methyl 1-[(tert-butoxycarbonyl)amino]-2-methyl-4,5-diphenyl-1H-pyrrole-3-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: methyl 1-[(tert-butoxycarbonyl)amino]-2-methyl-4,5-diphenyl-1H-pyrrole-3-carboxylate
• 英文别名: Methyl 2-methyl-1-[(2-methylpropan-2-yl)oxycarbonylamino]-4,5-diphenylpyrrole-3-carboxylate
• 化学式: C₂₄H₂₆N₂O₄
• 分子量: 406.481
• InChiKey: SODWYZBNJCGRSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  69.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  联苯乙醛 在 sodium methylate 、 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 methyl 1-[(tert-butoxycarbonyl)amino]-2-methyl-4,5-diphenyl-1H-pyrrole-3-carboxylate
  参考文献：
  名称：

  Straightforward Entry into 5-Hydroxy-1-aminopyrrolines and the Corresponding Pyrroles from 1,2-Diaza-1,3-butadienes

  摘要：

  The synthesis of 5-hydroxy-1-aminopyrroline-3-carboxylic acid derivatives and 5-unsubstituted-1-aminopyrrole-3-carboxylic acid derivatives from 1,2-diaza-1,3-butadienes and aldehydes is presented. These domino reactions offer the advantage of executing multistep transformation without intermediate workup procedures. The stereoselectivity of ring closure to 5-hydroxy-1-aminopyrroline-3-carboxylic acid derivatives and phenyl transposition to 2,3-diphenyl-1-aminopyrrole-3-carboxylic acid derivatives are also studied.

  DOI：

  10.1021/jo025656k

文献信息

• Straightforward Entry into 5-Hydroxy-1-aminopyrrolines and the Corresponding Pyrroles from 1,2-Diaza-1,3-butadienes
  作者：Orazio A. Attanasi、Lucia De Crescentini、Gianfranco Favi、Paolino Filippone、Fabio Mantellini、Stefania Santeusanio

  DOI：10.1021/jo025656k

  日期：2002.11.1

  The synthesis of 5-hydroxy-1-aminopyrroline-3-carboxylic acid derivatives and 5-unsubstituted-1-aminopyrrole-3-carboxylic acid derivatives from 1,2-diaza-1,3-butadienes and aldehydes is presented. These domino reactions offer the advantage of executing multistep transformation without intermediate workup procedures. The stereoselectivity of ring closure to 5-hydroxy-1-aminopyrroline-3-carboxylic acid derivatives and phenyl transposition to 2,3-diphenyl-1-aminopyrrole-3-carboxylic acid derivatives are also studied.