噻唑并[5,4-c]异噻唑(9CI) | 28875-47-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 噻唑并[5,4-c]异噻唑(9CI)
• 中文别名: 盐酸布他拉胺
• 英文名称: Butalaminhydrochlorid
• 英文别名: N,N-dibutyl-N'-(3-phenyl-1,2,4-oxadiazol-5-yl)ethylenediamine hydrochloride；Butalamine hydrochloride；N',N'-dibutyl-N-(3-phenyl-1,2,4-oxadiazol-5-yl)ethane-1,2-diamine;hydrochloride
• CAS: 28875-47-0
• 化学式: C₁₈H₂₈N₄O*ClH
• 分子量: 352.907
• InChiKey: ZCEDBAQIHPGWNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.36
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  55.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Solution-based transdermal drug delivery system comprising a vasodilator
  申请人：BioChemics, Inc.

  公开号：EP1201230A2

  公开（公告）日：2002-05-02

  An efficient transdermal delivery system for delivering an active ingredient to the blood supply of a living body, comprising a vasodilator, an active ingredient, and a permeation enhancer for the active ingredient. The components of this mixture are combined in a manner that dissolves them into solution, eliminating the need for a polymeric binding agent and thus diminishing the total molecular weight of the mixture and increasing the penetration and delivery efficiency of the active drug molecules.

  一种将活性成分输送到活体血液供应的高效透皮给药系统，由血管扩张剂、活性成分和活性成分渗透促进剂组成。 这种混合物的各组分以溶解到溶液中的方式结合在一起，无需使用聚合物结合剂，从而减少了混合物的总分子量，提高了活性药物分子的渗透和输送效率。
• Methods and compositions for tattoo removal
  申请人：BioChemics, Inc.

  公开号：US10322077B2

  公开（公告）日：2019-06-18

  Methods and formulations for removing a tattoo by using a cell disrupter in combination with a vasodilator, and optionally one or more of an osmotic modifying agent, a chelation agent, and an occlusive modifying agent. Embodiments optionally further include using one or more of an antibiotic, anesthetic, penetration enhancer, excipient, carrier and vehicle.

  用于去除纹身的方法和制剂，其方法是将细胞破坏剂与血管扩张剂以及可选的渗透调节剂、螯合剂和闭塞调节剂中的一种或多种结合使用。本发明的实施方案还可选择使用抗生素、麻醉剂、渗透促进剂、赋形剂、载体和载体中的一种或多种。
• Transdermally-delivered combination drug therapy for pain
  申请人：BioChemics, Inc.

  公开号：US10624867B2

  公开（公告）日：2020-04-21

  The invention provides a topical formulation for treating pain comprising a nonsteroidal anti-inflammatory agent or a Cox-2 inhibitor and a gabapentin family member.

  本发明提供了一种用于治疗疼痛的外用制剂，其中包含一种非甾体抗炎剂或 Cox-2 抑制剂和一种加巴喷丁家族成员。
• Transdermal drug delivery using an osmolyte and vasoactive agent
  申请人：BioChemics, Inc.

  公开号：US10751309B2

  公开（公告）日：2020-08-25

  A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.

  一种用于在哺乳动物（例如病人）的皮肤或其他外部区域或内部施用生物活性物质的制剂和方法，包括一种血管活性剂、一种渗透剂和一种活性成分。制剂具有足够的吸湿性，以便在被皮肤吸收时产生高张力状态。将制剂涂抹在皮肤上时，血管活性剂可被输送到真皮层，从而接触到患者的血管。
• Pain therapy cream with deep tissue delivery system
  申请人：Shapiro Scott

  公开号：US10806790B1

  公开（公告）日：2020-10-20

  The invention provides a pain therapy cream comprising an anhydrous topical delivery formulation for percutaneous absorption comprising an anhydrous carrier medium, a chemical exfoliant, a penetration enhancer, and one or more pain killing agent selected from the group consisting of an analgesic, anesthetic, anti-inflammatory, or antipruritic agent, a phytochemical and other painkilling active ingredients, and methods of using the pain therapy cream.

  本发明提供了一种止痛膏，包括一种用于经皮吸收的无水局部给药配方，该配方由无水载体介质、化学去角质剂、渗透促进剂和一种或多种止痛剂组成，这些止痛剂选自镇痛剂、麻醉剂、抗炎剂或止痒剂、植物化学物质和其他止痛活性成分组成的组，本发明还提供了使用这种止痛膏的方法。