2-(2-(2-hydroxyethoxy)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(2-(2-hydroxyethoxy)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione
• 英文别名: 2-[2-(2-Hydroxyethoxy)ethyl]-3a,4,7,7a-tetrahydro-4,7-epoxyisoindole-1,3-dione
• 化学式: C₁₂H₁₅NO₅
• 分子量: 253.255
• InChiKey: PKJUSJPBEHYVDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.07
• 重原子数：
  18.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  76.07
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-(2-(2-hydroxyethoxy)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione 、 甲基丙烯酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以79%的产率得到2-(2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-epoxyisoindol-2-yl)ethoxy)ethyl methacrylate
  参考文献：
  名称：

  Tuning the self-healing behavior of one-component intrinsic polymers

  摘要：

  Novel terpolymers with furan and maleimide units as functional moieties for the reversible crosslinking by the Diels-Alder (DA) reaction with different polar and nonpolar co-monomers and linkers have been prepared for potential applications as self-healing coatings. The synthesized linear one-component systems are able to crosslink via the functional units in the side chain (i.e. furan and maleimide) resulting in a highly crosslinked network. The terpolymers contain different maleimide methacrylates with three different linkers (MIMA 1, MIMA 2, MIMA 3), which vary in the length and the composition of the spacer unit as well as furfuryl methacrylate (FMA) as active units. Moreover, as polar co-monomers hydroxyethyl methacrylate (HEMA), dimethylaminoethyl methacrylate (DMAEMA) as well as 2-(hydroxyethoxy) ethyl methacrylate (DEGMA) and as nonpolar co-monomer butyl methacrylate (BMA) were used. The terpolymers were characterized using H-1 NMR spectroscopy and SEC measurements; the thermal properties were studied by TGA and DSC investigations as well as the self-healing properties by real-time analyses using a microscope equipped with a camera. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2015.03.027
• 作为产物：
  描述：

  4,10-二氧杂三环[5.2.1.0(2,6)]癸-8-烯-3,5-二酮 、 二甘醇胺 在 三乙胺 作用下， 以 甲醇 为溶剂， 反应 22.0h， 以38%的产率得到2-(2-(2-hydroxyethoxy)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione
  参考文献：
  名称：

  Tuning the self-healing behavior of one-component intrinsic polymers

  摘要：

  Novel terpolymers with furan and maleimide units as functional moieties for the reversible crosslinking by the Diels-Alder (DA) reaction with different polar and nonpolar co-monomers and linkers have been prepared for potential applications as self-healing coatings. The synthesized linear one-component systems are able to crosslink via the functional units in the side chain (i.e. furan and maleimide) resulting in a highly crosslinked network. The terpolymers contain different maleimide methacrylates with three different linkers (MIMA 1, MIMA 2, MIMA 3), which vary in the length and the composition of the spacer unit as well as furfuryl methacrylate (FMA) as active units. Moreover, as polar co-monomers hydroxyethyl methacrylate (HEMA), dimethylaminoethyl methacrylate (DMAEMA) as well as 2-(hydroxyethoxy) ethyl methacrylate (DEGMA) and as nonpolar co-monomer butyl methacrylate (BMA) were used. The terpolymers were characterized using H-1 NMR spectroscopy and SEC measurements; the thermal properties were studied by TGA and DSC investigations as well as the self-healing properties by real-time analyses using a microscope equipped with a camera. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2015.03.027

文献信息

• HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS
  申请人：Oligasis

  公开号：US20140024776A1

  公开（公告）日：2014-01-23

  The present invention provides multi-armed high MW polymers containing hydrophilic groups and one or more functional agents, and methods of preparing such polymers.

  本发明提供了含有亲水基团和一种或多种功能剂的多臂高分子量聚合物，以及制备这种聚合物的方法。
• MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES
  申请人：Charles Stephen A.

  公开号：US20130045522A1

  公开（公告）日：2013-02-21

  The present invention provides random copolymers containing zwitterions and one or more functional agents, and methods of preparing such random copolymers.

  本发明提供了含有双离子和一个或多个功能性试剂的随机共聚物，以及制备这种随机共聚物的方法。
• POLYMER COMPOSITIONS AND USES THEREOF
  申请人：Sleiman Hanadi

  公开号：US20090130665A1

  公开（公告）日：2009-05-21

  Block copolymers labelled with molecular recognition units and comprising a hydrophobic block and a luminescent block are presented. A method of detecting biomolecules using such block copolymers is also presented. More specifically, the block copolymers of the present invention have the following Formula (I): wherein “A” is a hydrophobic block; “B” is a luminescent block; “C” is a hydrophilic block; “D” is a molecular recognition unit; “n” and “m” are integers ranging from 1 to 75; “x” is either 0 or an integer ranging from 1 to 75; and “Y” is either 0 or 1.
• Shape-Memory-Self-Healing Polymers (SMSHPS)
  申请人：University of Florida Research Foundation, Inc.

  公开号：US20170008998A1

  公开（公告）日：2017-01-12

  A shape-memory self-healing polymeric network (SMSHP) is useful as a molded part, a coating, or as a matrix for a composite that can be repaired by heating to a controlled temperature. The SMSHP has thermally reversible repeating units where a thermally reversible adduct is situated between two common linking units formed during a polymerization process between thermally reversible monomers and cross-linking monomers. Optionally, other repeating units can be present from other monomers. Shape-memory results when the SMSHP is warmed to a temperature in excess of its glass transition temperature and self-healing then proceeds when a higher temperature is achieved where thermally reversible adducts dissociates to complementary groups that subsequently reform the adduct without distortion of the memorized shape. The thermally reversible adducts can be Diels-Alder (DA) adducts in a polyurethane, poly urea, or amine epoxy SMSHP network.
• US8324358B2
  申请人：——

  公开号：US8324358B2

  公开（公告）日：2012-12-04