(E)-4-methoxy-N-(3-methyl-5-phenyl-1-p-tolylpent-3-enyl)benzenamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (E)-4-methoxy-N-(3-methyl-5-phenyl-1-p-tolylpent-3-enyl)benzenamine
• 英文别名: 4-methoxy-N-[(E)-3-methyl-1-(4-methylphenyl)-5-phenylpent-3-enyl]aniline
• 化学式: C₂₆H₂₉NO
• 分子量: 371.522
• InChiKey: FGBDUAOAQMXBRV-ZVBGSRNCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲氧苯胺 在 zinc(II) chloride 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 3.0h， 生成 (E)-4-methoxy-N-(3-methyl-5-phenyl-1-p-tolylpent-3-enyl)benzenamine
  参考文献：
  名称：

  Nickel-catalyzed four-component connection of oraganoaluminium (organozinc), isoprene, aldehydes and amines: stereo- and regioselective synthesis of trisubstituted (E)-homoallylamines

  摘要：

  Ni(acac)2催化三甲基铝（或二苯基锌）、异戊烯、芳香醛和对氨基茴香醚按此顺序的四组分连接反应，并选择性地以良好的产率提供（E）-1-芳基-1-(对甲氧基苯基)氨基-3-甲基-3-己烯（或（E）-1-芳基-1-(对甲氧基苯基)氨基-3-甲基-5-苯基-3-戊烯）。

  DOI：

  10.1039/b507229h

文献信息

• Nickel-catalyzed four-component connection of oraganoaluminium (organozinc), isoprene, aldehydes and amines: stereo- and regioselective synthesis of trisubstituted (E)-homoallylamines
  作者：Keisuke Kojima、Masanari Kimura、Yoshinao Tamaru

  DOI：10.1039/b507229h

  日期：——

  Ni(acac)2 catalyzes the four-component connection reaction of trimethylaluminium (or diphenylzinc), isoprene, aromatic aldehydes and p-anisidine in this order and provides (E)-1-aryl-1-(p-methoxyphenyl)amino-3-methyl-3-hexenes (or (E)-1-aryl-1-(p-methoxyphenyl)amino-3-methyl-5-phenyl-3-pentenes) selectively in good yield.

  Ni(acac)2催化三甲基铝（或二苯基锌）、异戊烯、芳香醛和对氨基茴香醚按此顺序的四组分连接反应，并选择性地以良好的产率提供（E）-1-芳基-1-(对甲氧基苯基)氨基-3-甲基-3-己烯（或（E）-1-芳基-1-(对甲氧基苯基)氨基-3-甲基-5-苯基-3-戊烯）。
• Nickel-catalyzed multi-component connection reaction of isoprene, aldimines (lactamines), and diphenylzinc
  作者：Keisuke Kojima、Masanari Kimura、Satoshi Ueda、Yoshinao Tamaru

  DOI：10.1016/j.tet.2006.03.116

  日期：2006.8

  Ni(acac)2 catalyzes the four-component connection reaction of diphenylzinc, isoprene, aromatic aldehydes, and aromatic amines in this order and provides stereochemically homogeneous (E)-1-arylamino-1-aryl-3-methyl-5-phenyl-3-pentenes (1) in excellent yields. Aliphatic aldehydes react similarly and give (E)-1-arylamino-1-alkyl-3-methyl-5-phenyl-3-pentenes (1) in slightly reduced yields. When the alkyl groups are bulky, in addition to I are formed (E)-1-arylamino-1-alkyl-4-methyl-5-phenyl-3-pentenes (F) as the minor products. Lactamines prepared in situ from five- and six-membered lactols and aromatic amines are more reactive than alkyl aldehyde aldimines and furnish (E)-4-arylamino-6-methyl-8-phenyl-6-octen-1-ols (4) and (E)-5-arylamino-7-methyl-9-phenyl-7-nonen-1-ols (5), respectively, in good yields with excellent E-stereoselectivity. (c) 2006 Elsevier Ltd. All rights reserved.