3-O-isopropyllamellarin U

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-O-isopropyllamellarin U
• 英文别名: 12-(3-Hydroxy-4-methoxyphenyl)-8,16,17-trimethoxy-7-propan-2-yloxy-4-oxa-1-azapentacyclo[11.8.0.02,11.05,10.014,19]henicosa-2(11),5,7,9,12,14,16,18-octaen-3-one
• 化学式: C₃₂H₃₁NO₈
• 分子量: 557.6
• InChiKey: NDJSBJYRVGHHFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  41
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  97.6
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  6,7-二甲氧基-3,4-二氢异喹啉 、 碘乙酸 、 5-碘-2-甲氧基苯酚 、 2-ethynyl-5-isopropoxy-4-methoxybenzaldehyde 以9%的产率得到3-O-isopropyllamellarin U
  参考文献：
  名称：

  Gaining diversity in solid-phase synthesis by modulation of cleavage conditions from hydroxymethyl-based supports. Application to lamellarin synthesis

  摘要：

  The application of a number of Lewis acids as a cleavage/deprotection method in the solid-phase synthesis of organic molecules can render several analogues, which, after purification, can be submitted for biological evaluation. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.05.119

文献信息

• Gaining diversity in solid-phase synthesis by modulation of cleavage conditions from hydroxymethyl-based supports. Application to lamellarin synthesis
  作者：Pablo Cironi、Carmen Cuevas、Fernando Albericio、Mercedes Álvarez

  DOI：10.1016/j.tet.2004.05.119

  日期：2004.9

  The application of a number of Lewis acids as a cleavage/deprotection method in the solid-phase synthesis of organic molecules can render several analogues, which, after purification, can be submitted for biological evaluation. (C) 2004 Elsevier Ltd. All rights reserved.