钠硫代乙酸盐 | 34832-35-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 钠硫代乙酸盐
• 英文名称: sodium thioacetate
• 英文别名: thioacetic acid sodium salt；sodium;ethanethioate
• CAS: 34832-35-4
• 化学式: C₂H₃OS*Na
• 分子量: 98.101
• InChiKey: RBBWNXJFTBCLKT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.92
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  18.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  钠硫代乙酸盐 在 碘 作用下， 以86%的产率得到二乙酰基二硫醚
  参考文献：
  名称：

  迈向分子大小的修补玩具建筑套装。从 [1.1.1]propellane 制备末端官能化的 [n]staffane

  摘要：

  描述了一种在一端或两端官能化的 [n]staffanes（[1.1.1]propellane 的低聚物 n=1-5）的简便但低场合成，并总结了它们的性质。取代基为-COOCH 3 、-nC 4 H 9 、-C 6 H 5 、-Br、-I 和-SCOCH 3 ，并证明了它们向其他取代基如-COOH、-COCH 3 和-SH 的转化。建议这些棒状分子将有助于开发类似于儿童玩具建筑套装的分子大小的土木工程建筑套装

  DOI：

  10.1021/ja00028a029
• 作为产物：
  描述：

  1-乙酰基-1H-苯并噻唑 在 sodium hydrogen sulfide 作用下， 以 水 为溶剂， 反应 5.0h， 以97%的产率得到钠硫代乙酸盐
  参考文献：
  名称：

  不含催化剂和有机溶剂的水中硫代酸合成

  摘要：

  在室温下，由水中易得的酰基苯并三唑和氢硫化钠可高产率合成硫代酸和硫代氨基酸。新方法的特点是反应条件温和，收率高，反应时间短，并且不涉及有机溶剂或碱的使用。该反应是环境友好的，并且后处理步骤简单并且不需要色谱分离。

  DOI：

  10.1016/j.tetlet.2019.06.061
• 作为试剂：
  描述：

  (3aS,6aR)-1,3-二苄基四氢-1H-呋喃并[3,4-d]咪唑-2,4-二酮 在 钠硫代乙酸盐 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.75h， 以72%的产率得到(3aS-顺式)-1,3-二苄基四氢-1H-噻吩并[3,4-d]咪唑-2,4-二酮
  参考文献：
  名称：

  Total synthesis of (+)-biotin via a quinine-mediated asymmetric alcoholysis of meso-cyclic anhydride strategy

  摘要：

  A concise asymmetric total synthesis of (+)-biotin 1 has been accomplished in which the absolute stereochemistry of C-3a, C-6a of 1 was established by utilizing an efficient and practical quinine-mediated asymmetric alcoholysis of meso-cyclic anhydride 2 in a single step, the C-4 stereochemistry was installed by a direct stereoselective ionic hydrogenation of the thiolactol 7. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.05.020

文献信息

• Solid-phase versus solution synthesis of asymmetrically disubstituted furazano[3,4-b]pyrazines
  作者：E. Fernández、S. Garcı́a-Ochoa、S. Huss、A. Mallo、J.M. Bueno、F. Micheli、A. Paio、E. Piga、P. Zarantonello

  DOI：10.1016/s0040-4039(02)00913-9

  日期：2002.7

  Herein we describe a straightforward solid-phase synthesis directed towards the preparation of families of asymmetrically disubstituted furazano[3,4-b]pyrazines by stepwise displacement of the two chlorine atoms in 5,6-dichlorofurazano[3,4-b]pyrazine by nucleophiles. This synthesis has avoided selectivity problems found in solution chemistry.

  本文中，我们描述针对对称二取代furazano [3,4的家庭的制备简单的固相合成b在5,6- dichlorofurazano [3,4]由两个氯原子的逐步位移吡嗪b ]吡嗪通过亲核试剂。该合成避免了在溶液化学中发现的选择性问题。
• [EN] SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP<br/>[FR] MODULATEURS SELECTIFS DES RECEPTEURS OESTROGENIQUES CONTENANT UN GROUPE PHENYLSULFONYLE
  申请人：LILLY CO ELI

  公开号：WO2004009086A1

  公开（公告）日：2004-01-29

  The present invention relates to a selective estrogen receptor modulator of formula I or a pharmaceutical acid addition salt thereof; useful, e.g., for treating endometriosis and/or uterine leiomyoma/leiomyomata.

