4-(2,4-dihydroxybenzoyl)isophthalic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2,4-dihydroxybenzoyl)isophthalic acid
• 英文别名: 4-(2,4-Dihydroxybenzoyl)benzene-1,3-dicarboxylic acid
• 化学式: C₁₅H₁₀O₇
• 分子量: 302.24
• InChiKey: NJLVWNHNFAVUAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-(2,4-dihydroxybenzoyl)isophthalic acid 在 甲烷磺酸 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 36.0h， 生成 N-(6-(3-(3-chlorophenethyl)-5-cyclopentyl-2,4,6-trioxocyclohexyl)hexyl)-3’,6’-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9’-xanthene]-5-carboxamide
  参考文献：
  名称：

  Synthesis of a fluorescent chemical probe for imaging of L-type voltage-gated calcium channels

  摘要：

  Herein, we report the synthesis of a chemical probe for real-time visualization of L-type voltage-gated calcium channels (LTCCs) using fluorescence microscopy. The probe, FluoBar2, is based on a barbiturate ligand selective for LTCCs. FluoBar2 contains the organic fluorophore 5-carboxyfluorescein and was synthesized in seven total steps with a 22% overall yield.

  DOI：

  10.1139/cjc-2023-0149
• 作为产物：
  描述：

  3',6'-bis(2,2-dimethyl-1-oxopropoxy)-3-oxo-spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid 在 sodium hydroxide 作用下， 生成 4-(2,4-dihydroxybenzoyl)isophthalic acid
  参考文献：
  名称：

  CN116354980

  摘要：

  公开号：

文献信息

• SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
  申请人：Bellott M. Emile

  公开号：US20070110672A1

  公开（公告）日：2007-05-17

  Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

  用于体内葡萄糖生物传感器的Small Molecule Metabolite Reporters (SMMRs)、传感器组合物及其使用方法被描述。SMMRs包括含有硼酸的小分子，基于黄烷、香豆素、卡波罗司坦和菲内烯，用于监测体内的葡萄糖，优选在皮肤上。
• [EN] METHOD FOR THE PREPARATION OF INTERMEDIATES FOR CARBOXY-FLUORESCEINS AND NOVEL CARBOXY-FLUORESCEIN<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION D'INTERMÉDIAIRES POUR DES CARBOXY-FLUORESCÉINES ET NOUVELLE CARBOXY-FLUORESCÉINE
  申请人：UNIV DANMARKS TEKNISKE

  公开号：WO2015169854A1

  公开（公告）日：2015-11-12

  The invention provides a method for the preparation of regioisomerically pure intermediates which are useful for the preparation of carboxy-fluorescein-type compounds. Such compounds have broad applications within bio-conjugation and/or fluorescent imaging.

  该发明提供了一种制备区位异构纯中间体的方法，这些中间体对于制备羧基荧光素类化合物非常有用。这些化合物在生物共轭和/或荧光成像中具有广泛的应用。
• Facile Large-Scale Synthesis of 5- and 6-Carboxyfluoresceins: Application for the Preparation of New Fluorescent Dyes
  作者：Peter Hammershøj、E. K. Pramod Kumar、Pernille Harris、Thomas L. Andresen、Mads H. Clausen

  DOI：10.1002/ejoc.201501013

  日期：2015.11

  fluorescein dyes have been prepared from a common precursor through a very simple synthetic procedure, giving access to important precursors for fluorescent probes. The method has proven an efficient access to regioisomerically pure 5- and 6-carboxyfluoresceins on a large scale, in good yields, and with high regioisomeric purity. Furthermore, we have applied the method to the development of a new type of

  已经通过非常简单的合成程序从常见的前体制备了一系列荧光素染料，从而可以获得荧光探针的重要前体。该方法已证明可以有效地大规模、高产率和高区域异构纯度获得区域异构纯的 5- 和 6- 羧基荧光素。此外，我们已将该方法应用于新型 5-羧基荧光素混合荧光素衍生物的开发。我们已经通过在氟玉家族中合成一种新型双发色团来证明该程序的范围。
• Convenient one-step synthesis of 5-carboxy-seminaphthofluoresceins
  作者：Peter Hammershøj、Erling Thyrhaug、Pernille Harris、Pramod K. Ek、Thomas L. Andresen、Mads H. Clausen

  DOI：10.1016/j.tetlet.2017.03.028

  日期：2017.4

  The one-step synthesis and characterization of a series of regioisomerically pure 5-carboxy-seminaphthofluoresceins (5-carboxy-SNAFLs) is reported. The optical properties were determined in aqueous buffer at around biological pH, and highly pH sensitive, large Stokes-shift fluorophores with emission in the deep-red to near-infrared region were identified.

  报告了一系列区域异构纯的5-羧基-seminaphthofluoresceins（5-羧基-SNAFLs）的一步合成和表征。在生物pH值附近的水性缓冲液中测定光学性质，并鉴定出具有高pH敏感性的大型Stokes位移荧光团，其发射光在深红色至近红外区域。
• Protective film forming agent and method for producing semiconductor chip
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US11407063B2

  公开（公告）日：2022-08-09

  A protective film forming agent for dicing of semiconductor wafers for forming a protective film on the surface of the semiconductor wafers and capable of forming a protective film of high absorbance index, and a production method of semiconductor chips using the protective film forming agent. In a protective film forming agent containing a water-soluble resin, light absorber and solvent, a compound having a specific structure is used as the light absorber. The content of the light absorber in the protective film forming agent is 0.1% by mass or more and 10% by mass or less.

  一种用于半导体晶片切割的保护膜形成剂，可在半导体晶片表面形成保护膜，并能形成高吸收指数的保护膜，以及一种使用该保护膜形成剂的半导体芯片生产方法。在含有水溶性树脂、光吸收剂和溶剂的保护膜形成剂中，使用了具有特定结构的化合物作为光吸收剂。光吸收剂在保护膜成型剂中的含量为 0.1%（以质量计）以上，10%（以质量计）以下。