phosphonic acid bis-(1,3-dimethyl-butyl ester)

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: phosphonic acid bis-(1,3-dimethyl-butyl ester)
• 英文别名: Phosphonsaeure-bis-(1,3-dimethyl-butylester)；Bis-(1.3-dimethyl-butyl)-phosphit；Bis(4-methylpentan-2-yl) hydrogen phosphite；bis(4-methylpentan-2-yl) hydrogen phosphite
• 化学式: C₁₂H₂₇O₃P
• 分子量: 250.318
• InChiKey: MLANDNZBZLTNJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  phosphonic acid bis-(1,3-dimethyl-butyl ester) 在 四氯化碳 、 N-氯代丁二酰亚胺 作用下， 生成 2-(氟-(4-甲基戊烷-2-基氧基)磷酰)氧基-4-甲基戊烷
  参考文献：
  名称：

  Goldwhite; Saunders, Journal of the Chemical Society, 1955, p. 2040

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基-2-戊醇 在 四氯化碳 、 三氯化磷 作用下， 生成 phosphonic acid bis-(1,3-dimethyl-butyl ester)
  参考文献：
  名称：

  Cook; McCombie; Saunders, Journal of the Chemical Society, 1945, p. 875

  摘要：

  DOI：

文献信息

• Cook; McCombie; Saunders, Journal of the Chemical Society, 1945, p. 874
  作者：Cook、McCombie、Saunders

  DOI：——

  日期：——
• CHAIN-EXTENDED POLYDIMETHYLSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF
  申请人：Alcon Inc.

  公开号：EP3526278B1

  公开（公告）日：2020-12-30
• METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES
  申请人：Alcon Inc.

  公开号：EP3774310B1

  公开（公告）日：2022-07-06
• [EN] METHOD FOR PRODUCING PHOTOCHROMIC CONTACT LENSES<br/>[FR] PROCÉDÉ DE PRODUCTION DE LENTILLES DE CONTACT PHOTOCHROMIQUES
  申请人：ALCON INC

  公开号：WO2020230016A1

  公开（公告）日：2020-11-19

  The invention provides a method for producing photochromic silicone hydrogel (SiHy) contact lenses based on thermal cast-molding technology in a relatively efficient and consistent manner. The method is characterized by selecting a high radical-reactive hydrophilic acrylic monomer while eliminating any low radical-reactive hydrophilic N-vinyl amide monomer in a lens formulation (polymerizable composition), by selecting a weight ratio of low-radical-reactive hydrophilic N-vinyl amide monomer to a high radical- reactive hydrophilic acrylic monomer in a lens formulation if the low radical-reactive hydrophilic N- vinyl amide monomer is needed, and/or by using a relatively high temperature thermal initiator in a lens formulation, to control the lens properties (e.g., water content, elastic modulus, etc.) and lens processability (capability of dry-delensing from molds) of thermally cast-molded SiHy contact lenses while minimizing loss in photochromic ability of resultant SiHy contact lenses.
• [EN] METHOD FOR MAKING OPAQUE COLORED SILICONE HYDROGEL CONTACT LENSES<br/>[FR] PROCÉDÉ DE FABRICATION DE LENTILLES DE CONTACT EN HYDROGEL DE SILICONE COLORÉES OPAQUES
  申请人：ALCON INC

  公开号：WO2020240440A1

  公开（公告）日：2020-12-03

  The invention provides a thermal cast-molding method for producing colored silicone hydrogel contact lenses. The method of the invention comprises: (1) forming, on a molding surface of a mold, a transferable colored polymeric composite film which comprises or consists essentially of a first polymeric film, a second polymeric film and a cured colored image encapsulated therewithin; (2) dispensing a silicone hydrogel lens formulation into the lens-forming cavity of the mold; and (4) thermally curing the third polymerizable composition within the lens-forming cavity for at least about 40 minutes to form the colored silicone hydrogel contact lens, whereby the transferrable, colored, and polymeric composite film detaches from the first or second molding surface and becomes integral with the body of the silicone hydrogel contact lens.