cis-4,4-dimethyloctahydrocyclopenta[b][1,4]diazepin-2-one

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cis-4,4-dimethyloctahydrocyclopenta[b][1,4]diazepin-2-one
• 英文别名: cis-4,4-Dimethyloctahydrocyclopenta[b][1,4]diazepin-2-one；(5aR,8aS)-4,4-dimethyl-1,3,5,5a,6,7,8,8a-octahydrocyclopenta[b][1,4]diazepin-2-one
• 化学式: C₁₀H₁₈N₂O
• 分子量: 182.266
• InChiKey: SQUQFPJDYSRULJ-JGVFFNPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,3-二甲基丙烯酸 、 顺式-1,2-环戊烷二胺 在 乙醚 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以to obtain cis-4,4-dimethyloctahydrocyclopenta[b][1,4]diazepin-2-one (8.60 g, 24%) in a light brown powder form的产率得到cis-4,4-dimethyloctahydrocyclopenta[b][1,4]diazepin-2-one
  参考文献：
  名称：

  Substituted quinoxalines compounds

  摘要：

  一种由通式（1）或其盐表示的杂环化合物： 其中，m、l和n分别表示1或2的整数；X表示—O—或—CH2—；R1表示氢、低碳基、羟基-低碳基、保护基或三-低碳基硅氧-低碳基；R2和R3分别独立地表示氢或低碳基；或R2和R3结合形成环状C3-C8烷基；且R4表示芳香基或杂环基，其中芳香或杂环基可以具有一个或多个任意的取代基。

  公开号：

  US09090572B2

文献信息

• [EN] DECAHYDROQUINOXALINE DERIVATIVES AND ANALOGS THEREOF<br/>[FR] DÉRIVÉS DE DÉCAHYDROQUINOXALINE ET LEURS ANALOGUES
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2013137479A1

  公开（公告）日：2013-09-19

  A heterocyclic compound represented by the general formula (1) or a salt thereof: wherein m, l, and n respectively represent an integer of 1 or 2; X represents -O- or -CH2-; R1 represents hydrogen, a lower alkyl group, a hydroxy-lower alkyl group, a protecting group, or a tri-lower alkylsilyloxy-lower alkyl group; R2 and R3, which are the same or different, each independently represent hydrogen or a lower alkyl group; or R2 and R3 are bonded to form a cyclo-C3-C8 alkyl group; and R4 represents an aromatic group or a heterocyclic group, wherein the aromatic or heterocyclic group may have one or more arbitrary substituent(s).

  通用式（1）表示的杂环化合物或其盐：其中m，l和n分别表示1或2的整数；X表示-O-或-CH2-；R1表示氢，较低的烷基基团，羟基较低的烷基基团，保护基或三较低烷氧基较低的烷基基团；R2和R3，相同或不同，各自独立地表示氢或较低的烷基基团；或R2和R3结合形成环-C3-C8烷基基团；R4表示芳香基团或杂环基团，其中芳香基团或杂环基团可能具有一个或多个任意取代基。
• HETEROCYCLIC COMPOUNDS FOR TREATING OR PREVENTING DISORDERS CAUSED BY REDUCED NEUROTRANSMISSION OF SEROTONIN, NOREPHNEPHRINE OR DOPAMINE
  申请人：Ito Nobuaki

  公开号：US20130261081A1

  公开（公告）日：2013-10-03

  A heterocyclic compound represented by the general formula (1) or a salt thereof: wherein m, l, and n respectively represent an integer of 1 or 2; X represents —O— or —CH 2 —; R 1 represents hydrogen, a lower alkyl group, a hydroxy-lower alkyl group, a protecting group, or a tri-lower alkylsilyloxy-lower alkyl group; R 2 and R 3 , which are the same or different, each independently represent hydrogen or a lower alkyl group; or R 2 and R 3 are bonded to form a cyclo-C3-C8 alkyl group; and R 4 represents an aromatic group or a heterocyclic group, wherein the aromatic or heterocyclic group may have one or more arbitrary substituent(s).

  一种由通式（1）表示的杂环化合物或其盐： 其中，m、l和n分别表示1或2的整数；X表示-O-或-CH2-；R1表示氢、低碳基、羟基-低碳基、保护基或三-低硅氧基-低碳基；R2和R3分别独立地表示氢或低碳基；或者R2和R3结合形成环状C3-C8烷基；R4表示芳基或杂环基，其中芳基或杂环基可能具有一个或多个任意取代基。
• Substituted quinoxalines compounds
  申请人：Ito Nobuaki

  公开号：US09090572B2

  公开（公告）日：2015-07-28

  A heterocyclic compound represented by the general formula (1) or a salt thereof: wherein m, l, and n respectively represent an integer of 1 or 2; X represents —O— or —CH2—; R1 represents hydrogen, a lower alkyl group, a hydroxy-lower alkyl group, a protecting group, or a tri-lower alkylsilyloxy-lower alkyl group; R2 and R3, which are the same or different, each independently represent hydrogen or a lower alkyl group; or R2 and R3 are bonded to form a cyclo-C3-C8 alkyl group; and R4 represents an aromatic group or a heterocyclic group, wherein the aromatic or heterocyclic group may have one or more arbitrary substituent(s).

  一种由通式（1）或其盐表示的杂环化合物： 其中，m、l和n分别表示1或2的整数；X表示—O—或—CH2—；R1表示氢、低碳基、羟基-低碳基、保护基或三-低碳基硅氧-低碳基；R2和R3分别独立地表示氢或低碳基；或R2和R3结合形成环状C3-C8烷基；且R4表示芳香基或杂环基，其中芳香或杂环基可以具有一个或多个任意的取代基。
• HETEROCYCLIC COMPOUNDS FOR TREATING OR PREVENTING DISORERS CAUSED BY REDUCED NEUROTRANSMISSION OF SEROTONIN, NOREPHNEPHRINE OR DOPAMINE
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：US20160058757A1

  公开（公告）日：2016-03-03

  A heterocyclic compound represented by the general formula (1) or a salt thereof: wherein m, I, and n respectively represent an integer of 1 or 2; X represents —O— or —CH 2 —; R 1 represents hydrogen, a lower alkyl group, a hydroxy-lower alkyl group, a protecting group, or a tri-lower alkylsilyloxy-lower alkyl group; R 2 and R 3 , which are the same or different, each independently represent hydrogen or a lower alkyl group; or R 2 and R 3 are bonded to form a cyclo-C3-C8 alkyl group; and R 4 represents an aromatic group or a heterocyclic group, wherein the aromatic or heterocyclic group may have one or more arbitrary substituent(s).

  一种由通式（1）表示的杂环化合物或其盐： 其中，m、I和n分别表示1或2的整数；X表示—O—或—CH2—；R1表示氢、低级烷基、羟基-低级烷基、保护基或三-低级烷基硅氧-低级烷基；R2和R3分别独立地表示氢或低级烷基；或R2和R3结合形成环状C3-C8烷基；且R4表示芳香基或杂环基，其中芳香或杂环基可以具有一个或多个任意取代基。