2-hydroxyterephthalate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxyterephthalate
• 英文别名: 4-Carboxy-3-oxidobenzoate
• 化学式: C₈H₄O₅
• 分子量: 180.117
• InChiKey: CDOWNLMZVKJRSC-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  magnesium(II) nitrate hexahydrate 、 2,5-二羟基对苯二甲酸 、 2-hydroxyterephthalate 以 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 生成
  参考文献：
  名称：

  Generation of Defect‐Modulated Metal–Organic Frameworks by Fragmented‐Linker Co‐Assembly of CPO‐27(M) Frameworks

  摘要：

  AbstractThe generation of defect‐modulated metal–organic frameworks (MOFs) by the successful stepwise doping of 2‐hydroxyterephthalate (BDC‐OH) into frameworks of the CPO‐27‐M type is discussed. The influence of MgII, CoII, and NiII ions on the product formation has been investigated by powder XRD (PXRD), IR spectroscopy, and thermal analysis. To establish the successful incorporation of the fragmented linker molecule, 1H NMR spectra were recorded after the digestion of the MOFs in DCl/[D6]dimethyl sulfoxide. After the incorporation of BDC‐OH, microporous structures were generated with reasonable porosity. The morphologies of the reaction products were checked by SEM measurements, and no significant changes to the morphologies were observed after the fragmented‐linker doping.

  DOI：

  10.1002/ejic.201403110
• 作为产物：
  描述：

  对苯二甲酸酯(2-) 在 3-吗啉丙磺酸 、 水 、 C₁₈H₃₀CuN₈O₄*H⁽¹⁺⁾ 、 维生素 C 作用下， 生成 2-hydroxyterephthalate
  参考文献：
  名称：

  Cu(II) ATCUN 金属肽中 N-杂芳族 N-末端对其生物相关氧化还原活性的影响

  摘要：

  已经研究了具有 ATCUN 肽配体的Cu( II ) 复合物的 ROS（活性氧）生成和氧化 DNA 降解能力。然而，大多数 ATCUN 复合物如 Cu-GGH (Gly-Gly-His) 的生物活性都很低。通过掺入 N-杂芳烃来调整氧化还原化学可恢复 ROS 的产生，从而实现有效的 DNA 切割。

  DOI：

  10.1039/d2dt02044k

文献信息

• Photochemical efficiency of Fe(III)-EDDS complex: OH radical production and 17β-estradiol degradation
  作者：Jing Li、Gilles Mailhot、Feng Wu、Nansheng Deng

  DOI：10.1016/j.jphotochem.2010.03.001

  日期：2010.4

  In this work, the photochemical impact of Fe(III)-EDDS complex on the quantum yield of OH formation and on the degradation of 17β-estradiol (E2) was investigated. The quantum yield of OH formation by photolysis of Fe(III)-EDDS increased with increasing pH in the range of 3.0–9.0. The effect of Fe(III)-EDDS concentration, irradiation wavelength and oxygen on the quantum yield of OH formation was also

  在这项工作中，研究了Fe（III）-EDDS络合物对OH形成的量子产率和17β-雌二醇（E2）降解的光化学影响。通过Fe（III）-EDDS的光解形成OH的量子产率随pH值的增加在3.0-9.0范围内增加。还研究了Fe（III）-EDDS浓度，辐照波长和氧气对OH形成量子产率的影响。E2的降解受Fe（III）-EDDS浓度，溶液pH，氧气和Fe（III）浓度的影响。这项工作表明，Fe（III）-EDDS是一种光敏铁物种，尤其是在较高的pH值下，并且可以在自然环境中的有机化合物转化中发挥重要作用。
• Hydroxyterephthalate as a Fluorescent Probe for Hydroxyl Radicals: Application to Hair Melanin
  作者：Xinhua Qu、Louis J. Kirschenbaum、Edward T. Borish

  DOI：10.1562/0031-8655(2000)0710307haafpf2.0.co2

  日期：2000.3
• Generation of Defect‐Modulated Metal–Organic Frameworks by Fragmented‐Linker Co‐Assembly of CPO‐27(M) Frameworks
  作者：Nadia E. A. El‐Gamel

  DOI：10.1002/ejic.201403110

  日期：2015.3

  AbstractThe generation of defect‐modulated metal–organic frameworks (MOFs) by the successful stepwise doping of 2‐hydroxyterephthalate (BDC‐OH) into frameworks of the CPO‐27‐M type is discussed. The influence of MgII, CoII, and NiII ions on the product formation has been investigated by powder XRD (PXRD), IR spectroscopy, and thermal analysis. To establish the successful incorporation of the fragmented linker molecule, 1H NMR spectra were recorded after the digestion of the MOFs in DCl/[D6]dimethyl sulfoxide. After the incorporation of BDC‐OH, microporous structures were generated with reasonable porosity. The morphologies of the reaction products were checked by SEM measurements, and no significant changes to the morphologies were observed after the fragmented‐linker doping.
• Impact of N-heteroaromatic N-termini in Cu(<scp>ii</scp>) ATCUN metallopeptides on their biorelevant redox activity
  作者：Jannis Barrera、Haleh H. Haeri、Julian Heinrich、Matthias Stein、Dariush Hinderberger、Nora Kulak

  DOI：10.1039/d2dt02044k

  日期：——

  Cu(II) complexes with ATCUN peptide ligands have been investigated for their ROS (reactive oxygen species) generation and oxidative DNA degradation abilities. The biological activity of most ATCUN complexes such as Cu-GGH (Gly-Gly-His) is, however, low. Tuning the redox chemistry by incorporation of N-heteroaromatics reinstates ROS production which leads to efficient DNA cleavage.

  已经研究了具有 ATCUN 肽配体的Cu( II ) 复合物的 ROS（活性氧）生成和氧化 DNA 降解能力。然而，大多数 ATCUN 复合物如 Cu-GGH (Gly-Gly-His) 的生物活性都很低。通过掺入 N-杂芳烃来调整氧化还原化学可恢复 ROS 的产生，从而实现有效的 DNA 切割。