N-benzoyl-3-<(benzoyloxy)methyl>piperidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzoyl-3-<(benzoyloxy)methyl>piperidine
• 英文别名: (1-Benzoylpiperidin-3-yl)methyl benzoate
• 化学式: C₂₀H₂₁NO₃
• 分子量: 323.392
• InChiKey: HEZKTHOJWXYBQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-哌啶甲醇 、 苯甲酰氯 在 二正丁基氧化锡 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 0.15h， 以11%的产率得到N-benzoyl-3-<(benzoyloxy)methyl>piperidine
  参考文献：
  名称：

  Microwave-Promoted Transformations:  Fast and Chemoselective N-Acylation of Amino Alcohols Using Catalytic Amounts of Dibutyltin Oxide. Influence of the Power Output and the Nature of the Acylating Agent on the Selectivity

  摘要：

  The influence of the nature of the acylating agent and the power output on the chemoselectivity of the microwave-mediated acylation of 1,2- and 1,3-amino alcohols catalyzed by dibutyltin oxide has been studied. The method constitutes an efficient procedure for the selective N-acylation of amino alcohols.

  DOI：

  10.1021/jo9605511

文献信息

• Novel piperidine .sigma. receptor ligands as potential antipsychotic drugs
  作者：Paul J. Gilligan、Gary A. Cain、Thomas E. Christos、Leonard Cook、Spencer Drummond、Alexander L. Johnson、Ahmed A. Kergaye、John F. McElroy、Kenneth W. Rohrbach

  DOI：10.1021/jm00101a012

  日期：1992.11

  Sigma receptor ligands represent a new class of potential antipsychotic drugs. This paper presents the structure-activity relationships leading to novel disubstituted piperidine sigma ligands, which have little or no affinity for dopamine D2 receptors. Selectivity for sigma sites over dopamine D2 or serotonin 5-HT2 receptors appears to be governed by the chemical nature of the piperidine nitrogen substituent, its distance from the basic nitrogen, and its orientation relative to the other piperidine substituent. Several of these compounds have good oral potency in some animal models used to evaluate potential antipsychotic drugs. The N-cyclopropylmethyl ketones and ethers (e.g. 6i (DuP 734), 6q, 18a, and 18n) have the best in vivo potency. Compounds 6i (DuP 734) and 6q did not cause catalepsy in the rat, even at very high doses. On the basis of the pharmacology profiles of these sigma ligands, we propose these compounds may be effective antipsychotic drugs, which do not induce extrapyramidal side effects or tardive dyskinesia.
• Microwave-Promoted Transformations:  Fast and Chemoselective N-Acylation of Amino Alcohols Using Catalytic Amounts of Dibutyltin Oxide. Influence of the Power Output and the Nature of the Acylating Agent on the Selectivity
  作者：Anabel Morcuende、Marta Ors、Serafín Valverde、Bernardo Herradón

  DOI：10.1021/jo9605511

  日期：1996.1.1

  The influence of the nature of the acylating agent and the power output on the chemoselectivity of the microwave-mediated acylation of 1,2- and 1,3-amino alcohols catalyzed by dibutyltin oxide has been studied. The method constitutes an efficient procedure for the selective N-acylation of amino alcohols.