N-[2-palmitoyloxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide Monohydrochloride

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-[2-palmitoyloxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide Monohydrochloride
• 英文别名: N-[2-Palmitoyloxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide Monohydrochloride；[1-[(Z)-[amino(pyridin-3-yl)methylidene]amino]oxy-3-piperidin-1-ylpropan-2-yl] hexadecanoate;hydrochloride
• 化学式: C₃₀H₅₂N₄O₃*ClH
• 分子量: 553.229
• InChiKey: COAVVROLAAUPRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.02
• 重原子数：
  38
• 可旋转键数：
  22
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  90
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-3-pyridine-carboximidamide 、 棕榈酰氯 在 三乙胺 作用下， 以 氯仿 、 乙酸乙酯 为溶剂， 生成 N-[2-palmitoyloxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide Monohydrochloride
  参考文献：
  名称：

  Pharmaceutical products for curing and preventing illnesses connected

  摘要：

  本发明涉及一种治疗或预防由受损内皮细胞引起的疾病的方法，其中该方法包括向患者施用包含以下通式（I）的羟胺衍生物的产品： ##STR1## 但要注意，在通式（I）的化合物中，当X包括一个--NR^3R^4基团，而Y包括一个羟基时，X基团与Y取代基会缩合形成由通式（III）表示的分子内环： ##STR2##

  公开号：

  US06143741A1

文献信息

• Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof
  申请人：Biorex Research & Development Co.

  公开号：US06653326B1

  公开（公告）日：2003-11-25

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively; an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxyl amine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  提供了一种通过细胞增加分子伴侣的表达和/或增强细胞中分子伴侣活性的方法。该方法包括将暴露于诱导细胞表达分子伴侣的生理应激的细胞用有效量的某种羟胺衍生物进行处理，以增加应激。或者；可以在细胞暴露于诱导细胞表达分子伴侣的生理应激之前向细胞施加羟胺衍生物。最好，施加羟胺衍生物的细胞是真核细胞。羟胺衍生物对应于式（I）或（II）。本发明还提供了新颖的羟胺衍生物，属于式（I）和（II）范围内，以及包含所述化合物的药用和/或化妆品组合物。
• Use of hydroxylamine derivatives, and method and preparations for increasing the tolerance of field crops against weather stresses
  申请人：——

  公开号：US20010051630A1

  公开（公告）日：2001-12-13

  This invention relates to the use of hydroxylamine derivatives of general formula (I), wherein R 1 represents phenyl, N-heteroaryl, S-heteroaryl or a naphthyl group any of which may be unsubstituted or substituted, an unsubstituted or substituted phenylamino or alkylamino or lower alkoxy; X represents halo, amino or an unsubstituted or substituted phenylamino group, or amino substituted with one or two lower alkyl or a hydroxy group, provided that if R 1 represents unsubstituted or substituted phenylamino, alkylamino or lower alkoxy, then X is not halo; Y represents hydrogen, hydroxy or alkanoyloxy, with the proviso that simultaneously R 1 may not represent phenyl, halophenyl, alkoxyphenyl, N-heteroaryl or naphthyl, X may not represent halo, hydroxy or amino and Y may not represent hydrogen or hydroxy; R 2 and R 3 , independently from each other, represent hydrogen or lower alkyl group, provided that R 2 and R 3 are not hydrogen simultaneously, or R 2 and R 3 along with the adjacent nitrogen atom form a 5- to 7-membered saturated hetero ring, to increase the tolerance of cultivated plants against weather condition stresses, such as cold, frost and drought.

