2,2-dichloro-3,3-dimethyloxirane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: 2,2-dichloro-3,3-dimethyloxirane
• 化学式: C₄H₆Cl₂O
• 分子量: 140.997
• InChiKey: ZOPSFRAJVKJCQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,2-dichloro-3,3-dimethyloxirane 、 2-氨基-N-苄基苯甲酰胺 反应 3.0h， 以80%的产率得到4-benzyl-1,2-dihydro-2,2-dimethyl-4H-benzo[e][1,4]diazepine-3,5-dione
  参考文献：
  名称：

  Synthesis of Novel 1,4-Benzodiazepine-3,5-dione Derivatives: Reaction of 2-Aminobenzamides under Bargellini Reaction Conditions

  摘要：

  In this paper, we report on a user-friendly synthesis of 1,4-benzodiazepine- 3,5- dione derivatives via Bargellini-type reaction. The corresponding products were obtained using various 2-aminobenzamides under Bargellini reaction conditions, in good yields without unfavorable side reaction.

  DOI：

  10.1055/s-0032-1317297
• 作为产物：
  描述：

  sodium trichloromethyl 、 丙酮 生成 2,2-dichloro-3,3-dimethyloxirane
  参考文献：
  名称：

  [EN] TOUGHENED VINYL ESTER RESINS
  [FR] RESINES DE VINYLESTER TREMPEES

  摘要：

  一种乙烯基酯树脂是由不饱和酸与由二硫或三硫引发剂制成的环氧末端聚合物反应而得的，可选地还包括环氧树脂。这种乙烯基酯树脂可以与相容的增韧剂和稀释剂混合，以提供一个时间稳定的体系，随后交联以提供具有改善增韧性能的组合物。

  公开号：

  WO2005080326A1

文献信息

• [EN] PROCESS FOR PREPARATION OF ELAFIBRANOR<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ELAFIBRANOR
  申请人：GLENMARK PHARMACEUTICALS LTD GLENMARK LIFE SCIENCES LTD

  公开号：WO2020079541A1

  公开（公告）日：2020-04-23

  The present invention provides a process for elafibranor, the process comprising reacting compound of formula II or the compound of formula III with a compound of formula IV. The present invention also involve purification of elafibranor by reacting elafibranor with benzyl amine to form compound of formula IX and treating compound of formula IX with acid to form elafibranor.

  本发明提供了一种Elafibranor的制备过程，其包括将式II化合物或式III化合物与式IV化合物反应。本发明还涉及通过将Elafibranor与苄基胺反应形成式IX化合物，并用酸处理式IX化合物形成Elafibranor的纯化方法。
• Poly (3-(Substituted)-3(Hydroxymethyl) oxetane) and method of preparing same
  申请人：ARIZONA BOARD OF REGENTS

  公开号：EP0345073A1

  公开（公告）日：1989-12-06

  Poly[3,3-bis(hydroxymethyloxetane] ("PBHMO") is prepared in high molecular weight (ninh to 5.2) by polymerizing the trimethylsilylether of 3,3-bis (hydroxymethyl)oxetane with i-Bu₃Al-0.7 H₂O cationic catalyst at low temperature, followed by hydrolysis. PBHMO is crystalline, high melting (about 314oC), highly insoluble and useful in the production of films and fibers. Poly[3-methyl-3- (hydroxymethyl)oxetane] ("PMHMO") and poly [3-ethyl-3-(hydroxymethyl)oxetane] ("PEHMO") are also prepared in high molecular weight (ninh up to 3.8) by the same procedures. Copolymers of BHMO, MHMO, and EHMO with each other or containing up to about 50% of other oxetanes, oxiranes and tetrahydrofurans; derivatives and alloys from these polymers and copolymers; and methods of preparing the polymers, copolymers, alloys and derivatives into useful films, fibers and articles is described.

