N-(3-dimethylaminopropyl)crotonic acid amide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(3-dimethylaminopropyl)crotonic acid amide
• 英文别名: (E)-N-[3-(dimethylamino)propyl]but-2-enamide
• 化学式: C₉H₁₈N₂O
• 分子量: 170.255
• InChiKey: YJZYDJLNWSMVKJ-GQCTYLIASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N,N-二甲基-1,3-二氨基丙烷 在 sodium hydroxide 作用下， 以76%的产率得到N-(3-dimethylaminopropyl)crotonic acid amide
  参考文献：
  名称：

  Process for the manufacture of .alpha.,.beta.-unsaturated N-substituted

  摘要：

  翻译结果如下： 生产通式为 ##STR1## 的 α,β-不饱和N-取代羧酸酰胺的方法，其中R.sup.1代表H或CH.sub.3，R.sup.2代表H或CH.sub.3，Y代表具有2-30个碳原子的直链或支链有机二价基团，R.sup.3代表H或公式为--N(R.sup.4)(R.sup.5)的胺的自由基，其中R.sup.4和R.sup.5代表具有1至4个碳原子的烷基自由基，通过将通式为 ##STR2## 的 β-取代羧酸酰胺与通式为 H.sub.2 N--(Y)--R.sub.3 III 的胺在100°C至200°C的温度范围内反应，优选120°C至175°C，同时排除氨，并在催化剂、水或醇的存在下加热所得的N-取代β-羟基羧酸或β-烷氧羧酸酰胺，分别脱水分解。水在100°C至250°C的温度下，在如磷酸等酸性催化剂或如氢氧化钠等碱性催化剂的作用下分解，醇在70°C至150°C的温度下，在如氢氧化钠或氢氧化钾等碱性催化剂的作用下分解。通过蒸馏分离反应产物，可选地在真空条件下进行。

  公开号：

  US04237067A1

文献信息

• Continuous Method for Producing Amides of Ethylenically Unsaturated Carboxylic Acids
  申请人：Krull Matthias

  公开号：US20110089020A1

  公开（公告）日：2011-04-21

  The invention relates to a continuous method for producing amides, according to which at least one carboxylic acid of formula (I) R 3 -COON (I), wherein R 3 is an optionally substituted alkenyl group comprising between 2 and 4 carbon atoms, is reacted with at least one amine of formula (II) HNR 1 R 2 (II), wherein R 1 and R 2 are independently hydrogen or a hydrocarbon radical comprising between 1 and 100 C atoms, to form an ammonium salt and/or a Michael adduct, and said ammonium salt is then reacted to form a carboxylic acid amide. under microwave irradiation in a reaction pipe, the longitudinal axis of the pipe being oriented in the direction of propagation of the microwaves of a monomode microwave applicator.

  该发明涉及一种连续生产酰胺的方法，根据该方法，至少一个具有化学式（I）R3-COON（I）的羧酸发生反应，其中R3是一个由2至4个碳原子组成的可选择取代的烯基基团，与至少一个具有化学式（II）HNR1R2（II）的胺发生反应，其中R1和R2独立地是氢或包含1至100个碳原子的烃基团，形成铵盐和/或迈克尔加合物，然后将所述铵盐反应形成羧酸酰胺，在微波辐射下在反应管内进行，管的纵轴朝向单模微波应用器的微波传播方向。
• Method For Producing Alkaline (Meth)Acrylamides
  申请人：Krull Matthias

  公开号：US20100032284A1

  公开（公告）日：2010-02-11

  The invention relates to a method for producing alkaline amides or imides of ethylenically unsaturated C 3 to C 6 carboxylic acids by reacting amines that contain at least one primary and/or secondary amino group and at least one tertiary amino group with ethylenically unsaturated C 3 to C 6 carboxlic acids to form an ammonium salt and said ammonium salt is subsequently converted into the alkaline amide or imide by means of microwave radiation, with the proviso that the primary and/or secondary amino group is devoid of alkoxy groups.

