5-pyridin-4-ylmethylene-imidazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-pyridin-4-ylmethylene-imidazolidine-2,4-dione
• 英文别名: (5Z)-5-(pyridin-4-ylmethylidene)imidazolidine-2,4-dione
• 化学式: C₉H₇N₃O₂
• 分子量: 189.173
• InChiKey: JFEGQPTZCCZRSJ-ALCCZGGFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-吡啶甲醛 、 海因 在 sodium carbonate 、 聚甘氨酸 作用下， 以 水 为溶剂， 反应 5.0h， 生成 5-pyridin-4-ylmethylene-imidazolidine-2,4-dione
  参考文献：
  名称：

  Synthesis and potential coanthracyclinic activity of pyridylmethylene and indolylmethylene lactams

  摘要：

  The synthesis of pyridylmethylene lactams and indolylmethylene-2 indolinones is reported. These compounds were tested for their cytotoxic and positive inotropic activity. The presence of both the effects (coanthracyclinic activity) was confirmed in some of the indolylmethylene-2-indolinones. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80015-4

文献信息

• cGAS antagonist compounds
  申请人：ImmuneSensor Therapeutics, Inc.

  公开号：US10947206B2

  公开（公告）日：2021-03-16

  Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

  所公开的是作为 cGAS 拮抗剂的新型式 I 化合物、该化合物的制备方法、包含该化合物的药物组合物及其在医学治疗中的用途。
• Synthesis and potential coanthracyclinic activity of pyridylmethylene and indolylmethylene lactams
  作者：Aldo Andreani、Alessandra Locatelli、Alberto Leoni、Rita Morigi、Michele Chiericozzi、Alessandra Fraccari、Iraklis Galatulas、Gaetano Salvatore

  DOI：10.1016/s0223-5234(99)80015-4

  日期：1998.11

  The synthesis of pyridylmethylene lactams and indolylmethylene-2 indolinones is reported. These compounds were tested for their cytotoxic and positive inotropic activity. The presence of both the effects (coanthracyclinic activity) was confirmed in some of the indolylmethylene-2-indolinones. (C) Elsevier, Paris.