(E)-1-(4-tert-butylphenyl)-3-(2,4-dichlorophenyl)prop-2-en-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-1-(4-tert-butylphenyl)-3-(2,4-dichlorophenyl)prop-2-en-1-one
• 化学式: C₁₉H₁₈Cl₂O
• 分子量: 333.2
• InChiKey: FIPGJPBKBWODTF-YRNVUSSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] INHIBITORS OF IRES PORTION OF AN ENTEROVIRUS<br/>[FR] INHIBITEURS DE LA PARTIE IRES D'UN ENTÉROVIRUS
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2020022961A1

  公开（公告）日：2020-01-30

  The present invention relates to compositions for treating an enterovirus infection or an enterovirus induced disorder. In one aspect of the present invention, there is provided the use of a molecule such as flavonoid that inhibits or prevents an interaction between at least one IRES trans-acting factor (ITAF) and an IRES portion of an enterovirus for treating an enterovirus infection. In particular, a composition comprising prunin (ST077105) can suppress the human enterovirus 71 (HEVA71) in cell and murine models. Similar suppressive effect is also observed in cells infected with Hepatitis C virus and Coxsackie virus.