(tert-butoxycarbonylamino)acetic acid 1-methylallyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (tert-butoxycarbonylamino)acetic acid 1-methylallyl ester
• 英文别名: But-3-en-2-yl 2-(tert-butoxycarbonylamino)acetate；but-3-en-2-yl 2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate
• 化学式: C₁₁H₁₉NO₄
• 分子量: 229.276
• InChiKey: CXLNNMYDGZPNLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (tert-butoxycarbonylamino)acetic acid 1-methylallyl ester 在 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以99%的产率得到rac-(E)-2-(tert-butoxycarbonylamino)hex-4-enoic acid
  参考文献：
  名称：

  7-脱氧cylindrospermopsin的推定结构的合成：抑制蛋白质合成不需要C7氧合。

  摘要：

  DOI：

  10.1002/anie.200500520
• 作为产物：
  描述：

  BOC-甘氨酸 、 3-丁烯-2-醇 在 4-二甲氨基吡啶 、 N,N'-二异丙基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以96%的产率得到(tert-butoxycarbonylamino)acetic acid 1-methylallyl ester
  参考文献：
  名称：

  Syntheses of the cylindrospermopsin alkaloids

  摘要：

  An intramolecular 1,3-dipolar cycloaddition has efficiently constructed the A-ring portions of the cylindrospermopsin alkaloids. A nitro-aldol addition of an elaborated nitroalkane to a pyrimidine aldehyde followed by an intramolecular reductive guanidinylation has enabled the syntheses of all three alkaloids in this family in 18-19 steps. We report the first asymmetric synthesis of cylindrospermopsin, unambiguously assigning its absolute configuration. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.02.044

文献信息

• FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE
  申请人：Zeng Qingping

  公开号：US20110263647A1

  公开（公告）日：2011-10-27

  The invention relates to thiazole compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

  本发明涉及一种式I的噻唑化合物及其组合物，其在治疗由蛋白激酶B（PKB）介导的疾病方面具有用途，其中变量具有本文所提供的定义。本发明还涉及在治疗与异常细胞生长、癌症、炎症和代谢紊乱有关的疾病状态中使用此类噻唑化合物和其组合物的治疗用途。
• Synthesis of the Putative Structure of 7-Deoxycylindrospermopsin: C7 Oxygenation Is Not Required for the Inhibition of Protein Synthesis
  作者：Ryan E. Looper、Maria T. C. Runnegar、Robert M. Williams

  DOI：10.1002/anie.200500520

  日期：2005.6.20
• Syntheses of the cylindrospermopsin alkaloids
  作者：Ryan E. Looper、Maria T.C. Runnegar、Robert M. Williams

  DOI：10.1016/j.tet.2006.02.044

  日期：2006.5

  An intramolecular 1,3-dipolar cycloaddition has efficiently constructed the A-ring portions of the cylindrospermopsin alkaloids. A nitro-aldol addition of an elaborated nitroalkane to a pyrimidine aldehyde followed by an intramolecular reductive guanidinylation has enabled the syntheses of all three alkaloids in this family in 18-19 steps. We report the first asymmetric synthesis of cylindrospermopsin, unambiguously assigning its absolute configuration. (c) 2006 Elsevier Ltd. All rights reserved.