N-(imidazo[2,1-b][1,3]thiazol-6-ylmethyl)-2,2-dimethylpropanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(imidazo[2,1-b][1,3]thiazol-6-ylmethyl)-2,2-dimethylpropanamide
• 化学式: C₁₁H₁₅N₃OS
• 分子量: 237.32
• InChiKey: DTBLNZQPWICYGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  74.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Substituted 6,5-Fused Bicyclic Heteroaryl Compounds
  申请人：Epizyme, Inc.

  公开号：US20140296283A1

  公开（公告）日：2014-10-02

  The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

  本发明涉及杂环双环杂芳基化合物。本发明还涉及含有这些化合物的药物组合物以及通过将这些化合物和药物组合物用于需要的受试者治疗癌症的方法。本发明还涉及将这些化合物用于研究或其他非治疗目的的使用。
• Substituted 6, 5-Fused Bicyclic Heteroaryl Compounds
  申请人：EPIZYME, INC.

  公开号：US20150246916A1

  公开（公告）日：2015-09-03

  The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

  本发明涉及杂环双环杂芳烃化合物。本发明还涉及含有这些化合物的药物组合物以及通过将这些化合物和药物组合物用于需要的受试者治疗癌症的方法。本发明还涉及将这些化合物用于研究或其他非治疗目的的用途。
• Substituted 6,5-fused bicyclic heteroaryl compounds
  申请人：Epizyme, Inc.

  公开号：US10174019B2

  公开（公告）日：2019-01-08

  The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

  本发明涉及唑类双环杂芳基化合物。本发明还涉及含有这些化合物的药物组合物，以及通过向有需要的受试者施用这些化合物和药物组合物来治疗癌症的方法。本发明还涉及将这些化合物用于研究或其它非治疗目的。
• Heterocycle-substituted bicyclic azole pesticides
  申请人：FMC CORPORATION

  公开号：US10822351B2

  公开（公告）日：2020-11-03

  Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein Q is and A, R1, m, X1, X2, X3, X4, Y1, Y2 and Y3 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

  公开的是式 1 的化合物，包括所有几何异构体和立体异构体、N-氧化物及其盐类、 其中 Q 是 和 A、R1、m、X1、X2、X3、X4、Y1、Y2 和 Y3 如公开内容中所定义。还公开了含有式 1 化合物的组合物和控制无脊椎害虫的方法，该方法包括将生物有效量的本发明化合物或组合物与无脊椎害虫或其环境接触。
• SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS
  申请人：Epizyme, Inc.

  公开号：US20160326170A1

  公开（公告）日：2016-11-10

  The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.