5,5-dimethylhydantoinyl-3-ethyl dimethylamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5,5-dimethylhydantoinyl-3-ethyl dimethylamine
• 英文别名: 3-(2-(Dimethylamino)ethyl)-5,5-dimethylhydantoin；3-[2-(dimethylamino)ethyl]-5,5-dimethylimidazolidine-2,4-dione
• 化学式: C₉H₁₇N₃O₂
• 分子量: 199.253
• InChiKey: UXCRUKRDSHSVCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.12
• 重原子数：
  14.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  52.65
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  5,5-dimethylhydantoinyl-3-ethyl dimethylamine 在 盐酸 作用下， 以 丙酮 为溶剂， 生成 5,5-dimethylhydantoinyl-3-ethyl dimethylamine hydrochloride
  参考文献：
  名称：

  A high-efficacy and regenerable antimicrobial resin containing quaternarized N-halamine groups

  摘要：

  A novel macroporous cross-linked antimicrobial resin containing quaternarized N-halamine groups, poly(1-chloro-5,5-dimethylhydantoinyl-3-ethyl-p-ethenylphenylmethyl dimethylammonium chloride) (CI-PSQH), has been synthesized by a facile three-step reaction. The as-prepared resins were characterized by FT-IR, X-ray photoelectron spectroscopy, and zeta-potential measurement. Antimicrobial tests showed that CI-PSQH was capable of about a 7-log inactivation of Staphylococcus aureus and Escherichia coli O157:H7 within 1 min of contact. Also, its regenerability and preliminary storage stability were investigated. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.reactfunctpolym.2013.08.008
• 作为产物：
  描述：

  5,5-二甲基海因 、 二甲氨基氯乙烷盐酸 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 12.0h， 生成 5,5-dimethylhydantoinyl-3-ethyl dimethylamine
  参考文献：
  名称：

  A high-efficacy and regenerable antimicrobial resin containing quaternarized N-halamine groups

  摘要：

  A novel macroporous cross-linked antimicrobial resin containing quaternarized N-halamine groups, poly(1-chloro-5,5-dimethylhydantoinyl-3-ethyl-p-ethenylphenylmethyl dimethylammonium chloride) (CI-PSQH), has been synthesized by a facile three-step reaction. The as-prepared resins were characterized by FT-IR, X-ray photoelectron spectroscopy, and zeta-potential measurement. Antimicrobial tests showed that CI-PSQH was capable of about a 7-log inactivation of Staphylococcus aureus and Escherichia coli O157:H7 within 1 min of contact. Also, its regenerability and preliminary storage stability were investigated. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.reactfunctpolym.2013.08.008

文献信息

• Compounds, polymers and coating formulations that comprise at least one N-halamine precursor, a cationic center and a coating incorporation group
  申请人：UNIVERSITY OF MANITOBA

  公开号：US11059790B2

  公开（公告）日：2021-07-13

  The present disclosure relates to a compound that has biocidal activity or is a precursor of a compound with biocidal activity. The compound comprises an N-halamine precursor, at least one quaternary ammonium and at least one coating-incorporation group (CIG). In some embodiments of the present disclosure, the compound may be incorporated into a coating formulation. The coating formulation comprises the compound and at least one further component. In some embodiments of the present disclosure, the CIG reacts with the further component of the coating formulation to incorporate the compound into the coating formulation. In some embodiments, the coating formulation comprises a polymer. In some embodiments, the CIG of the compound reacts with the further component to incorporate the compound into the polymer of the coating formulation. The coating formulation may be used to coat a substrate. The coated substrate may demonstrate biocidal activity or the potential for increased biocidal activity.

  本公开涉及一种具有杀菌活性的化合物或具有杀菌活性化合物的前体。该化合物包括一种 N-卤胺前体、至少一种季铵和至少一种涂层结合基团（CIG）。在本公开的某些实施方案中，该化合物可掺入涂层配方中。涂层配方包括化合物和至少一种其它成分。在本公开的一些实施方案中，CIG 与涂层配方中的其他成分反应，将化合物掺入涂层配方中。在某些实施方案中，涂层配方包括聚合物。在某些实施例中，化合物的 CIG 与其他成分反应，将化合物掺入涂层配方的聚合物中。涂层配方可用于涂覆基质。涂层基质可显示杀菌活性或增加杀菌活性的潜力。
• BIOCIDAL COMPOUNDS AND METHODS FOR USING SAME
  申请人：UNIVERSITY OF MANITOBA

  公开号：US20150118179A1

  公开（公告）日：2015-04-30

  Biocidally active cationic analogs of N-halamine having two biocidally active groups covalently bonded together in a single molecule and having general Formula (I). Compounds of Formula (I), and precursors thereof, can be in solution form immobilized onto a substrate via physical coating or covalent chemical bonding to functionalize surfaces or added into materials as additives so as to render them biocidal. The biocidal solutions and substrates comprising the compounds or precursors of the present invention can then be used to inactivate pathogenic microorganisms. N-halamine-L-QUAT (I) wherein: the N-halamine may be a cyclic or acyclic N-halamine; L is C 1 -C 6 alkyl, cyclic aromatic or non-aromatic ring, ether, ketone or any other organic linking structures, and QUAT has general formula (II):
• A high-efficacy and regenerable antimicrobial resin containing quaternarized N-halamine groups
  作者：Zhiqiang Jie、Xiufang Yan、Lianhong Zhao、S.D. Worley、Jie Liang

  DOI：10.1016/j.reactfunctpolym.2013.08.008

  日期：2013.11

  A novel macroporous cross-linked antimicrobial resin containing quaternarized N-halamine groups, poly(1-chloro-5,5-dimethylhydantoinyl-3-ethyl-p-ethenylphenylmethyl dimethylammonium chloride) (CI-PSQH), has been synthesized by a facile three-step reaction. The as-prepared resins were characterized by FT-IR, X-ray photoelectron spectroscopy, and zeta-potential measurement. Antimicrobial tests showed that CI-PSQH was capable of about a 7-log inactivation of Staphylococcus aureus and Escherichia coli O157:H7 within 1 min of contact. Also, its regenerability and preliminary storage stability were investigated. (C) 2013 Elsevier Ltd. All rights reserved.