2-phenylchalcone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-phenylchalcone
• 英文别名: (E)-1-phenyl-3-(2-phenylphenyl)prop-2-en-1-one
• 化学式: C₂₁H₁₆O
• 分子量: 284.357
• InChiKey: QNCVIMGJHDEDAS-FOCLMDBBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• O-Phenyl Chalcone Compounds And Preparation Method And Use Thereof
  申请人：Sun Yat-Sen University

  公开号：US20160333033A1

  公开（公告）日：2016-11-17

  Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the aggregation of microtubules in tumor cells and influencing the mitosis of the cells, and have a high antitumor activity. The compounds also have inhibitory activity against proliferation on various tumor cells, such as a human ovary cancer cell A2780, a human colon cancer cell HCT8, a human breast cancer cell MCF7, a human lung cancer cell A549, a human colon cancer cell SW480, a human nasopharyngeal carcinoma cell CNE2, a human liver cancer cell HepG2 and the like at nanomole concentrations.

  揭示了一种 o-苯基查尔酮化合物及其制备方法和用途。这些 o-苯基查尔酮化合物能够抑制肿瘤细胞微管的聚集，影响细胞的有丝分裂，并具有较高的抗肿瘤活性。这些化合物还在纳摩尔浓度下对各种肿瘤细胞的增殖具有抑制活性，如人卵巢癌细胞A2780、人结肠癌细胞HCT8、人乳腺癌细胞MCF7、人肺癌细胞A549、人结肠癌细胞SW480、人鼻咽癌细胞CNE2、人肝癌细胞HepG2等。
• O-PHENYL CHALCONE COMPOUND AND PREPARATION METHOD AND USE THEREOF
  申请人：Sun Yat-Sen University

  公开号：EP3118204A1

  公开（公告）日：2017-01-18

  Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the aggregation of microtubules in tumor cells and influencing the mitosis of the cells, and has a high antitumor activity. The compounds also have inhibitory activity against proliferation on various tumor cells, such as a human ovary cancer cell A2780, a human colon cancer cell HCT8, a human breast cancer cell MCF7, a human lung cancer cell A549, a human colon cancer cell SW480, a human nasopharyngeal carcinoma cell CNE2, a human liver cancer cell HepG2 and the like at nanomole concentrations.

  本发明公开了一种邻苯基查尔酮化合物及其制备方法和用途。邻苯基查尔酮化合物能够抑制肿瘤细胞中微管的聚集，影响细胞的有丝分裂，具有很高的抗肿瘤活性。这些化合物还具有抑制各种肿瘤细胞增殖的活性，如纳摩尔浓度下的人卵巢癌细胞 A2780、人结肠癌细胞 HCT8、人乳腺癌细胞 MCF7、人肺癌细胞 A549、人结肠癌细胞 SW480、人鼻咽癌细胞 CNE2、人肝癌细胞 HepG2 等。
• [EN] O-PHENYL CHALCONE COMPOUND AND PREPARATION METHOD AND USE THEREOF<br/>[FR] COMPOSÉ O-PHÉNYLE CHALCONE ET SON PROCÉDÉ DE PRÉPARATION ET UTILISATION ASSOCIÉE<br/>[ZH] 邻苯基查尔酮类化合物及其制备方法和应用
  申请人：UNIV SUN YAT SEN

  公开号：WO2015109963A1

  公开（公告）日：2015-07-30

  本发明公开一种邻苯基查尔酮类化合物及其制备方法和应用。所述邻苯基查尔酮类化合物可以抑制肿瘤细胞内微管的聚集组装，影响细胞有丝分裂，具有强抗肿瘤活性，对多种肿瘤细胞，包括人卵巢癌细胞A2780，人结肠癌细胞HCT8，人乳腺癌细胞MCF7，人肺癌细胞A549，人结肠癌细胞SW480，人鼻咽癌细胞CNE2，人肝癌细胞HepG2等的增殖抑制的半数抑制浓度大部分达到纳摩尔每升的级别。此外，所述邻苯基查尔酮类化合物能有效对抗紫杉醇、长春碱、阿霉素、顺铂等临床药物耐受的多种多药耐药肿瘤，与现有临床代表性药物有阿霉素、紫杉醇、秋水仙碱及长春新碱等相比，本发明所述邻苯基查尔酮类化合物除了在抗耐药肿瘤方面具有显著优势，在物理化学性质上也具有结构新颖，合成简单，原料便宜、溶解性能好等重要优点。
• Novel benzopyrans and process for their production
  申请人：Council of Scientific and Industrial Research

  公开号：EP0470310B1

  公开（公告）日：1995-11-29
• O-PHENYL CHALCONE COMPOUNDS AND USES THEREOF
  申请人：Sun Yat-Sen University

  公开号：US20170247398A1

  公开（公告）日：2017-08-31

  Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the aggregation of microtubules in tumor cells and influencing the mitosis of the cells, and has a high antitumor activity. The compounds also have inhibitory activity against proliferation on various tumor cells, such as a human ovary cancer cell A2780, a human colon cancer cell HCT8, a human breast cancer cell MCF7, a human lung cancer cell A549, a human colon cancer cell SW480, a human nasopharyngeal carcinoma cell CNE2, a human liver cancer cell HepG2 and the like at nanomole concentrations.