picolinic acid N¹-(2-pyridylmethylene)amidrazone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: picolinic acid N¹-(2-pyridylmethylene)amidrazone
• 英文别名: N'-(pyridin-2-ylmethylideneamino)pyridine-2-carboximidamide
• 化学式: C₁₂H₁₁N₅
• 分子量: 225.253
• InChiKey: RSFAFOBXOXFBID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ammonium hexafluorophosphate 、 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 picolinic acid N¹-(2-pyridylmethylene)amidrazone 以 甲醇 为溶剂， 反应 8.0h， 以79%的产率得到
  参考文献：
  名称：

  吡啶基嗪席夫碱配体对钌，铑和铱半三明治复合物表现出出乎意料的键合模式：合成和结构研究

  摘要：

  研究了多齿嗪席夫碱配体对对甲基钌，Cp * Rh和Cp * Ir配合物的反应。[（芳烃）MCl 2 ] 2（芳烃= 对-cymene，Cp *; M = Ru，Rh和Ir）与以1：2 M比率形成的嗪席夫碱配体（L1-L3）的反应导致形成[（arene）M（L）Cl] +类型的单核络合物的合成，而[Cp * MCl 2 ] 2（M = Rh / Ir）与嗪席夫碱配体（L1-L3）1：1的反应M比得到的双核铑和铱络合物轴承式[{的Cp *的MC1} 2（μ-L）] +（M ＝ Rh / Ir）。双核络合物中的配体对金属原子表现出有趣的配位模式。配体L3与[Cp * IrCl 2 ] 2二聚体的反应产生两个配位异构体，而与[Cp * RhCl 2 ] 2仅产生一种异构体。已经建立了铱配合物的两种异构体的分子结构。在铑和铱络合物中，配体L3充当单负五齿桥联配体，以一个三齿的方式配位一个金属中心，以

  DOI：

  10.1016/j.jorganchem.2017.03.005
• 作为产物：
  描述：

  吡啶-2-甲醛 、 2-吡啶氨基腙 以 乙醇 为溶剂， 以91%的产率得到picolinic acid N¹-(2-pyridylmethylene)amidrazone
  参考文献：
  名称：

  NewN1-Hetarylmethylene-Substituted Amidrazones with Potential Antimycobacterial Activity

  摘要：

  N-1-Hetarylmethylene (e.g. pyridyl, 2-benzoxazolyl, 2-benzofuryl) substituted picolinic acid amidrazones and pyrazine-2-carboxamidrazones were investigated. The compounds were accessible by reaction of the unsubstituted amidrazones with aldehydes. Pyrazine-2-carbox-N-1-(2-benzoxazolymethylene)amidrazones were obtained by a new multistep reaction. The investigated amidrazones were tested for their antibacterial activity against four strains of mycobacteria (M. tuberculosis, M. avium, M. intracellulare, M. lufu) and were shown to have rather low activity.

  DOI：

  10.1002/(sici)1521-4184(199912)332:12<427::aid-ardp427>3.0.co;2-h

文献信息

• NewN1-Hetarylmethylene-Substituted Amidrazones with Potential Antimycobacterial Activity
  作者：Donald Ranft、Torsten Seyfarth、Klaus-Jürgen Schaper、Gudrun Lehwark-Yvetot、Clemens Bruhn、Axel Büge

  DOI：10.1002/(sici)1521-4184(199912)332:12<427::aid-ardp427>3.0.co;2-h

  日期：1999.12

  N-1-Hetarylmethylene (e.g. pyridyl, 2-benzoxazolyl, 2-benzofuryl) substituted picolinic acid amidrazones and pyrazine-2-carboxamidrazones were investigated. The compounds were accessible by reaction of the unsubstituted amidrazones with aldehydes. Pyrazine-2-carbox-N-1-(2-benzoxazolymethylene)amidrazones were obtained by a new multistep reaction. The investigated amidrazones were tested for their antibacterial activity against four strains of mycobacteria (M. tuberculosis, M. avium, M. intracellulare, M. lufu) and were shown to have rather low activity.
• Pyridyl azine Schiff-base ligands exhibiting unexpected bonding modes towards ruthenium, rhodium and iridium half-sandwich complexes: Synthesis and structural studies
  作者：Sanjay Adhikari、Werner Kaminsky、Mohan Rao Kollipara

  DOI：10.1016/j.jorganchem.2017.03.005

  日期：2017.5

  the ligand L3 acted as uninegative pentadentate bridging ligand coordinating one metal center in a tridentate fashion and the other metal in a bidentate fashion. In the other isomer the ligand L3 behaved as uninegative tetradentate bridging ligand coordinating both iridium centers in a bidentate fashion. In the mononuclear complexes, the ligands are coordinated to the metal atom in a bidentate N∩N

  研究了多齿嗪席夫碱配体对对甲基钌，Cp * Rh和Cp * Ir配合物的反应。[（芳烃）MCl 2 ] 2（芳烃= 对-cymene，Cp *; M = Ru，Rh和Ir）与以1：2 M比率形成的嗪席夫碱配体（L1-L3）的反应导致形成[（arene）M（L）Cl] +类型的单核络合物的合成，而[Cp * MCl 2 ] 2（M = Rh / Ir）与嗪席夫碱配体（L1-L3）1：1的反应M比得到的双核铑和铱络合物轴承式[的Cp *的MC1} 2（μ-L）] +（M ＝ Rh / Ir）。双核络合物中的配体对金属原子表现出有趣的配位模式。配体L3与[Cp * IrCl 2 ] 2二聚体的反应产生两个配位异构体，而与[Cp * RhCl 2 ] 2仅产生一种异构体。已经建立了铱配合物的两种异构体的分子结构。在铑和铱络合物中，配体L3充当单负五齿桥联配体，以一个三齿的方式配位一个金属中心，以