tetramethyl 3,3',3'',3'''-(hexane-1,6-diylbis(azanetriyl))tetrapropionate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tetramethyl 3,3',3'',3'''-(hexane-1,6-diylbis(azanetriyl))tetrapropionate
• 英文别名: tetramethyl 3,3',3'',3'''-(hexane-1,6-diylbis(azanetriyl))tetrapropanoate；Methyl 3-[6-[bis(3-methoxy-3-oxopropyl)amino]hexyl-(3-methoxy-3-oxopropyl)amino]propanoate；methyl 3-[6-[bis(3-methoxy-3-oxopropyl)amino]hexyl-(3-methoxy-3-oxopropyl)amino]propanoate
• 化学式: C₂₂H₄₀N₂O₈
• 分子量: 460.568
• InChiKey: SRBYYURULLSTLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  32
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  112
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  乙二胺 、 tetramethyl 3,3',3'',3'''-(hexane-1,6-diylbis(azanetriyl))tetrapropionate 以 甲醇 为溶剂， 反应 24.0h， 以67%的产率得到N-(2-aminoethyl)-3-[[3-(2-aminoethylamino)-3-oxopropyl]-[6-[bis[3-(2-aminoethylamino)-3-oxopropyl]amino]hexyl]amino]propanamide
  参考文献：
  名称：

  摘要：

  Neoglycoconjugates containing 4, 8, 32, and 64 terminal residues of B-disaccharide (B-DI) or N-acetylneuraminic acid (Neu5Ac) attached to poly(aminoamide)-type dendrimers (PAMAMs) were synthesized. The ability of B-DI conjugates to bind natural xenoantibodies (anti-B-DI, antibodies) and the ability of Neu5Ac conjugates to inhibit the hemagglutinin-mediated adhesion of influenza virus were studied. The biological activity of PAMAM conjugates turned out to be higher than that of free carbohydrate ligands, but less than that of multivalent glycoconjugates based on other types of synthetic polymeric carriers. A conformational analysis of PAMAM matrices and resulting conjugates was performed to determine the statistical distances between carbohydrate ligands. The computations revealed the tendency of the PAMAM chains toward compaction and formation of dense globules. The process results in a decrease in the distances between the carbohydrate ligands in the conjugates and, hence, could affect the ability of glycoconjugates to efficiently bind the polyvalent carbohydrate-recognizing proteins.

  DOI：

  10.1023/a:1021293532046
• 作为产物：
  描述：

  1,6-己二胺 、 丙烯酸甲酯（MA） 以 甲醇 为溶剂， 反应 10.17h， 以93.7%的产率得到tetramethyl 3,3',3'',3'''-(hexane-1,6-diylbis(azanetriyl))tetrapropionate
  参考文献：
  名称：

  一系列受阻哌啶衍生物的合成及光稳定能力

  摘要：

  摘要 以二胺、丙烯酸甲酯和2,2,6,6-五甲基-哌啶-4-醇为原料，通过迈克尔加成和酯交换反应，设计并合成了一系列含有四个受阻胺基团的新型受阻胺光稳定剂（HALS）。目标化合物的结构经1H NMR和13C NMR确证。选择其中两种用于评估其抗氧化和抗老化性能，并与聚丙烯 (PP) 和聚乙烯 (PE) 中的 HALS tinuvin 770、chimassorb 944、tinuvin 622、抗氧化剂 irganox B215 和 irganox B225 进行比较，并得出结果表明它们的抗氧化性和光稳定效率优于 HALS tinuvin 770、chimassorb 944、rinuvin 622 和抗氧化剂 irganox B215。图形概要

  DOI：

  10.1080/00397911.2010.540693

文献信息

• 一种含氟流变剂及其制备方法与应用
  申请人：中国石油天然气股份有限公司

  公开号：CN117003675A

  公开（公告）日：2023-11-07

  本发明提供了一种含氟流变剂及其制备方法与应用，具有如下式I结构，制备方法为将1.0G PAMAM树枝状大分子与全氟烷基磺酰氟进行反应，得到含氟流变剂。本发明含氟流变剂具有四个全氟己基磺酰氟基团，且分子量较大，在用于材料挤出成型过程中，不易发生迁移损失，可有效消除周期性熔体破裂，降低高粘度、高分子量树脂加工过程中的熔体温度，降低机头压力，减少螺杆扭矩，增加产量，提高挤出效率。#imgabs0#
• Synthesis and Light-Stabilizing Ability of a Series of Hindered Piperidine Derivatives
  作者：Wei Chen、Ping An、Yan-Xue Chen、Yang Li、Xi-Long Yan、Li-Gong Chen

  DOI：10.1080/00397911.2010.540693

  日期：2012.5.15

  Abstract A series of novel hindered amine light stabilizers (HALSs) containing four hindered amine groups were designed and synthesized from diamines, methyl acrylate, and 2,2,6,6-pentamethyl-piperidine-4-ol through Michael addition and transesterification. The structures of target compounds were confirmed by 1H NMR and 13C NMR. Two of them were chosen to be evaluated for their antioxidation and anti-aging

  摘要 以二胺、丙烯酸甲酯和2,2,6,6-五甲基-哌啶-4-醇为原料，通过迈克尔加成和酯交换反应，设计并合成了一系列含有四个受阻胺基团的新型受阻胺光稳定剂（HALS）。目标化合物的结构经1H NMR和13C NMR确证。选择其中两种用于评估其抗氧化和抗老化性能，并与聚丙烯 (PP) 和聚乙烯 (PE) 中的 HALS tinuvin 770、chimassorb 944、tinuvin 622、抗氧化剂 irganox B215 和 irganox B225 进行比较，并得出结果表明它们的抗氧化性和光稳定效率优于 HALS tinuvin 770、chimassorb 944、rinuvin 622 和抗氧化剂 irganox B215。图形概要
• ——
  作者：D. E. Tsvetkov、P. E. Cheshev、A. B. Tuzikov、A. A. Chinarev、G. V. Pazynina、M. A. Sablina、A. S. Gambaryan、N. V. Bovin、R. Rieben、A. S. Shashkov、N. E. Nifant'ev

  DOI：10.1023/a:1021293532046

  日期：——

  Neoglycoconjugates containing 4, 8, 32, and 64 terminal residues of B-disaccharide (B-DI) or N-acetylneuraminic acid (Neu5Ac) attached to poly(aminoamide)-type dendrimers (PAMAMs) were synthesized. The ability of B-DI conjugates to bind natural xenoantibodies (anti-B-DI, antibodies) and the ability of Neu5Ac conjugates to inhibit the hemagglutinin-mediated adhesion of influenza virus were studied. The biological activity of PAMAM conjugates turned out to be higher than that of free carbohydrate ligands, but less than that of multivalent glycoconjugates based on other types of synthetic polymeric carriers. A conformational analysis of PAMAM matrices and resulting conjugates was performed to determine the statistical distances between carbohydrate ligands. The computations revealed the tendency of the PAMAM chains toward compaction and formation of dense globules. The process results in a decrease in the distances between the carbohydrate ligands in the conjugates and, hence, could affect the ability of glycoconjugates to efficiently bind the polyvalent carbohydrate-recognizing proteins.