4-(4-(R)-1-methylheptyloxyphenyl)phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-(R)-1-methylheptyloxyphenyl)phenol
• 英文别名: (R)-4'-(1-methylheptyloxy)-4-hydroxybiphenyl；4-[4-[(2R)-octan-2-yl]oxyphenyl]phenol
• 化学式: C₂₀H₂₆O₂
• 分子量: 298.425
• InChiKey: NVWSKZDCJFORNE-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(4-(R)-1-methylheptyloxyphenyl)phenol 在 三氟甲磺酸酐 作用下， 以 吡啶 为溶剂， 反应 24.0h， 以97.3%的产率得到(R)-4'-(1-methylheptyloxy)biphenyl-4-yl trifluoromethanesulfonate
  参考文献：
  名称：

  Polymerizable compound, polymerizable resin composition, cured polymer and liquid crystal display device

  摘要：

  这项发明的可聚合化合物由通式（I）表示：其中R为H，R′，R′O，R′COO或R′OCO，R′为具有1至约15个碳原子的直链或支链烷基或烯基基团，A1和A2分别为环己烷环或苯环，可能包括下面通式（II）表示的取代基；X为H或CH3；Y1、Y2、Y3和Y4独立地为H、F、Cl、CH3、CH3O、CF3或CF3O，其中至少两个Y1、Y2、Y3和Y4为H，如果A1和A2均为环己烷环，则至少有一个Y1、Y2、Y3和Y4不为H：其中Y5、Y6、Y7和Y8独立地为H、F、Cl、CH3、CH3O、CF3或CF3O，至少两个Y5、Y6、Y7和Y8为H。

  公开号：

  US06388146B1
• 作为产物：
  描述：

  (S)-(+)-2-辛醇 、 4,4'-二羟基联苯 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以47%的产率得到4-(4-(R)-1-methylheptyloxyphenyl)phenol
  参考文献：
  名称：

  Design of a Dynamic Polymer Interface for Chiral Discrimination

  摘要：

  Enantioselective wetting of a chiral polymer film was demonstrated. The contact angle of chiral liquids on the film was strongly dependent on their chirality although their physical properties including surface tension were identical. Such wetting behavior resulted from the enantioselective surface reorganization involving local conformational change of the polymer chains at the liquid interface. The concept of "dynamic interface for chiral discrimination" has possible potential for the development of materials capable of chiral sensing, optical resolution, and asymmetric synthesis.

  DOI：

  10.1021/ja404701s

文献信息

• Stabilization of the blue phases of simple rodlike monoester compounds by addition of their achiral homologues
  作者：Keiki Kishikawa、Hiroyuki Itoh、Seiji Akiyama、Takahiro Kobayashi、Shigeo Kohmoto

  DOI：10.1039/c2jm16359d

  日期：——

  As novel rodlike liquid crystalline ester compounds exhibiting blue phases (BPs), chiral 4-(4′-alkoxyphenyl)phenyl 4-(4′-alkoxyphenyl)benzoate derivatives (R–C6H4–C6H4–OCO–C6H4–C6H4–R′), 1 (R = R′ = (R)-1-methylheptyloxy, BP range: 1.6 K on heating), 2 (R = (R)-1-methylheptyloxy, R′ = n-octyloxy, BP range: 0.8 K on heating), 4 (R = (R)-1-methylheptyloxy, R′ = H, BP range: 1.0 K on heating), were synthesized and their phase behaviors were investigated. Further, the BP of 1 was stabilized by addition of its achiral homologue ester compound 3 (R = R′ = n-octyloxy). In the range of the composite ratio of 1 : 3 from 10 : 0 to 0 : 10, the BP temperature range became wider with increase of the content of 3 in the mixture. At the ratio of 6 : 4, the BP indicated the widest temperature range in the mixing experiment (5.0 K on heating and 6.0 K on cooling).

  1 (R = R′ = (R)-1-methylheptyloxy, BP range: 1.6 K on heating), 2 (R = (R)-1-methylheptyloxy, R′ = n-octyloxy, BP range：加热时的 BP 范围：0.8 K），4（R = (R)-1-甲基庚氧基，R′ = H，加热时的 BP 范围：1.0 K合成并研究了它们的相行为。此外，通过添加其非手性同族酯化合物 3（R = R′ = 正辛基氧基），稳定了 1 的 BP。在 1 ：3 的复合比例范围内，从 10 ：0 到 0 ：10 的范围内，随着混合物中 3 的含量增加，BP 温度范围变宽。当比例为 6 ：在混合实验中，BP 的温度范围最广（加热时为 5.0 K，冷却时为 6.0 K）。
• TAKEHXARA, SADAO;SEDZI, TADAO;FUDZISAVA, JOROSI;OGAVA, XIROSI;OSAVA, MASA+
  作者：TAKEHXARA, SADAO、SEDZI, TADAO、FUDZISAVA, JOROSI、OGAVA, XIROSI、OSAVA, MASA+

  DOI：——

  日期：——
• US6388146B1
  申请人：——

  公开号：US6388146B1

  公开（公告）日：2002-05-14
• Polymerizable compound, polymerizable resin composition, cured polymer and liquid crystal display device
  申请人：Sharp Kabushiki Kaisha

  公开号：US06388146B1

  公开（公告）日：2002-05-14

  The polymerizable compound of this invention is represented by general formula (I): where R is H, R′, R′O, R′COO, or R′OCO, R′ is a linear or branched alkyl group or alkenyl group having 1 to about 15 carbon atoms, A1 and A2 are independently a cyclohexane ring or a benzene ring which may include a substituent represented by formula (II) below; X is H or CH3; and Y1, Y2, Y3, and Y4 are independently H, F, Cl, CH3, CH3O, CF3, or CF3O wherein at least two of Y1, Y2, Y3, and Y4 are H and, if both A1 and A2 are cyclohexane rings, at least one of Y1, Y2, Y3, and Y4 is not H: where Y5, Y6, Y7, and Y8 are independently H, F, Cl, CH3, CH3O, CF3, or CF3O, at least two of Y5, Y6, Y7, and Y8 are H.

  这项发明的可聚合化合物由通式（I）表示：其中R为H，R′，R′O，R′COO或R′OCO，R′为具有1至约15个碳原子的直链或支链烷基或烯基基团，A1和A2分别为环己烷环或苯环，可能包括下面通式（II）表示的取代基；X为H或CH3；Y1、Y2、Y3和Y4独立地为H、F、Cl、CH3、CH3O、CF3或CF3O，其中至少两个Y1、Y2、Y3和Y4为H，如果A1和A2均为环己烷环，则至少有一个Y1、Y2、Y3和Y4不为H：其中Y5、Y6、Y7和Y8独立地为H、F、Cl、CH3、CH3O、CF3或CF3O，至少两个Y5、Y6、Y7和Y8为H。
• Design of a Dynamic Polymer Interface for Chiral Discrimination
  作者：Atsuomi Shundo、Koichiro Hori、Takuya Ikeda、Nobuo Kimizuka、Keiji Tanaka

  DOI：10.1021/ja404701s

  日期：2013.7.17

  Enantioselective wetting of a chiral polymer film was demonstrated. The contact angle of chiral liquids on the film was strongly dependent on their chirality although their physical properties including surface tension were identical. Such wetting behavior resulted from the enantioselective surface reorganization involving local conformational change of the polymer chains at the liquid interface. The concept of "dynamic interface for chiral discrimination" has possible potential for the development of materials capable of chiral sensing, optical resolution, and asymmetric synthesis.