N-cinnamyl-4-methoxy-2-methylaniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-cinnamyl-4-methoxy-2-methylaniline
• 英文别名: 4-methoxy-2-methyl-N-[(E)-3-phenylprop-2-enyl]aniline
• 化学式: C₁₇H₁₉NO
• 分子量: 253.344
• InChiKey: FMPQQCKAKRZLKJ-RMKNXTFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-苯基丙-2-烯-1-醇 、 2-甲基-4-甲氧基苯胺 在 bis(acetylacetonato)palladium(II) 1-金刚烷甲酸 、 三苯基膦 作用下， 以 水 为溶剂， 反应 0.5h， 以59%的产率得到N-cinnamyl-4-methoxy-2-methylaniline
  参考文献：
  名称：

  Direct palladium/carboxylic acid-catalyzed allylation of anilines with allylic alcohols in water

  摘要：

  The direct activation of C-O bonds in allylic alcohols in water as a suspension medium by palladium complexes has been accelerated by carrying out the reactions in the presence of a carboxylic acid. The palladium-catalyzed allylation of anilines using allylic alcohols directly gave allylic anilines in good yields. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.02.035

文献信息

• Direct palladium/carboxylic acid-catalyzed allylation of anilines with allylic alcohols in water
  作者：Shyh-Chyun Yang、Yi-Chun Hsu、Kim-Hong Gan

  DOI：10.1016/j.tet.2006.02.035

  日期：2006.4

  The direct activation of C-O bonds in allylic alcohols in water as a suspension medium by palladium complexes has been accelerated by carrying out the reactions in the presence of a carboxylic acid. The palladium-catalyzed allylation of anilines using allylic alcohols directly gave allylic anilines in good yields. (c) 2006 Elsevier Ltd. All rights reserved.