N-(6-methyl-2-hept-6-enylidene)-4-anisidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(6-methyl-2-hept-6-enylidene)-4-anisidine
• 英文别名: N-(4-methoxyphenyl)-6-methylhept-5-en-2-imine
• 化学式: C₁₅H₂₁NO
• 分子量: 231.338
• InChiKey: YXJILCFICIBYHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(6-methyl-2-hept-6-enylidene)-4-anisidine 在 四氢吡咯 、 rac-(ethylene-1,2-bis(4,5,6,7-tetrahydro-1-indenyl))TiF₂ polymethylhydrosiloxane 、 苯硅烷 、 异丁胺 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 13.0h， 生成 (4-methoxyphenyl)-(1,5-dimethyl-hex-4-enyl)amine 、 (+)-(4-methoxyphenyl)-(1,5-dimethyl-hex-4-enyl)amine
  参考文献：
  名称：

  A Method for the Asymmetric Hydrosilylation of N-Aryl Imines

  摘要：

  [GRAPHICS]The asymmetric reduction of N-aryl imines to yield chiral amines with enantiomeric excesses above 90% was achieved. Ethylenebis(eta(5)-tetrahydroindenyl)titanium difluoride ((EBTHI)TiF2, 1) was employed as the precatalyst with polymethylhydrosiloxane (PMHS) as the stoichiometric reducing agent. A variety of N-aryl imines derived from nonaromatic ketones were reduced with high ee.

  DOI：

  10.1021/ol005583w
• 作为产物：
  描述：

  6-甲基-5-庚烯-2-酮 、 3-甲基苯胺 以 甲苯 为溶剂， 以52%的产率得到N-(6-methyl-2-hept-6-enylidene)-4-anisidine
  参考文献：
  名称：

  A Method for the Asymmetric Hydrosilylation of N-Aryl Imines

  摘要：

  [GRAPHICS]The asymmetric reduction of N-aryl imines to yield chiral amines with enantiomeric excesses above 90% was achieved. Ethylenebis(eta(5)-tetrahydroindenyl)titanium difluoride ((EBTHI)TiF2, 1) was employed as the precatalyst with polymethylhydrosiloxane (PMHS) as the stoichiometric reducing agent. A variety of N-aryl imines derived from nonaromatic ketones were reduced with high ee.

  DOI：

  10.1021/ol005583w

文献信息

• A Method for the Asymmetric Hydrosilylation of <i>N</i>-Aryl Imines
  作者：Marcus C. Hansen、Stephen L. Buchwald

  DOI：10.1021/ol005583w

  日期：2000.3.1

  [GRAPHICS]The asymmetric reduction of N-aryl imines to yield chiral amines with enantiomeric excesses above 90% was achieved. Ethylenebis(eta(5)-tetrahydroindenyl)titanium difluoride ((EBTHI)TiF2, 1) was employed as the precatalyst with polymethylhydrosiloxane (PMHS) as the stoichiometric reducing agent. A variety of N-aryl imines derived from nonaromatic ketones were reduced with high ee.