5-(p-tolyloxy)pentan-1-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-(p-tolyloxy)pentan-1-amine
• 英文别名: 5-p-tolyloxy-pentylamine；(ε-Amino-n-amyl)-p-tolyl-aether；ε-p-Kresoxy-n-amylamin；5-(4-methylphenoxy)pentan-1-amine
• 化学式: C₁₂H₁₉NO
• 分子量: 193.289
• InChiKey: UZPSFQZSKKGCJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-(4'-methylphenoxy)pentanoic acid 在 lead(II) thiocyanate 作用下， 生成 5-(p-tolyloxy)pentan-1-amine
  参考文献：
  名称：

  Blank, Chemische Berichte, 1892, vol. 25, p. 3044

  摘要：

  DOI：

文献信息

• Beta-benzyloxyaspartate derivatives with amino group on benzene ring
  申请人：Shimamoto Keiko

  公开号：US20070238783A1

  公开（公告）日：2007-10-11

  L-threo-β-benzyloxyaspartate derivatives having a substituent on the benzene ring, represented by the following formula (1): wherein R is hydrogen, a linear or branched lower aliphatic acyl group with the acyl portion optionally substituted, an alicyclic acyl group, an aromatic acyl group with a substituent on the aromatic ring, an amino acid-derived group or a biotin derivative-derived group, having an amino substituent on the benzene ring, and salts thereof, which can easily bind to affinity column chromatography carriers as ligands of glutamate transporter proteins.

  具有苯环上取代基的L-单体-β-苄氧基天冬氨酸衍生物，化学式如下（1）：其中R为氢、具有酰基部分可选取代的线性或支链低级脂肪酰基、脂环酰基、苯环上具有取代基的芳香酰基、氨基酸衍生物基团或生物素衍生物基团，其在苯环上具有氨基取代基，以及其盐。该衍生物可以作为谷氨酸转运蛋白的配体，容易结合到亲和柱色谱载体上。
• N- versus O-Arylation of Aminoalcohols:  Orthogonal Selectivity in Copper-Based Catalysts
  作者：Alexandr Shafir、Phillip A. Lichtor、Stephen L. Buchwald

  DOI：10.1021/ja068926f

  日期：2007.3.1

  Two complementary protocols for copper-catalyzed arylation of aminoalcohols were developed. Selective N-arylation was accomplished at room temperature using 2-isobutyrylcyclohexanone (a beta-diketone) as supporting ligand, while selective O-arylation required the use of 3,4,7,8-tetramethylphenanthroline at 80-110 degrees C. Systematic examination of the reaction scope revealed that high levels of selectivity are achieved for a variety of substrates, provided that nonchelating (or weakly chelating) aminoalcohols are used. The generality of the method was highlighted by the synthesis, in a pairwise fashion, of a number of functionalized N- and O-arylated aminoalcohols.
• US7247652B2
  申请人：——

  公开号：US7247652B2

  公开（公告）日：2007-07-24
• US7666906B2
  申请人：——

  公开号：US7666906B2

  公开（公告）日：2010-02-23