methanol-acetic anhydride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: methanol-acetic anhydride
• 英文别名: 3-Hydroxypropanoyl 3-hydroxypropanoate
• 化学式: C₆H₁₀O₅
• 分子量: 162.142
• InChiKey: YNDLEGJDTYJKKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methanol-acetic anhydride 、 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  A Search for Quantitative Acylation of α-Trinositol (1d-myo-Inositol 1,2,6-tris(dihydrogen phosphate) Pentasodium Salt)

  摘要：

  The acylation of alpha-trinositol is very sensitive to reaction conditions. Competing condensation reactions may give pyrophosphates and cyclic phosphates. Treatment of a tert-ammonium salt corresponding to alpha-trinositol with carboxylic acid anhydride and DMAP gives a good yield of the expected esters.

  DOI：

  10.1080/07328309608005666
• 作为产物：
  描述：

  3-羟基丙酸 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 methanol-acetic anhydride
  参考文献：
  名称：

  A Search for Quantitative Acylation of α-Trinositol (1d-myo-Inositol 1,2,6-tris(dihydrogen phosphate) Pentasodium Salt)

  摘要：

  The acylation of alpha-trinositol is very sensitive to reaction conditions. Competing condensation reactions may give pyrophosphates and cyclic phosphates. Treatment of a tert-ammonium salt corresponding to alpha-trinositol with carboxylic acid anhydride and DMAP gives a good yield of the expected esters.

  DOI：

  10.1080/07328309608005666

文献信息

• Catalysts Conversion Of Hydroxypropionic Acid Or Its Derivatives To Acrylic Acid Or Its Derivatives
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：US20130274512A1

  公开（公告）日：2013-10-17

  Methods for catalytically dehydrating hydroxypropionic acid, hydroxypropionic acid derivatives, or mixtures thereof to acrylic acid, acrylic acid derivatives, or mixtures thereof with high yield and selectivity and without significant conversion to undesired side products, such as, acetaldehyde, propionic acid, and acetic acid, are provided. The catalysts are mixed condensed phosphates.

  提供了一种将羟基丙酸、羟基丙酸衍生物或二者混合物催化脱水制备丙烯酸、丙烯酸衍生物或二者的方法，具有高产率和选择性，并且不会显著转化为不希望的副产物，如乙醛、丙酸和乙酸，催化剂为混合凝缩磷酸盐。
• Methods for synthesis of alpha-d-gal (1~>3) gal-containing oligosaccharides
  申请人：——

  公开号：US20040058888A1

  公开（公告）日：2004-03-25

  This invention relates to reagents and methods for synthesis of biologically active di- and tri-saccharides comprising &agr;-D-Gal(1→3)-D-Gal. In particular the invention provides novel reagents, intermediates and processes for the solution or solid phase synthesis of &agr;-D-galactopyranosyl-(1→3)-D-galactose, and derivatives thereof. In one preferred embodiments the invention provides a protected monosaccharide building block of general formula (II): in which R 3 is methoxy or methyl; R 1 is H, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl; and R 2 is H, Fmoc, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4 -chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl. 1

  本发明涉及用于合成具有生物活性的二糖和三糖的试剂和方法，这些糖包括α-D-Gal(1→3)-D-Gal。特别地，本发明提供了用于溶液或固相合成α-D-半乳糖基-(1→3)-D-半乳糖及其衍生物的新试剂、中间体和工艺。在一个优选的实施例中，本发明提供了一种保护的单糖构建块，其通式为(II)：其中R3是甲氧基或甲基；R1是H、苯甲酰基、特戊酰基、4-氯苯甲酰基、乙酰基、氯乙酰基、乙酰乙酰基、4-甲基苯甲酰基、苄基、3,4-亚甲二氧基苄基、4-甲氧基苄基、4-氯苄基、4-乙酰氨基苄基或4-叠氮苄基；R2是H、芴甲氧羰基(Fmoc)、苯甲酰基、特戊酰基、4-氯苯甲酰基、乙酰基、氯乙酰基、乙酰乙酰基、4-甲基苯甲酰基、苄基、3,4-亚甲二氧基苄基、4-甲氧基苄基、4-氯苄基、4-乙酰氨基苄基或4-叠氮苄基。
• Method for conversion of beta-hydroxy carbonyl compounds
  申请人：Lilga A. Michael

  公开号：US20070219391A1

  公开（公告）日：2007-09-20

  A process is disclosed for conversion of salts of β-hydroxy carbonyl compounds forming useful conversion products including, e.g., α,β-unsaturated carbonyl compounds and/or salts of α,β-unsaturated carbonyl compounds. Conversion products find use, e.g., as feedstock and/or end-use chemicals.

  揭示了一种将β-羟基羰基化合物的盐转化为有用的转化产物的过程，包括α，β-不饱和羰基化合物和/或α，β-不饱和羰基化合物的盐。这些转化产物可以用作原料或最终用途的化学品。
• Process For Production Of Acrylic Acid Or Its Derivatives
  申请人：THE PROCTOR & GAMBLE COMPANY

  公开号：US20130274515A1

  公开（公告）日：2013-10-17

  Processes for the catalytic dehydration of hydroxypropionic acid, hydroxypropionic acid derivatives, or mixtures thereof to acrylic acid, acrylic acid derivatives, or mixtures thereof with high yield and selectivity and without significant conversion to undesired side products, such as, acetaldehyde, propanoic acid, and acetic acid, are provided.

  提供了将羟基丙酸，羟基丙酸衍生物或其混合物催化脱水成丙烯酸，丙烯酸衍生物或其混合物的过程，具有高产率和选择性，并且不会显著转化为不需要的副产物，例如乙醛，丙酸和乙酸。
• Catalysts For The Production Of Acrylic Acid Or Its Derivatives
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：US20130274095A1

  公开（公告）日：2013-10-17

  Catalysts for dehydrating hydroxypropionic acid, hydroxypropionic acid derivatives, or mixtures thereof to acrylic acid, acrylic acid derivatives, or mixtures thereof with high yield and selectivity, short residence time, and without significant conversion to undesired side products, such as, for example, acetaldehyde, propionic acid, and acetic acid, are provided. The catalysts are mixed protonated monophosphates. Methods of preparing the catalysts are also provided.

  提供用于将羟基丙酸，羟基丙酸衍生物或其混合物脱水为丙烯酸，丙烯酸衍生物或其混合物的催化剂，具有高收率和选择性，短停留时间，并且不会显著转化为不需要的副产物，例如乙醛，丙酸和乙酸。这些催化剂是混合质子化单磷酸盐。还提供了制备催化剂的方法。