4-ureidobutyric acid benzyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-ureidobutyric acid benzyl ester
• 英文别名: Benzyl 4-(carbamoylamino)butanoate
• 化学式: C₁₂H₁₆N₂O₃
• 分子量: 236.271
• InChiKey: ZDJDDENICJDOHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  苯甲醛 、 3-氧代-5-苯基-戊酸乙酯 、 4-ureidobutyric acid benzyl ester 在 盐酸 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  A solid phase protocol of the biginelli dihydropyrimidine synthesis suitable for combinatorial chemistry

  摘要：

  A new protocol for solid phase Biginelli condensations of beta-ketoesters, aldehydes and ureas has been developed. This method uses a Wang resin-linked GABA urea and provides dihydropyrimidines in a single operation in high yield and purity suitable for subsequent direct solution phase screening.

  DOI：

  10.1016/0040-4039(95)01660-a

文献信息

• CHROMATOGRAPHIC COLUMNS AND SEPARATION DEVICES COMPRISING A SUPERFICIALLY POROUS MATERIAL; AND USE THEREOF FOR SUPERCRITICAL FLUID CHROMATOGRAPHY AND OTHER CHROMATOGRAPHY
  申请人：Waters Technologies Corporation

  公开号：EP3936226A2

  公开（公告）日：2022-01-12

  The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are superficially porous chromatographic particulate materials comprising sized less than 2 microns.

  本发明提供了新型色谱材料，例如用于色谱分离的色谱材料、其制备工艺和含有该色谱材料的分离装置；包含该色谱材料的分离装置、色谱柱和试剂盒；以及其制备方法。本发明的色谱材料是表面多孔的色谱颗粒材料，其尺寸小于 2 微米。
• A solid phase protocol of the biginelli dihydropyrimidine synthesis suitable for combinatorial chemistry
  作者：Peter Wipf、April Cunningham

  DOI：10.1016/0040-4039(95)01660-a

  日期：1995.10

  A new protocol for solid phase Biginelli condensations of beta-ketoesters, aldehydes and ureas has been developed. This method uses a Wang resin-linked GABA urea and provides dihydropyrimidines in a single operation in high yield and purity suitable for subsequent direct solution phase screening.