  本发明涉及使用羟胺衍生物的一般式(I)，其中R1代表苯基、N-杂环基、S-杂环基或萘基，其中任何一个可能未取代或取代，未取代或取代的苯氨基或烷基氨基或较低的烷氧基；X代表卤素、氨基或未取代或取代的苯氨基基团，或取代一或两个较低的烷基或羟基的氨基，但如果R1代表未取代或取代的苯氨基、烷基氨基或较低烷氧基，则X不是卤素；Y代表氢、羟基或脂肪酰氧基，但同时R1不能表示苯基、卤苯基、烷氧基苯基、N-杂环基或萘基，X不能表示卤素、羟基或氨基，Y不能表示氢或羟基；R2和R3相互独立地代表氢或较低的烷基，但要求R2和R3不能同时为氢，或者R2和R3与相邻的氮原子一起形成5-至7-成员的饱和杂环，以提高栽培植物对天气条件胁迫，如寒冷、霜冻和干旱的耐受性。
• [EN] HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE MOLECULAR CHAPERON PRODUCTION AND THE PREPARATION THEREOF<br/>[FR] DERIVES D'HYDROXYLAMINE UTILISES POUR AMELIORER LA PRODUCTION DE CHAPERONS MOLECULAIRES ET LEUR PREPARATION
  申请人：BIOREX KUTATÓ ÉS FEJLESZTÓ RT.

  公开号：WO1997016439A1

  公开（公告）日：1997-05-09

  (EN) A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, a hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which a hydroxylamine derivative is administered is a eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.(FR) Procédé visant à accroître l'expression d'un chaperon moléculaire par une cellule et/ou à intensifier l'activité de celui-ci dans les cellules. Le procédé consiste à traiter une cellule qui est exposée à une tension physiologique induisant l'expression d'un chaperon moléculaire par la cellule avec une quantité efficace d'un certain dérivé d'hydroxylamine afin d'augmenter la tension. Selon une autre variante, un dérivé d'hydroxylamine peut être administré à une cellule avant d'être exposé à une tension physiologique induisant l'expression d'un chaperon moléculaire par la cellule. De préférence, la cellule dans laquelle est administré le dérivé d'hydroxylamine est une cellule eucaryote. Le dérivé d'hydroxylamine correspond aux formules (I) et (II). L'invention se rapporte également à des nouveaux dérivés d'hydroxylamine relevant des formules (I) et (II), ainsi qu'à des compositions pharmaceutiques et/ou cosmétiques comprenant ces composés.

  本发明提供了一种增加细胞分子伴侣表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理受到诱导细胞分子伴侣表达的生理压力的细胞，以增加压力。或者，在细胞暴露于诱导细胞分子伴侣表达的生理压力之前，可以向细胞中注入羟胺衍生物。最好注入羟胺衍生物的细胞是真核细胞。该羟胺衍生物对应于式（I）或（II）。本发明还提供了在式（I）和（II）范围内的新的羟胺衍生物，以及包含这些化合物的药物和/或化妆品组合物。
• Method of enhancing cellular production of molecular chaperon, hydroxylamine derivatives useful for enhancing the chaperon production and the preparation thereof
  申请人：Biorex Research & Development Co.

  公开号：US20040067940A1

  公开（公告）日：2004-04-08

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  提供了一种通过细胞增加分子伴侣表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理受到诱导细胞分子伴侣表达的生理应激的细胞，以增加应激。或者，在细胞暴露于诱导其表达分子伴侣的生理应激之前，可以向细胞施用羟胺衍生物。最好，施用羟胺衍生物的细胞是真核细胞。羟胺衍生物对应于式(I)或(II)。该发明还提供了落在式(I)和(II)范围内的新羟胺衍生物，以及包含上述化合物的药物和/或化妆品组合物。
• Method of enhancing cellular production of molecular chaperone, hydroxylamine derivatives useful for enhancing the chaperone production and the preparation thereof
  申请人：CytRx Corporation

  公开号：US07745465B2

  公开（公告）日：2010-06-29

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  提供了一种通过细胞增加分子伴侣的表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理暴露于诱导细胞分子伴侣表达的生理应激下的细胞，以增加压力。另外，可以在细胞暴露于诱导细胞分子伴侣表达的生理应激之前给细胞施加羟胺衍生物。最好，接受羟胺衍生物处理的细胞是真核细胞。羟胺衍生物对应于公式（I）或（II）。本发明还提供了落在公式（I）和（II）范围内的新型羟胺衍生物，以及包含所述化合物的药物和/或化妆品组合物。