  聚[3,3-双（羟甲基）氧杂环丁烷]（"PBHMO"）是通过 i-Bu₃Al-0.7 H₂O 阳离子催化剂在低温下聚合 3,3-双（羟甲基）氧杂环丁烷的三甲基硅醚，然后进行水解，制备出高分子量（ninh 至 5.2）的聚[3,3-双（羟甲基）氧杂环丁烷]。PBHMO 呈结晶状，熔点高（约 314 摄氏度），极不溶解，可用于生产薄膜和纤维。聚[3-甲基-3-（羟甲基）氧杂环丁烷]（"PMHMO"）和聚[3-乙基-3-（羟甲基）氧杂环丁烷]（"PEHMO"）也可通过相同的程序制备出高分子量（ninh 高达 3.8）的聚[3-甲基-3-（羟甲基）氧杂环丁烷]（"PMHMO"）。此外，还介绍了 BHMO、MHMO 和 EHMO 与其他氧杂环丁烷、环氧乙烷和四氢呋喃的共聚物，以及这些聚合物和共聚物的衍生物和合金，以及将聚合物、共聚物、合金和衍生物制备成有用薄膜、纤维和物品的方法。
• High molecular weight polymers and copolymers of 3-hydroxyoxetane and derivatives thereof.
  申请人：ARIZONA BOARD OF REGENTS

  公开号：EP0345074A1

  公开（公告）日：1989-12-06

  High molecular weight (Mw > 25,000, preferably > 50,000; ninh up to 3) linear atactic poly (3-hydroxyoxetane) (PHO) are made by polymerizing the trimethylsilyl ether of 3-hydroxyoxetane with a coordination catalyst, or preferably with a cationic catalyst such as i-Bu₃Al-0.7 H₂O, followed by hydrolysis. The new polymer is atactic, highly crystalline, has a melting point of 155oC, is devoid of measurable end groups, has a two-peak ¹³C-NMR, and can be readily compression molded at 200oC to a film which can be drawn at room temperature to give enhanced strength. Isotactic high molecular weight PHO(mp = 223oC; ΔHf = 25.6 cal/g) and branched high molecular weight PHO are also prepared.

  高分子量（Mw > 25,000，最好 > 50,000；ninh 高达 3）线性无规聚（3-羟基氧杂环丁烷）（PHO）是由 3-羟基氧杂环丁烷的三甲基硅基醚与配位催化剂，或最好与阳离子催化剂（如 i-Bu₃Al-0.7 H₂O）聚合，然后水解制成的。这种新型聚合物为无规聚合物，结晶度高，熔点为 155oC，不含可测量的端基，具有双峰 ¹³C-NMR，可在 200oC 温度下压缩成型为薄膜，在室温下拉伸可增强强度。 此外，还制备了等轴高分子量 PHO（mp = 223oC；ΔHf = 25.6 cal/g）和支化高分子量 PHO。
• Polymerization catalysts of oxirane compounds and process for preparing polymers of oxirane compounds using the catalysts
  申请人：DAISO CO., LTD.

  公开号：US20020013388A1

  公开（公告）日：2002-01-31

  Polymerization catalysts of oxirane compounds are catalysts which are suitable to carry out suspension precipitation polymerization of the oxirane compounds in an organic solvent which cannot dissolve the polymers and comprise a reaction product of (A) an alkylaluminum compound, (B) an oxoacid compound of phosphorus having at least one OH group in its molecule and (C) a nitrogen-containing cyclic compound having pKa of 6 to 8. A process for preparing the polymers of the oxirane compounds is a process wherein the monomeric oxirane compounds are subjected to the suspension precipitation polymerization in the organic solvent which cannot dissolve the polymers in the presence of the catalysts to prepare the polymers of the oxirane compounds.

  环氧乙烷化合物聚合催化剂是适用于在不能溶解聚合物的有机溶剂中进行环氧乙烷化合物悬浮沉淀聚合反应的催化剂，由以下物质的反应产物组成：(A)烷基铝化合物；(B)分子中至少有一个OH基团的磷的环氧化合物；(C)pKa为6至8的含氮环状化合物。制备环氧乙烷化合物聚合物的工艺是在催化剂存在下，将环氧乙烷单体化合物在不能溶解聚合物的有机溶剂中进行悬浮沉淀聚合，制备环氧乙烷化合物聚合物的工艺。
• Preservative-containing virus formulations
  申请人：Evans K. Robert

  公开号：US20070148765A1

  公开（公告）日：2007-06-28

  The preservation of live viral vaccines is disclosed. These liquid formulations comprise a live virus and a preservative, namely chlorobutanol. The preserved, live virus formulations of the present invention are (1) suitable for a vaccine or gene therapy product with a multi-dose image; (2) compatible with parenteral administration; and (3) are stable for extended periods of time with negligible loss of activity.