N-(2,3-dihydroxypropyl)-N-dodecyl Hexadecanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(2,3-dihydroxypropyl)-N-dodecyl Hexadecanamide
• 英文别名: N-(2,3-dihydroxypropyl)-N-dodecylhexadecanamide
• 化学式: C₃₁H₆₃NO₃
• 分子量: 497.846
• InChiKey: NPGOHQVDEMDHBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.3
• 重原子数：
  35
• 可旋转键数：
  28
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  棕榈酸甲酯 、 3-(十二烷基氨基)丙烷-1,2-二醇 在 氢氧化钾 作用下， 生成 N-(2,3-dihydroxypropyl)-N-dodecyl Hexadecanamide
  参考文献：
  名称：

  Synthetic ceramides and their use in cosmetic compostions

  摘要：

  一种新型伪神经酰胺，具有在水溶液中改善的分散性，并且可以通过经济的制造工艺生产。还公开了生产新型伪神经酰胺和含有新型伪神经酰胺的化妆品组合物的方法。

  公开号：

  US05476671A1

文献信息

• EMULSIFIED COMPOSITION
  申请人：Kao Corporation

  公开号：EP2452668A1

  公开（公告）日：2012-05-16

  The emulsion composition of the present invention contains (A) 0.001 to 10 wt.% of an organic compound having two or more hydroxyl groups, an inorganic value of 220 to 450, and an organic value of 300 to 1,000; (B) 0.001 to 10 wt.% of an organic compound having one hydroxyl group, an inorganic value of 100 to 200, and an organic value of 280 to 700; (C) 0.001 to 10 wt.% of a compound represented by formula (2): wherein R1 is a C4 to C30 hydrocarbon group; Z is a methylene group, a methine group, or an oxygen atom; X1, X2, X3 is a hydrogen atom, a hydroxyl group, or an acetoxy group; X4 is a hydrogen atom, an acetyl group, or a glyceryl group; each of R2 and R3 a hydrogen atom, a hydroxyl group, a hydroxymethyl group, or an acetoxymethyl group; R4 is a C5 to C60 hydrocarbon group; and R5 is a hydrogen atom or a hydrocarbon group containing 1 to 30 carbon atoms in total; (D) 0.00012 to 10 wt.% of at least one compound selected from the group consisting of a nonionic surfactant having a polyoxyethylene group and an HLB of 10 or higher, an ionic surfactant, and a sphingosine salt; (E) 0.003 to 15 wt.% of at least one compound selected from the group consisting of a sugar alcohol selected from the group consisting of erythritol, threitol, xylitol, and mannitol, a disaccharide, and a trisaccharide; and (F) water.

  本发明的乳液组合物含有 (A) 0.001 至 10 重量百分比的具有两个或两个以上羟基的有机化合物，无机值为 220 至 450，有机值为 300 至 1,000； (B) 0.001 至 10 重量百分比的有机化合物，具有一个羟基，无机物含量为 100 至 200，有机物含量为 280 至 700； (C) 0.001 至 10 重量百分比的式(2)所代表的化合物： 其中 R1 是 C4 至 C30 的烃基；Z 是亚甲基、亚甲基或氧原子；X1、X2、X3 是氢原子、羟基或乙酰氧基；X4 是氢原子、乙酰基或甘油基；R2和R3各自为氢原子、羟基、羟甲基或乙酰氧甲基；R4为C5至C60烃基；R5为氢原子或共含有1至30个碳原子的烃基； (D) 0.00012 至 10 重量％的至少一种选自以下组别的化合物：具有聚氧乙烯基团且 HLB 为 10 或更高的非离子表面活性剂、离子表面活性剂和鞘氨醇盐； (E) 0.003 至 15 重量百分比的至少一种化合物，该化合物选自由赤藓糖醇、 苏糖醇、木糖醇和甘露糖醇、二糖和三糖组成的组；以及 (F) 水。
• COSMETIC
  申请人：Kao Corporation

