2-(3-nitrosophenyl)acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-nitrosophenyl)acetic acid
• 英文别名: 3-nitrosophenylacetic acid；2-(3-Nitrosophenyl)acetic acid
• 化学式: C₈H₇NO₃
• 分子量: 165.148
• InChiKey: UHQMXYRNTJYJBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  66.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(3-nitrosophenyl)acetic acid 在 N-甲基吗啉 、 N-羟基-7-氮杂苯并三氮唑 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Photocontrolled chignolin-derived β-hairpin peptidomimetics

  摘要：

  报道了合成新型chignolin衍生肽，其中包括偶氮苯光开关[3-(3-氨甲基)苯基偶氮]苯乙酸（AMPP）。

  DOI：

  10.1039/c4cc10304a
• 作为产物：
  描述：

  3-硝基苯乙酸 在 氯化铵 、 锌 、 iron(III) chloride hexahydrate 作用下， 以 乙二醇甲醚 、 水 、 乙醇 为溶剂， 反应 2.75h， 以95%的产率得到2-(3-nitrosophenyl)acetic acid
  参考文献：
  名称：

  Photocontrolled chignolin-derived β-hairpin peptidomimetics

  摘要：

  报道了合成新型chignolin衍生肽，其中包括偶氮苯光开关[3-(3-氨甲基)苯基偶氮]苯乙酸（AMPP）。

  DOI：

  10.1039/c4cc10304a

文献信息

• Piperazines as P2X7 antagonists
  申请人：Betschmann Patrick

  公开号：US20080076924A1

  公开（公告）日：2008-03-27

  Novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, enantiomers thereof or prodrugs thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.

  化合物I式的新型化合物或其药学上可接受的盐、代谢物、异构体、对映体或前药，其中取代基如本文所定义，这些化合物可用作治疗剂。
• FUSED RING HETEROARYL KINASE INHIBITORS
  申请人：Dar Arvin

  公开号：US20110275651A1

  公开（公告）日：2011-11-10

  Provided herein are fused ring heteroaryl compounds useful in a variety of methods, including reducing the activity of certain kinases and treating certain disease states.

  本文提供了融合环杂芳基化合物，可用于多种方法，包括降低某些激酶的活性和治疗某些疾病状态。
• METHODS OF INHIBITING IRE1
  申请人：Korennykh Alexei

  公开号：US20120322814A1

  公开（公告）日：2012-12-20

  Disclosed herein are, inter alia, methods for inhibiting Ire1 activity.

  本文披露了抑制Ire1活性的方法，其中包括：
• A Photocontrolled β-Hairpin Peptide
  作者：Shou-Liang Dong、Markus Löweneck、Tobias E. Schrader、Wolfgang J. Schreier、Wolfgang Zinth、Luis Moroder、Christian Renner

  DOI：10.1002/chem.200500986

  日期：2006.1.23

  Abstractβ‐Hairpins constitute the smallest β‐type structures in peptides and proteins. The development of highly stable, yet monomeric β‐hairpins based on the tryptophan zipper motif was therefore a remarkable success [A. G. Cochran, N. J. Skelton, M. A. Starovasnik, Proc. Natl. Acad. Sci USA 2001, 98, 5578–5583]. We have been able to design, synthesize and characterize a hairpin based on this motif which incorporates an azobenzene‐based photoswitch, that allows for time‐resolved folding studies of β‐structures with unprecedented time resolution. At room temperature the trans‐azo isomer exhibits a mostly disordered structure; however, light‐induced isomerization to the cis‐azo form leads to a predominantly extended and parallel conformation of the two peptide parts, which are linked by the novel photoswitch, [3‐(3‐aminomethyl)phenylazo]phenylacetic acid (AMPP). While in the original sequence the dipeptide Asn‐Gly forms a type I′ β‐turn which connects the two strands of the hairpin, this role is adopted by the AMPP chromophore in our photoresponsive β‐hairpin that can apparently act as a β I′‐turn mimetic. The β‐hairpin structure was determined and confirmed by NMR spectroscopy, but the folding process can be monitored by pronounced changes in the CD, IR and fluorescence spectra. Finally, incorporation of the structurally and functionally important β‐hairpin motif into proteins by chemical ligation might allow for the photocontrol of protein structures and/or functions.
• AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS
  申请人：Boehringer Ingelheim Pharmaceuticals Inc.

  公开号：EP1147104B1

  公开（公告）日：2012-03-14