4-((4-diphenylphosphinyl)benzylamino)-7-nitro-2,1,3-benzoxadiazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-((4-diphenylphosphinyl)benzylamino)-7-nitro-2,1,3-benzoxadiazole
• 英文别名: N-[(4-diphenylphosphorylphenyl)methyl]-4-nitro-2,1,3-benzoxadiazol-7-amine
• 化学式: C₂₅H₁₉N₄O₄P
• 分子量: 470.424
• InChiKey: SPCWAPFUKHRRDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-二苯基膦苯甲酸 在 lithium aluminium tetrahydride 、 六氯环三磷腈 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 乙腈 、 苯 为溶剂， 反应 3.34h， 生成 4-((4-diphenylphosphinyl)benzylamino)-7-nitro-2,1,3-benzoxadiazole
  参考文献：
  名称：

  First Fluorescent Photoinduced Electron Transfer (PET) Reagent for Hydroperoxides

  摘要：

  graphicA novel fluorescent reagent for hydroperoxides, 4-(2-diphenylphosphinoethylamino)-7-nitro-2,1,3-benzoxadiazole (1), was developed on the basis of the method for designing photoinduced electron transfer (PET) reagents having a benzofurazan skeleton. Compound 1 was quantitatively reacted with hydroperoxides to give its fluorescent derivative, 2. In acetonitrile, the Phi value (0.44) of 2 was 31 times greater than that of 1. The long excitation (458 nm) and emission (520 nm) wavelengths of 2 are suitable for the determination of hydroperoxides, especially in biosamples.

  DOI：

  10.1021/ol0342150

文献信息

• First Fluorescent Photoinduced Electron Transfer (PET) Reagent for Hydroperoxides
  作者：Maki Onoda、Seiichi Uchiyama、Atsushi Endo、Hidetoshi Tokuyama、Tomofumi Santa、Kazuhiro Imai

  DOI：10.1021/ol0342150

  日期：2003.5.1

  graphicA novel fluorescent reagent for hydroperoxides, 4-(2-diphenylphosphinoethylamino)-7-nitro-2,1,3-benzoxadiazole (1), was developed on the basis of the method for designing photoinduced electron transfer (PET) reagents having a benzofurazan skeleton. Compound 1 was quantitatively reacted with hydroperoxides to give its fluorescent derivative, 2. In acetonitrile, the Phi value (0.44) of 2 was 31 times greater than that of 1. The long excitation (458 nm) and emission (520 nm) wavelengths of 2 are suitable for the determination of hydroperoxides, especially in biosamples.