2-[(3E)-4-phenyl-3-buten-1-yn-1-yl]-1H-indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-[(3E)-4-phenyl-3-buten-1-yn-1-yl]-1H-indole
• 英文别名: 2-[(E)-4-phenylbut-3-en-1-ynyl]-1H-indole
• 化学式: C₁₈H₁₃N
• 分子量: 243.308
• InChiKey: HXLDQAPGKBDLIG-ONNFQVAWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  [(Z)-2-溴乙烯基]苯 、 2-ethynyl-1H-indole 在 bis-triphenylphosphine-palladium(II) chloride copper(l) iodide 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以79%的产率得到2-[(3E)-4-phenyl-3-buten-1-yn-1-yl]-1H-indole
  参考文献：
  名称：

  A straightforward synthesis of indole and benzofuran derivatives

  摘要：

  A new methodology for the synthesis of indole and benzofuran derivatives has been devised. The starting materials, ortho-substituted aryl diynes, have been easily converted into new unsaturated bis-indolyl and bis-benzofuran derivatives and into 2-ethynylindole and 2-ethynylbenzofuran. Both these products have been further elaborated into more complex unsaturated indole-benzofuran and bis-benzofuran derivatives. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.10.100

文献信息

• A straightforward synthesis of indole and benzofuran derivatives
  作者：Vito Fiandanese、Daniela Bottalico、Giuseppe Marchese、Angela Punzi

  DOI：10.1016/j.tet.2007.10.100

  日期：2008.1

  A new methodology for the synthesis of indole and benzofuran derivatives has been devised. The starting materials, ortho-substituted aryl diynes, have been easily converted into new unsaturated bis-indolyl and bis-benzofuran derivatives and into 2-ethynylindole and 2-ethynylbenzofuran. Both these products have been further elaborated into more complex unsaturated indole-benzofuran and bis-benzofuran derivatives. (c) 2007 Elsevier Ltd. All rights reserved.