2-dodecanoylamino-succinic acid 4-methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-dodecanoylamino-succinic acid 4-methyl ester
• 英文别名: (2S)-2-(dodecanoylamino)-4-methoxy-4-oxobutanoic acid
• 化学式: C₁₇H₃₁NO₅
• 分子量: 329.437
• InChiKey: MICZVYPBUROXRF-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  23
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  92.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-dodecanoylamino-succinic acid 4-methyl ester 、 N-羟基丁二酰亚胺 在 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 2-dodecanoylamino-succinic acid 1-(2,5-dioxopyrrolidin-1-yl) ester 4-methyl ester
  参考文献：
  名称：

  Polymeric and dendrimeric pyridoxal enzyme mimics

  摘要：

  Pyridoxal was covalently attached to polyethylenimine polymers, but the resulting materials were found to degrade rapidly. In comparison, the dendrimeric pyridoxals, which possess only one pyridoxal unit at the core of every dendrimer molecule were found to be relatively stable compounds. A total of 12 poly(amidoamine) type dendrimers were synthesized. They range from G1 to G6 with either NMe2 or NHAc termini. The NMe2-terminated pyridoxal dendrimers racemize alpha-amino acids 50-100 times faster than does simple pyridoxal, while the NHAc-terminated pyridoxal dendrimers racemize alpha-amino acids only 3-5 times faster than does simple pyridoxal. Both the NMe2- and NHAc-terminated pyridoxal dendrimers decarboxylate 2-amino-2-phenyl-propionic acid 1-3 times faster than simple pyridoxal. The interior polarity in the pyridoxal dendrimers is similar to that of 85:15 water-DMFsolution. Furthermore we successfully incorporated eight lauryl groups to the G5 pyridoxal dendrimer at known positions. The laurylated dendrimer exhibits lower racemization and decarboxylation rates than do the unlaurylated ones, in contrast to the positive rate effects of laurylation in polyethylenimine-pyridoxamines in our previous transamination studies. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.03.062
• 作为产物：
  描述：

  1-(月桂酰氧基)-2,5-吡咯烷二酮 、 L-天冬氨酸-beta-甲酯盐酸盐 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 2-dodecanoylamino-succinic acid 4-methyl ester
  参考文献：
  名称：

  Polymeric and dendrimeric pyridoxal enzyme mimics

  摘要：

  Pyridoxal was covalently attached to polyethylenimine polymers, but the resulting materials were found to degrade rapidly. In comparison, the dendrimeric pyridoxals, which possess only one pyridoxal unit at the core of every dendrimer molecule were found to be relatively stable compounds. A total of 12 poly(amidoamine) type dendrimers were synthesized. They range from G1 to G6 with either NMe2 or NHAc termini. The NMe2-terminated pyridoxal dendrimers racemize alpha-amino acids 50-100 times faster than does simple pyridoxal, while the NHAc-terminated pyridoxal dendrimers racemize alpha-amino acids only 3-5 times faster than does simple pyridoxal. Both the NMe2- and NHAc-terminated pyridoxal dendrimers decarboxylate 2-amino-2-phenyl-propionic acid 1-3 times faster than simple pyridoxal. The interior polarity in the pyridoxal dendrimers is similar to that of 85:15 water-DMFsolution. Furthermore we successfully incorporated eight lauryl groups to the G5 pyridoxal dendrimer at known positions. The laurylated dendrimer exhibits lower racemization and decarboxylation rates than do the unlaurylated ones, in contrast to the positive rate effects of laurylation in polyethylenimine-pyridoxamines in our previous transamination studies. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.03.062

文献信息

• Cosmetics comprising an n-acylamino acid ester
  申请人：KASHIMA OIL COMPANY

  公开号：EP0839515A2

  公开（公告）日：1998-05-06

  There are disclosed cosmetics which comprise esters of N-acylamino acids containing acyl groups having odd-numbered carbon atoms, and esters of N-acylamino acids containing acyl groups having carbon atoms in an odd number in the range of 13 to 17. The above esters are used for the foregoing cosmetics, which have excellent hair growth promoting effect, humectant action, subcutaneous blood flow rate increasing action, etc. and thus are well suited for hair growth, skin care and the like.

