2-Cyclopropyl-4-isopropylthiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Cyclopropyl-4-isopropylthiazole
• 英文别名: 2-cyclopropyl-4-propan-2-yl-1,3-thiazole
• 化学式: C₉H₁₃NS
• 分子量: 167.27
• InChiKey: IMFDQEHZNBXZDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• BENZIMIDAZOLE COMPOUNDS AND USE THEREOF FOR TREATING ALZHEIMER'S DISEASE OR HUNTINGTON'S DISEASE
  申请人：National Health Research Institutes

  公开号：US20200071312A1

  公开（公告）日：2020-03-05

  Benzimidazole compounds of formula (I), shown below, are disclosed. The compounds are potent human glutaminyl cyclase inhibitors. Also disclosed is a pharmaceutical composition containing one of these compounds and a pharmaceutical acceptable carrier, as well as a method of treating Alzheimer's disease or Huntington's disease by administering to a subject in need thereof an effective amount of such a compound.

  以下显示的化学式（I）的苯并咪唑化合物已被披露。这些化合物是强效的人类谷氨酰环化酶抑制剂。还披露了一种含有其中一种这些化合物和一种药用可接受载体的药物组合物，以及通过向需要的受试者施用这种化合物的有效量来治疗阿尔茨海默病或亨廷顿病的方法。
• [EN] HETEROCYCLIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEURS UTILISATIONS
  申请人：NUVATION BIO INC

  公开号：WO2020210375A1

  公开（公告）日：2020-10-15

  Heterocyclic compounds as Weel inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

  提供了作为Weel抑制剂的杂环化合物。这些化合物可能作为治疗药物用于治疗疾病，并且在肿瘤学中可能发挥特定作用。
• INHIBITORS OF BRUTON'S TYROSINE KINASE
  申请人：Chen Wei

  公开号：US20160031891A1

  公开（公告）日：2016-02-04

  Disclosed herein are amido compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

  本文公开了一种与布鲁顿酪氨酸激酶（Btk）形成共价键的酰胺化合物。还描述了Btk的不可逆抑制剂。还公开了包括这些化合物的药物组合物。公开了使用Btk抑制剂的方法，单独或与其他治疗剂一起用于治疗自身免疫性疾病或病况，异体免疫性疾病或病况，癌症，包括淋巴瘤和炎症性疾病或病况。
• US9533991B2
  申请人：——

  公开号：US9533991B2

  公开（公告）日：2017-01-03