ethyl 2-[(t-butoxycarbonyl)amino]undecanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 2-[(t-butoxycarbonyl)amino]undecanoate
• 英文别名: Ethyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]undecanoate
• 化学式: C₁₈H₃₅NO₄
• 分子量: 329.48
• InChiKey: SNCCJAFWFHCOJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  23
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-BOC-甘氨酸乙酯 在 bis(acetylacetonate)nickel(II) 4-氟苯乙烯 、 sodium iodide 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 N-甲基吡咯烷酮 、 正己烷 、 丙酮 为溶剂， 反应 21.0h， 生成 ethyl 2-[(t-butoxycarbonyl)amino]undecanoate
  参考文献：
  名称：

  Nickel-Catalyzed Cross-Coupling between Functionalized Primary or Secondary Alkylzinc Halides and Primary Alkyl Halides

  摘要：

  In the presence of Bu4NI (3 equiv) and 4-fluorostyrene (20 mol %), unreactive primary and secondary alkylzinc iodides undergo nickel-catalyzed cross-couplings with various primary alkyl iodides or bromides. More reactive secondary dialkylzincs and the mixed zinc organometallics RZnTMSM undergo the cross-coupling reaction in the absence of Bu4NI. The bicyclic secondary diorganozinc 6 prepared via boron-zinc exchange reacts with high retention of configuration. Free NH-groups are tolerated in the cross-coupling allowing the synthesis of aminated products.

  DOI：

  10.1021/jo0105787

文献信息

• Nickel-Catalyzed Cross-Coupling between Functionalized Primary or Secondary Alkylzinc Halides and Primary Alkyl Halides
  作者：Anne Eeg Jensen、Paul Knochel

  DOI：10.1021/jo0105787

  日期：2002.1.1

  In the presence of Bu4NI (3 equiv) and 4-fluorostyrene (20 mol %), unreactive primary and secondary alkylzinc iodides undergo nickel-catalyzed cross-couplings with various primary alkyl iodides or bromides. More reactive secondary dialkylzincs and the mixed zinc organometallics RZnTMSM undergo the cross-coupling reaction in the absence of Bu4NI. The bicyclic secondary diorganozinc 6 prepared via boron-zinc exchange reacts with high retention of configuration. Free NH-groups are tolerated in the cross-coupling allowing the synthesis of aminated products.