3-methyl Valpromide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-methyl Valpromide
• 英文别名: 3-methyl-2-propylpentanamide；sec-butyl-propylacetamide；sec-butylpropylacetamide；SPD；3-methyl-2-propyl-valeric acid amide；3-Methyl-2-propyl-valeriansaeure-amid
• 化学式: C₉H₁₉NO
• 分子量: 157.256
• InChiKey: ICMNKCCFRUPZCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-methyl-2-propyl-valeryl chloride 在 ammonium hydroxide 作用下， 以 水 、 乙腈 为溶剂， 反应 2.0h， 生成 3-methyl Valpromide
  参考文献：
  名称：

  丙戊酸类似物的新型酰胺和尿素衍生物的合成及抗痛觉过敏和抗惊厥活性的评价

  摘要：

  丙戊酸（VPA，1）是主要的广谱抗癫痫药和中枢神经系统药物，广泛用于治疗癫痫，双相情感障碍和偏头痛。VPA的临床使用受到两种严重且危及生命的副作用，致畸性和肝毒性的限制。合成了许多VPA类似物及其酰胺，N-甲基酰胺和尿素衍生物，并在神经性疼痛和癫痫的动物模型中进行了评估。其中，两种酰胺和两种尿素衍生物（1）作为抗神经痛药的效价最高，酰胺（19和20）的ED 50值分别为49和51 mg / kg，尿素衍生物的ED 50值为49和74 mg / kg。 （29和33）。19，20，和29是等效于加巴喷丁，用于治疗神经性疼痛的主要药物。这些数据表明上述新型化合物作为用于治疗神经性疼痛的未来药物开发的候选物的巨大潜力。

  DOI：

  10.1021/jm901229s

文献信息

• Influence of structure and chemistry on piezoelectric properties of lead zirconate titanate in a microelectromechanical systems power generation application
  作者：L. M. R. Eakins、B. W. Olson、C. D. Richards、R. F. Richards、D. F. Bahr

  DOI：10.1557/jmr.2003.0292

  日期：2003.9

  Lead zirconate titanate (PZT) films between 1 and 3 μm thick were grown using solution deposition techniques to study the effects of crystal structure and orientation on the direct piezoelectric output of these films on platinized Si membranes. By varying the chemistry of the film from Zr-rich to Ti-rich, the 100}/(111) relative intensity increased for films grown on randomly oriented Pt films. The 40:60 PZT had a tetragonal crystal structure and produced greater electrical output at a given strain than the rhombohedral film (Zr:Ti concentrations less than 50:50), while having a similar e₃₁ constant, between 4.8 and 6.3 C/m². Orientation and voltage output at a given strain were not strongly influenced by thickness in the ranges investigated. Defects in internal PZT/PZT crystallization interfaces were identified and include porosity on the order of tens of nm, with a corresponding depletion in Pb and accumulation of O at these interfaces. The 100} texture of rhombohedral films deposited upon (111) textured Pt films is significantly greater than the 100} texture of tetragonal films, which show both a 100} and 111} orientation on the same Pt film.

  利用溶液沉积技术生长了厚度为 1 至 3 μm 的锆钛酸铅（PZT）薄膜，以研究晶体结构和取向对这些薄膜在铂化硅膜上的直接压电输出的影响。通过改变薄膜的化学性质（从富含 Zr 到富含 Ti），在随机取向的铂薄膜上生长的薄膜的 100}/(111) 相对强度增加了。40:60 PZT 具有四方晶体结构，在给定应变下比斜方体薄膜（Zr:Ti 浓度低于 50:50）产生更大的电输出，同时具有相似的 e31 常量，介于 4.8 和 6.3 C/m2 之间。在所研究的范围内，厚度对给定应变下的方向和电压输出影响不大。在 PZT/PZT 内部结晶界面上发现了缺陷，包括数十纳米量级的孔隙率，以及在这些界面上相应的铅耗竭和 O 积累。沉积在(111)纹理铂薄膜上的斜方体薄膜的100}纹理明显大于四方薄膜的100}纹理，后者在同一铂薄膜上同时显示出100}和111}取向。
• [EN] AMIDE DERIVATIVES OF VALPROIC ACID AND USES THEREOF<br/>[FR] DÉRIVÉS AMIDE D'ACIDE VALPROÏQUE ET LEURS UTILISATIONS
  申请人：YISSUM RES DEV CO

  公开号：WO2011039746A1

  公开（公告）日：2011-04-07

  Amide derivatives of valproic acid are provided along their use in the treatment of epilepsy.

  戊二酸酰胺衍生物及其在癫痫治疗中的应用。
• Pharmaceutical formulations for the treatment and prevention of trauma-induced neuropathology and neurodegeneration
  申请人：Sapna Life Sciences Corporation

  公开号：US10201569B2

  公开（公告）日：2019-02-12

  Novel multi-component formulations, procedures and methods for use in treating neuropathology and neurodegeneration incident to trauma are provided. Multi-component formulations of the invention comprise biologically active forms of any two, any three, or all four of at least one neurosteroid or neuroactive steroid, such as progesterone or synthetic progestin, at least one anti-epileptic or anticonvulsant, such as gabapentin, pregabalin or valproic acid, at least one NK-1 receptor antagonist, such as aprepitant, casopitant or vestipitant, at least one lithium-containing or lithium-related drug. The provided formulations are configured or adapted to prevent or reduce the incidence and severity of neurological damage caused by trauma, or the risk of such damage. Formulations, procedures and methods of the invention advantageously effect both neuroprotective actions to prevent or reduce secondary injuries, and neurotrophic actions to repair and restore cells and tissues affected by the trauma, and are especially useful in treating injury or trauma to nerve cells, to neural support cells and to neural support tissues.

  本发明提供了用于治疗创伤引起的神经病理学和神经变性的新型多组分制剂、程序和方法。本发明的多组分制剂包括至少一种神经类固醇或神经活性类固醇（如黄体酮或合成孕激素）、至少一种抗癫痫药或抗惊厥药（如加巴喷丁、普瑞巴林或丙戊酸）、至少一种NK-1受体拮抗剂（如阿普瑞坦、卡索匹坦或马替匹坦）、至少一种含锂药物或与锂相关的药物的任意两种、任意三种或全部四种的生物活性形式。所提供的制剂经配置或调整后可预防或降低创伤引起的神经损伤的发生率和严重程度，或降低这种损伤的风险。本发明的制剂、程序和方法既能起到预防或减少二次损伤的神经保护作用，又能起到修复和恢复受创伤影响的细胞和组织的神经营养作用，特别适用于治疗神经细胞、神经支持细胞和神经支持组织的损伤或创伤。
• Kondakowa; Katznelson, Doklady Akademii Nauk SSSR, vol. 18, p. 272
  作者：Kondakowa、Katznelson

  DOI：——

  日期：——
• AMIDE DERIVATIVES OF VALPROIC ACID AND USES THEREOF
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.

  公开号：EP2483237B1

  公开（公告）日：2016-05-11