6-formylpyridine-2-carbothionic acid-S-(2-methoxyphenyl) ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-formylpyridine-2-carbothionic acid-S-(2-methoxyphenyl) ester
• 英文别名: 6-Formyl-pyridine-2-carbothioic acid S-(2-methoxy-phenyl) ester；S-(2-methoxyphenyl) 6-formylpyridine-2-carbothioate
• 化学式: C₁₄H₁₁NO₃S
• 分子量: 273.312
• InChiKey: QCFRPTDVCMUBNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  81.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吡啶-2.6-二羧酸二甲酯 在 manganese(IV) oxide 、 氢氧化钾 、 sodium tetrahydroborate 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 丙酮 为溶剂， 反应 4.0h， 生成 6-formylpyridine-2-carbothionic acid-S-(2-methoxyphenyl) ester
  参考文献：
  名称：

  Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities

  摘要：

  Twenty-one pyridine-2-carboxylate derivates were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol. thiophenol. and aniline. substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) shoved the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)01041-7

文献信息

• Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities
  作者：Sang-sup Jew、Boon-saeng Park、Doo-yeon Lim、Myoung Goo Kim、In Kwon Chung、Joo Hee Kim、Chung Il Hong、Joon-Kyum Kim、Hong-Jun Park、Jun-Hee Lee、Hyeung-geun Park

  DOI：10.1016/s0960-894x(02)01041-7

  日期：2003.2

  Twenty-one pyridine-2-carboxylate derivates were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol. thiophenol. and aniline. substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) shoved the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity. (C) 2003 Elsevier Science Ltd. All rights reserved.