  公开号：EP2662071A1

  公开（公告）日：2013-11-13

  A cosmetic comprising the following components (A), (B), (C) and (D): (A) 0.001 to 50 % by weight of an organic acid represented by a general formula (1), wherein R1 denotes a residue derived from a natural sterin having one hydroxy group or a hydrogenated product thereof, or a residue derived from bile acid in which the hydroxyl hydrogen atom is removed; R2 denotes a divalent hydrocarbon group having 1 to 24 carbon atoms; and M denotes a hydrogen atom, an alkali metal, an alkaline earth metal, ammonium, alkanolammonium having 2 to 9 carbon atoms in total, alkylammonium or alkenylammonium having 1 to 22 carbon atoms in total, a pyridinium substituted with an alkyl group or an alkenyl group having 1 to 18 carbon atoms, or a basic amino acid; (B) 0.001 to 20% by weight of a base; (C) 0.0001 to 50% by weight of a ceramide; and (D) water, and comprising, as a component (E), an acid other than the component (A) in a content satisfying a relationship: 0 ≤ (E)/(A) < 0.2, and having pH of 6 to 11.

  一种化妆品，由以下成分组成(A)、(B)、(C)和(D)： (A) 0.001-50%（按重量计）由通式（1）表示的有机酸，其中 R1 表示从具有一个羟基的天然固醇提取的残留物或其氢化产物，或从胆汁酸提取的残留物，其中的羟基氢原子被去除；R2 表示具有 1-24 个碳原子的二价烃基；M 表示氢原子、碱金属、碱土金属、铵、共 2 至 9 个碳原子的烷醇铵、共 1 至 22 个碳原子的烷基铵或烯基 铵、被 1 至 18 个碳原子的烷基或烯基取代的吡啶鎓或碱性氨基酸； (B) 0.001 至 20%（重量百分比）的碱； (C) 0.0001 至 50%（重量百分比）的神经酰胺；以及 (D) 水、 作为成分(E)，还包括成分(A)以外的一种酸，其含量满足以下关系：0 ≤ (E)/(A) < 0.2，pH 值为 6 至 11。
• COSMETIC comprising a ceramide
  申请人：Kao Corporation

  公开号：EP2662071B1

  公开（公告）日：2018-06-20
• VESICLE COMPOSITION
  申请人：Kao Corporation

  公开号：EP2692334B1

  公开（公告）日：2015-11-04
• Reverse Vesicle
  申请人：Okubo Koji

  公开号：US20110263714A1

  公开（公告）日：2011-10-27

  The reverse vesicle composition of the present invention includes (A) a sphingosine represented by formula (1) (wherein R 1 represents a C4 to C30 linear alkyl group which may be substituted by a hydroxyl group, a carbonyl group, or an amino group; Y represents a methylene group, a methine group, or an oxygen atom; each of X 1 , X 2 , and X 3 represents a hydrogen atom, a hydroxyl group, or an acetoxy group; X 4 represents a hydrogen atom, an acetyl group, or a glyceryl group, or forms an oxo group together with the adjacent oxygen atom (wherein when Y is a methine group, one of X 1 and X 2 is a hydrogen atom, and the other is absent, and when X 4 forms an oxo group, X 3 is absent); each of R 2 and R 3 represents a hydrogen atom, a hydroxyl group, a hydroxymethyl group, or an acetoxymethyl group; a is a number of 2 or 3; each of (R) a represents a hydrogen atom, an amidino group, or a linear-chain alkyl group optionally having a substituent selected from among a hydroxyl group, a hydroxyalkoxy group, an alkoxy group, and an acetoxy group and containing 1 to 8 carbon atoms in total; and the broken line represents an optional unsaturated bond), (B) a C16 to C30 fatty acid, (C) a hydrocarbon oil, (D) an ester oil which is in liquid form at 25° C., and (F) water, wherein the ratio by mass of ingredient (C) to ingredient (D) satisfies the following relationship: 1≦(C)/(D)<1000, and the composition contains a surfactant having a molecular weight of 1,000 or less in an amount of 1 mass % or less.