  已公开的化妆品包括含有碳原子数为奇数的酰基的 N-酰基氨基酸的酯，以及含有碳原子数为 13 至 17 的奇数的酰基的 N-酰基氨基酸的酯。上述酯类用于上述化妆品，具有良好的促进头发生长效果、保湿作用、增加皮下血流量作用等，因此非常适合用于头发生长、皮肤护理等。
• BIODEGRADABLE CORROSION INHIBITORS
  申请人：THE ASSOCIATED OCTEL COMPANY LIMITED

  公开号：EP1080067A1

  公开（公告）日：2001-03-07
• US6010708A
  申请人：——

  公开号：US6010708A

  公开（公告）日：2000-01-04
• [EN] BIODEGRADABLE CORROSION INHIBITORS<br/>[FR] INHIBITEURS DE CORROSION BIODEGRADABLES
  申请人：THE ASSOCIATED OCTEL COMPANY LIMITED

  公开号：WO1999059958A1

  公开（公告）日：1999-11-25

  (EN) Compounds of formula (I), wherein R is the $g(a)-side chain of an amino acid, R1 is a straight or branched chain alkyl or alkenyl residue containing 1 to 30 carbon atoms or a cycloalkyl or aryl residue having from 5 to 12 carbon atoms; R2 is hydrogen or aryl or a straight chain alkyl or alkenyl residue having from 1 to 30 carbon atoms or together with R is the $g(a)-side chain of an amino acid; X is a linking moiety and Y is a suitable backbone moiety on which to append the N-acylated amino acid moieties via X linkages; and n is a number between 1 and the total number of available reactive substituents on Y; are corrosion inhibitors and/or scale inhibitors.(FR) L'invention porte sur des composés de formule (I) dans laquelle: R est la chaîne latérale $g(a) d'un acide aminé; R1 est un groupe alkyle ou alcényle C1-30 à chaîne droite ou ramifiée, ou un groupe cycloalkyle ou aryle C5-12; R2 est H ou aryle ou un groupe alkyle ou alcényle C1-30 à chaîne droite ou ramifiée ou forme avec R la chaîne latérale $g(a) d'un acide aminé; X est un fragment de liaison; Y est un fragment de squelette sur lequel peuvent se fixer les fragments d'acides aminés N-acétylés par l'intermédiaire de liaisons X; et n est un nombre compris entre 1 et le nombre total des substituants réactifs disponibles sur Y. Lesdits composés sont des inhibiteurs de corrosion et/ou des inhibiteurs scalaires.
• Polymeric and dendrimeric pyridoxal enzyme mimics
  作者：Lei Liu、Ronald Breslow

  DOI：10.1016/j.bmc.2004.03.062

  日期：2004.6

  Pyridoxal was covalently attached to polyethylenimine polymers, but the resulting materials were found to degrade rapidly. In comparison, the dendrimeric pyridoxals, which possess only one pyridoxal unit at the core of every dendrimer molecule were found to be relatively stable compounds. A total of 12 poly(amidoamine) type dendrimers were synthesized. They range from G1 to G6 with either NMe2 or NHAc termini. The NMe2-terminated pyridoxal dendrimers racemize alpha-amino acids 50-100 times faster than does simple pyridoxal, while the NHAc-terminated pyridoxal dendrimers racemize alpha-amino acids only 3-5 times faster than does simple pyridoxal. Both the NMe2- and NHAc-terminated pyridoxal dendrimers decarboxylate 2-amino-2-phenyl-propionic acid 1-3 times faster than simple pyridoxal. The interior polarity in the pyridoxal dendrimers is similar to that of 85:15 water-DMFsolution. Furthermore we successfully incorporated eight lauryl groups to the G5 pyridoxal dendrimer at known positions. The laurylated dendrimer exhibits lower racemization and decarboxylation rates than do the unlaurylated ones, in contrast to the positive rate effects of laurylation in polyethylenimine-pyridoxamines in our previous transamination studies. (C) 2004 Elsevier Ltd. All rights reserved.