  该发明涉及一种通过将含有至少一个一次和/或二次氨基团和至少一个三次氨基团的胺与乙烯基不饱和的C3到C6羧酸反应，形成铵盐，然后通过微波辐射将所述铵盐转化为碱性酰胺或亚胺的方法。前提是一次和/或二次氨基团不含有烷氧基。
• COATING COMPOSITION, COATING FILM, LAMINATE, AND PROCESS FOR PRODUCTION OF LAMINATE
  申请人：Takanohashi Hiroaki

  公开号：US20120285528A1

  公开（公告）日：2012-11-15

  [Problem to be Solved] Provided is a coating composition excellent in antifouling properties, transparency and hydrophilicity and capable of maintaining surface hydrophilicity even at high temperature. [Solution] A coating composition containing (A) a metal oxide particle having a number average particle size of 1 nm to 400 nm, and (B) a polymer particle, in which the content of an aqueous-phase component in the component (B), represented by the following expression (I), is 20 mass % or less. The content of the aqueous-phase component (%)=(dry mass of a filtrate obtained by filtering the component (B) at a molecular cutoff of 50,000)×(100−total mass of solid content)/(mass of the filtrate−dry mass of the filtrate)×100/the total mass of solid content  (I).

  【待解决问题】提供一种涂层组合物，具有优异的防污性、透明性和亲水性，并能在高温下维持表面的亲水性。【解决方案】一种涂层组合物，包含(A)具有平均颗粒大小为1纳米至400纳米的金属氧化物颗粒，和(B)聚合物颗粒，其中(B)组分中水相组分的含量，由以下公式(I)表示，为20质量%或更少。水相组分的含量（%）=（在分子截留率为50,000的情况下过滤组分(B)获得的滤液的干质量）×（100-固体含量总质量）/（滤液的质量-滤液的干质量）×100/固体含量总质量。【翻译者注】涂层组合物是指用于表面涂层的材料混合物。
• Coating Composition, Coating Film, Laminate, and Process for Production of Laminate
  申请人：ASAHI KASEI E-MATERIALS CORPORATION

  公开号：US20150068603A1

  公开（公告）日：2015-03-12

  Provided is a coating composition excellent in antifouling properties, transparency and hydrophilicity, wherein the coating composition contains (A) a metal oxide particle having a number average particle size of 1 nm to 400 nm; and (B) a polymer particle, in which the content of an aqueous-phase component in the component (B), represented by the expression (I), is 20 mass % or less, where (I) (%)=(dry mass of a filtrate obtained by filtering the component (B) at a molecular cutoff of 50,000)×(100−total mass of solid content)/(mass of the filtrate−dry mass of the filtrate)×100/the total mass of solid content.

  提供的是一种涂层组合物，具有优异的防污性、透明性和亲水性，其中涂层组合物包含（A）一种具有1纳米至400纳米的平均颗粒数的金属氧化物颗粒；和（B）一种聚合物颗粒，在其中，组分（B）中水相成分的含量，由表达式（I）表示，为20质量%或以下，其中（I）（%）=（在分子截止50,000处过滤组分（B）得到的滤液的干质量）×（100-固体含量的总质量）/（滤液的质量-滤液的干质量）×100/固体含量的总质量。
• Coating Composition, Coating Film, Laminate, and Process for Manufacturing the Laminate
  申请人：Asahi Kasei E-materials Corporation

  公开号：US20150079292A1

  公开（公告）日：2015-03-19

  Provided is a coating composition excellent in antifouling properties, transparency and hydrophilicity, wherein the coating composition contains (A) a metal oxide particle having a number average particle size of 1 nm to 400 nm; and (B) a polymer particle, in which the content of an aqueous-phase component in the component (B), represented by the expression (I), is 20 mass % or less, where (I) (%)=(dry mass of a filtrate obtained by filtering the component (B) at a molecular cutoff of 50,000)×(100−total mass of solid content)/(mass of the filtrate−dry mass of the filtrate)×100/the total mass of solid content.

  提供的是一种具有优异防污性、透明度和亲水性的涂层组合物，其中涂层组合物包含（A）平均粒径为1纳米至400纳米的金属氧化物颗粒；和（B）聚合物颗粒，其中组分（B）中水相成分的含量由式（I）表示，式中水相成分的质量百分含量为20%或以下，其中(I) (%) =（在分子截止50,000的条件下过滤组分（B）得到的滤液的干质量）×（100-固含量总质量）/（滤液质量-滤液干质量）×100/固含量总质量。