N-methyl-1,3-diphenylpyrazole-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-methyl-1,3-diphenylpyrazole-4-carboxamide
• 化学式: C₁₇H₁₅N₃O
• 分子量: 277.32
• InChiKey: QKXXEBKWGGBSCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] NEUROKININ-3 RECEPTOR MODULATORS: DIARYL PYRAZOLE DERIVATIVES<br/>[FR] MODULATEURS DE RECEPTEURS NEUROKININE 3 : DERIVES PYRAZOLES DE DIARYLE
  申请人：NEUROGEN CORP

  公开号：WO2005061462A2

  公开（公告）日：2005-07-07

  The invention relates to compounds of general Formula (I) wherein the variables are as defined herein. Pharmaceutical compositions comprising compounds of general Formula (I), and methods for treating patients suffering from a disorder responsive to neurokinin-3 receptor modulation are also provided. Compounds provided herein are also useful as probes for the localization of NK-3 receptors.