-04-27

  An anti-tumor traditional Chinese medicine, a preparation method therefor, and uses thereof. This traditional Chinese medicine is prepared by leavening of Pleurotus sp. and Dioscorea bulbifera, pangolin scales, rhubarb, oyster, stiff silkworm, kelp, selfheal, Ligusticum wallichii, barbat skullcap, honeysuckle flower, Oldenlandia diffusa, Radix trichosanthis, Rhizoma anemarrhenae Scutellaria baicalensis, Angelica sinensis, Psoralea corylifolia, Lucid ganoderma, and coix seed.

  一种抗肿瘤中药、其制备方法及其用途。这种中药是由浙贝母、穿山甲、大黄、牡蛎、僵蚕、海带等发酵而成。和薯蓣、穿山甲鳞片、大黄、牡蛎、僵蚕、海带、自愈菜、藁本、巴豆、金银花、老鹳草、三七、黄芩、当归、车前子、灵芝、薏苡仁发酵而成。
• EP1993580A1
  申请人：——

  公开号：EP1993580A1

  公开（公告）日：2008-11-26
• Combination Therapy for Treatment of Patients with Neurological Disorders and Cerebral Infarction
  申请人：Shi Xuemin

  公开号：US20090162459A1

  公开（公告）日：2009-06-25

  The present invention provides compositions and methods of treating a patient having a condition selected from the group of cerebral stroke, heart stroke, neurodegenerative diseases, brain or nervous system trauma, or neuroplasticity wherein the composition comprises: (i) at least 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 of: Radix Astragali (milkvetch root or Huang Qi); Rhizoma Salviae Miltiorrhizae root (red sage or Dan Shen); Radix Paeoniae Rubra (red peony or chi shao); Ligusticum Chuanxiong (Chuan Xiong); Rhizoma Notoginseng (Sanqi); Odoriferous Rosewood (Jiang Xiang); Scorpion (Quan Xie); Radix Polygalae (Yuan Zhi); Grassleaf sweetflag (Shi Changpu); Leech (Hirudo or Shuizhi); Ground beetle (Tu Bie Chong); Cow bezoar (calculus Bovis artifactus or Rengong Niuhuang); Gambirplant (ramulus uncariae cum uncis or Gou teng); and (ii) an agent used in Western medicine.
• NOVEL USE OF ORGANIC COMPOUNDS
  申请人：Fowler Ann

  公开号：US20090176873A1

  公开（公告）日：2009-07-09

  The present invention relates to the use of compounds of the formula (I) wherein the clotted line is an optional bond; R 1 is butyl or butyryl if R 2 is hydroxyl but is butyl if R 2 is hydrogen; or R 1 and R 2 taken together are 1-butylidene optionally substituted by hydroxyl, methyl, or 3-(α,β-dimethylacrylyloxy)-pentylidenyl; X is a residue selected from the group consisting of X1, X2, X3, X4, and X5; wherein X is X2, X3 or X5 if the dotted line in formula (I) is absent; and X is X1, X4 or X5 if the dotted line signifies a bond in formula (I) above; R 3 is hydroxyl or butyryl; and n is 1 or 2, as agents for the prevention, control and treatment of conditions requiring modulation of inflammation in mammals. In another aspect, the present invention relates to the use of compounds of the formula (I) as active ingredients in the manufacture of medicaments/compositions for the prevention, control and treatment of conditions requiring modulation of inflammation. The compounds of formula (I) as defined above may also be useful (for the manufacture of a composition) for the management of pain, fever and injuries, especially sport injuries. Moreover, the compounds of formula (I) as defined above may also be useful (for the manufacture of a composition) for the maintenance and regeneration of articular cartilage.