The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, and N-oxides thereof,that are useful as single pharmaceutical agents or in combination with one or more additional pharmaceutical agents, such as, an inhibitor of DPP-IV, a biguanide, an alpha-glucosidase inhibitor, an insulin analogue, a sulfonylurea, an SGLT2 inhibitor, a meglitinide, a thiazolidinedione, or an anti-diabetic peptide analogue, in the treatment of, for example, a disorder selected from: a GPR119-receptor-related disorder; a condition ameliorated by increasing secretion of an incretin; a condition ameliorated by increasing a blood incretin level; a condition characterized by low bone mass; a neurological disorder; a metabolic-related disorder; type 2 diabetes; obesity; and complications related thereto.
本发明涉及式(I)的化合物及其药学上可接受的盐、溶剂化合物、
水合物和N-氧化物,这些化合物可作为单一药物代理或与一个或多个额外的药物代理结合使用,例如
DPP-IV的
抑制剂、双胍类药物、α-
葡萄糖苷酶
抑制剂、
胰岛素类似物、磺
脲类药物、SGLT2
抑制剂、
噻嗪二
酮类药物或抗糖尿病肽类似物,用于治疗例如从以下选择的疾病中选择的疾病:GPR119受体相关疾病;通过增加促胰高血糖素分泌而改善的状况;通过增加血液促胰高血糖素
水平而改善的状况;低骨量状况;神经系统疾病;与代谢相关的疾病;2型糖尿病;肥胖症;以及相关并发症。