2-bromomethyl-4-nitro-phenetole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-bromomethyl-4-nitro-phenetole
• 英文别名: ω-Brom-5-nitro-2-aethoxy-toluol；5-Nitro-2-aethoxy-benzylbromid；2-Brommethyl-4-nitro-phenetol；5-Nitro-2-aethoxy-1-brommethyl-benzol；2-Bromomethyl-1-ethoxy-4-nitrobenzene；2-(bromomethyl)-1-ethoxy-4-nitrobenzene
• 化学式: C₉H₁₀BrNO₃
• 分子量: 260.087
• InChiKey: KTOMZFKDXSUKTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-bromomethyl-4-nitro-phenetole 在 sodium ethanolate 、 permanganate(VII) ion 、 溶剂黄146 作用下， 生成 2-ethoxy-5-nitrobenzoic acid
  参考文献：
  名称：

  Kliegl; Hoelle, Chemische Berichte, 1926, vol. 59, p. 906

  摘要：

  DOI：
• 作为产物：
  描述：

  1-ethoxy-2-ethoxymethyl-4-nitro-benzene 在 氢溴酸 、 溶剂黄146 作用下， 生成 2-bromomethyl-4-nitro-phenetole
  参考文献：
  名称：

  Kliegl; Hoelle, Chemische Berichte, 1926, vol. 59, p. 906

  摘要：

  DOI：

文献信息

• Selective Apoptotic Induction in Cancer Cells Including Activation of Procaspase-3
  申请人：Hergenrother J. Paul

  公开号：US20070049602A1

  公开（公告）日：2007-03-01

  Compounds and related methods for synthesis, and the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3, and particular embodiments are capable of direct activation of procaspase-3 and procaspase-7 to the effector forms of caspase-3 and caspase-7. Procaspase-3 levels can vary among cancer cell types; several types have relatively high levels and can have increased susceptibility to chemotherapy by compounds and methods herein. Therapeutic applications are relevant for a variety of cancer conditions and cell types, e.g. breast, lung, brain, colon, renal, adrenal, melanoma, and others.
• Compositions and Methods Including Cell Death Inducers and Procaspase Activation
  申请人：HERGENROTHER Paul J.

  公开号：US20110257398A1

  公开（公告）日：2011-10-20

  Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.
• COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20170105989A1

  公开（公告）日：2017-04-20

  Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.
• US9522901B2
  申请人：——

  公开号：US9522901B2

  公开（公告）日：2016-12-20
• Kliegl; Hoelle, Chemische Berichte, 1926, vol. 59, p. 906
  作者：Kliegl、Hoelle

  DOI：——

  日期：——