  本发明涉及式I的选择性雌激素受体调节剂或其药用酸盐加合物；例如，用于治疗子宫内膜异位症和/或子宫平滑肌瘤。
• 4(3H)-Quinazolinone derivatives, process for production thereof, and
  申请人：Ishikawa; Masayuki

  公开号：US04451467A1

  公开（公告）日：1984-05-29

  The 4(3H)-quinazolinone compounds of the formula (I) ##STR1## wherein R.sub.1 and R.sub.3, independently from each other, represent a lower alkyl group; R.sub.2 represents a lower alkoxycarbonyl group; Q represents a phenyl group or a substituted phenyl group substituted by at least one member selected from the group consisting of halogen atoms, lower alkyl groups, lower alkoxy groups, di(lower)-alkylamino groups, a methylenedioxy group, a trifluoromethyl group, a hydroxyl group, and a nitro group; R.sub.4 represents a hydrogen atom or a lower alkyl group; R.sub.5 represents a member selected from the group consisting of a hydrogen atom, lower alkyl groups, lower halogenoalkyl groups, lower alkenyl groups, (lower)alkoxy(lower)alkyl groups, hydroxy(lower)alkyl groups, (lower)alkylthio(lower)alkyl groups, (lower)alkylsulfinyl(lower)alkyl groups, (lower)alkylsulfonyl(lower)alkyl groups, di(lower)alkylamino(lower)alkyl groups, a benzyl group, a phenethyl group, pyridyl(lower)alkyl groups, furfuryl groups, a phenyl group, and substituted phenyl groups substituted by a member selected from the group consisting of halogen atoms, lower alkyl groups, and lower alkoxy groups; and Z.sub.1 and Z.sub.2, independently from each other, represent an oxygen or sulfur atom; and an acid addition salt thereof; and a process for producing the same.

  化合物的中文翻译如下： 式(I)的4(3H)-喹唑啉酮化合物 其中R.sub.1和R.sub.3分别独立地代表低碳基团；R.sub.2代表低碳氧羰基团；Q代表苯基或被卤素原子、低碳基团、低碳氧基团、二(低碳基)氨基团、亚甲二氧基基团、三氟甲基基团、羟基和硝基等至少一种成员取代的取代苯基；R.sub.4代表氢原子或低碳基团；R.sub.5代表从氢原子、低碳基团、低卤代低碳基团、低烯基基团、(低碳基)氧基(低碳基)基团、羟基(低碳基)基团、(低碳基)硫基(低碳基)基团、(低碳基)亚砜基(低碳基)基团、二(低碳基)氨基(低碳基)基团、苄基、苯乙基、吡啶(低碳基)基团、呋喃基团、苯基和被卤素原子、低碳基团和低碳氧基团中的一种成员取代的取代苯基中选择的成员中的一种；Z.sub.1和Z.sub.2分别独立地代表氧或硫原子；以及其酸加盐；以及其生产方法。
• 2,6-Disubstituted penem compounds
  申请人：Bristol-Myers Company

  公开号：US04282150A1

  公开（公告）日：1981-08-04

  This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula ##STR1## wherein Y is hydrogen, halo or certain organic radicals and X represents certain hetero-interrupted substituted alkyl radicals. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.

  本发明涉及2-取代和2,6-二取代的戊二烯化合物，其化学公式如下：##STR1## 其中Y代表氢，卤素或某些有机基团，X代表某些杂原子打断的取代烷基基团。发明还包括上述化合物的药用可接受盐，以及上述化合物的衍生物，其中3位上的羧基被易于移除的酯保护基团所保护。本发明的化合物是强效的抗菌剂，或者可用作制备此类药物的中间体。
• Antibacterial agents, and 4-thio azetidinone intermediates
  申请人：Bristol-Myers Company

  公开号：US04272437A1

  公开（公告）日：1981-06-09

  This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula ##STR1## wherein Y is hydrogen, halo or certain organic substituents and X represents certain organic substituents. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.

  本发明涉及2-取代和2,6-二取代的青霉烯化合物，其公式为##STR1##，其中Y是氢、卤素或某些有机取代基，X代表某些有机取代基。发明还包括上述化合物的药用可接受盐和上述化合物的衍生物，其中3位的羧基被易于移除的酯保护基团所保护。本发明的化合物是强效的抗菌剂，或可用于制备此类药物的中间体。