4-amino-N-(4-(cyanomethyl)phenyl)benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-amino-N-(4-(cyanomethyl)phenyl)benzenesulfonamide
• 英文别名: sulfanilic acid-(4-cyanomethyl-anilide)；(4-Sulfanilamino-phenyl)-acetonitril；Sulfanilsaeure-(4-cyanmethyl-anilid)；4-amino-N-[4-(cyanomethyl)phenyl]benzenesulfonamide
• 化学式: C₁₄H₁₃N₃O₂S
• 分子量: 287.342
• InChiKey: VAFQHVXEXVOFER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对氨基苯乙腈 在 吡啶 、 盐酸 作用下， 生成 4-amino-N-(4-(cyanomethyl)phenyl)benzenesulfonamide
  参考文献：
  名称：

  Midazolam premedication reduces propofol requirements for sedation during regional anesthesia

  摘要：

  Purpose: Propofol is often used for sedation during spinal anesthesia. We investigated the effects of midazolam premedication on the propofol requirements and incidence of complications during sedation.Methods: In a prospective randomized, controlled, and single-blinded study, 50 patients undergoing elective gynecological surgery were randomly divided into control and midazolam groups. Patients in the midazolam group received 2 mg midazolam im 30 min before arrival at the operation room. After spinal anesthesia was instituted with intrathecal injection of hyperbaric tetracaine, we provided sedation using continuous infusion of propofol, The level of sedation was controlled at a level between "eyes closed but reusable to command" and "eyes closed but reusable to mild physical stimulation" by adjusting the infusion rate. During sedation, the propofol requirements and complications were recorded and patients were asked, two hours after the end of operation, whether they remembered intraoperative events.Results: In the midazolam group, the loading dose, steady state infusion rate, and overall infusion rate of propofol were 0.74 mg.kg(-1), 2.86 mg.kg(-1).hr(-1), and 3.32 mg.kg(-1).hr(-1), respectively, which were about 17% lower than those in the control group (P < 0.05). Moreover, midazolam premedication reduced the incidence of intraoperative memory (P < 0.05), but had no effects on other complications.Conclusion: Midazolam premedication reduced propofol requirements and the incidence of intraoperative memory during sedation, These effects on sedation using propofol during spinal anesthesia are considered beneficial for patients.

  DOI：

  10.1007/bf03020731

文献信息

• Midazolam premedication reduces propofol requirements for sedation during regional anesthesia
  作者：Masashi Nakagawa、Tadanori Mammoto、Ayako Hazama、Takashi Kita、Tetsuya Akamatsu、Noriko Kambara、Toshiko Sakai、Yoshihiko Kishi

  DOI：10.1007/bf03020731

  日期：2000.1

  Purpose: Propofol is often used for sedation during spinal anesthesia. We investigated the effects of midazolam premedication on the propofol requirements and incidence of complications during sedation.Methods: In a prospective randomized, controlled, and single-blinded study, 50 patients undergoing elective gynecological surgery were randomly divided into control and midazolam groups. Patients in the midazolam group received 2 mg midazolam im 30 min before arrival at the operation room. After spinal anesthesia was instituted with intrathecal injection of hyperbaric tetracaine, we provided sedation using continuous infusion of propofol, The level of sedation was controlled at a level between "eyes closed but reusable to command" and "eyes closed but reusable to mild physical stimulation" by adjusting the infusion rate. During sedation, the propofol requirements and complications were recorded and patients were asked, two hours after the end of operation, whether they remembered intraoperative events.Results: In the midazolam group, the loading dose, steady state infusion rate, and overall infusion rate of propofol were 0.74 mg.kg(-1), 2.86 mg.kg(-1).hr(-1), and 3.32 mg.kg(-1).hr(-1), respectively, which were about 17% lower than those in the control group (P < 0.05). Moreover, midazolam premedication reduced the incidence of intraoperative memory (P < 0.05), but had no effects on other complications.Conclusion: Midazolam premedication reduced propofol requirements and the incidence of intraoperative memory during sedation, These effects on sedation using propofol during spinal anesthesia are considered beneficial for patients.