ethyl 1,6-dihydro-3-hydroxy-5-methyl-6-oxo-1-phenylpyrano<2,3-c>pyrazole-4-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 1,6-dihydro-3-hydroxy-5-methyl-6-oxo-1-phenylpyrano<2,3-c>pyrazole-4-carboxylate
• 英文别名: ethyl 5-methyl-3,6-dioxo-1-phenyl-2H-pyrano[2,3-c]pyrazole-4-carboxylate
• 化学式: C₁₆H₁₄N₂O₅
• 分子量: 314.298
• InChiKey: IWVIUWNHXQDGCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  84.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  草酰丙酸二乙酯 、 1-苯基吡唑烷-3,5-二酮 反应 2.0h， 以80%的产率得到ethyl 1,6-dihydro-3-hydroxy-5-methyl-6-oxo-1-phenylpyrano<2,3-c>pyrazole-4-carboxylate
  参考文献：
  名称：

  Eynde, Jean-Jacques Vanden; Haverbeke, Yves Van, Bulletin des Societes Chimiques Belges, 1993, vol. 102, # 4, p. 295 - 296

  摘要：

  DOI：

文献信息

• TREATMENT OF ABNORMALITIES OF GLUCOSE METABOLISM WITH AN ANTAGONIST OF INHIBITOR OF DIFFERENTIATION 1
  申请人：Akerfeldt Mia

  公开号：US20130171158A1

  公开（公告）日：2013-07-04

  A method of treating or preventing an abnormality of glucose metabolism in a subject, the method comprising administering an antagonist of Inhibitor of Differentiation 1 (Id1) to the subject.

  一种治疗或预防主体的葡萄糖代谢异常的方法，该方法包括向主体给予抑制分化因子1（Id1）的拮抗剂。
• Chemical Inhibitors of Inhibitors of Differentiation
  申请人：CHAUDHARY Jaideep

  公开号：US20090226422A1

  公开（公告）日：2009-09-10

  The present invention provides identification of inhibitors of inhibitors of differentiation (Id) for use in the treatment and prevention of diseases in mammals. The inhibitors of Id are effective alone in the treatment of a variety of cellular proliferative disorders including, but not limited to, diseases such as cancer, arthritis, age-related macular degeneration, psoriasis, neoplasms, angiomas, endometriosis, obesity, age-related macular degeneration, retinopathies, restenosis, scaring, fibrogenesis, fibrosis, cardiac remodeling, pulmonary fibrosis, scleroderma, failure associated with myocardial infarction, keloids, fibroid tumors and stenting. Additionally, these compounds are effective in blocking angiogenesis in tumor development, inducing apoptosis in malignant cells, inhibiting proliferation of cancer cells, increasing the effectiveness of chemotherapeutic agents, regulating transcriptional activity, reducing inflammation, increasing cellular differentiation, modulating ETS domain transcription factors, modulating PAX transcription factors, modulating TCF-ETS domain transcription factors, down regulating RAF-1/MAPK, upregulating JNK signaling pathways, and modulating cellular transformation.
• US8138356B2
  申请人：——

  公开号：US8138356B2

  公开（公告）日：2012-03-20
• [EN] TREATMENT OF ABNORMALITIES OF GLUCOSE METABOLISM WITH AN ANTAGONIST OF INHIBITOR OF DIFFERENTIATION 1<br/>[FR] TRAITEMENT D'ANOMALIES DU MÉTABOLISME DU GLUCOSE AVEC UN ANTAGONISTE D'INHIBITEUR DE LA DIFFÉRENCIATION 1
  申请人：GARVAN INST MED RES

  公开号：WO2012000036A1

  公开（公告）日：2012-01-05

  A method of treating or preventing an abnormality of glucose metabolism in a subject, the method comprising administering an antagonist of Inhibitor of Differentiation 1 (Id1) to the subject.