8-(thioacetyl)-octanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8-(thioacetyl)-octanoic acid
• 英文别名: 9-Sulfanylidenedecanoic acid；9-sulfanylidenedecanoic acid
• 化学式: C₁₀H₁₈O₂S
• 分子量: 202.318
• InChiKey: QRNHLMNBMPPZST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  69.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  五氟苯酚 、 8-(thioacetyl)-octanoic acid 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以82%的产率得到8-acetylthio pentafluorophenyl octanoate
  参考文献：
  名称：

  Efficient Phosphodiester Cleaving Nanozymes Resulting from Multivalency and Local Medium Polarity Control

  摘要：

  The self-organization of Zn(II) complexes on the surface of 1.6-nm diameter gold nanoparticles (nanozymes) allows the spontaneous formation of multiple bimetallic catalytic sites capable to promote the cleavage of a RNA model substrate. We show that by tuning the structure of the nanoparticle-coating monolayer, it is possible to decrease the polarity of the reaction site, and this in turn generates remarkable increments of the cleavage efficiency.

  DOI：

  10.1021/ja411969e
• 作为产物：
  描述：

  8-溴辛酸 、 potassium thioacetate 以 丙酮 为溶剂， 反应 48.0h， 以87%的产率得到8-(thioacetyl)-octanoic acid
  参考文献：
  名称：

  Efficient Phosphodiester Cleaving Nanozymes Resulting from Multivalency and Local Medium Polarity Control

  摘要：

  The self-organization of Zn(II) complexes on the surface of 1.6-nm diameter gold nanoparticles (nanozymes) allows the spontaneous formation of multiple bimetallic catalytic sites capable to promote the cleavage of a RNA model substrate. We show that by tuning the structure of the nanoparticle-coating monolayer, it is possible to decrease the polarity of the reaction site, and this in turn generates remarkable increments of the cleavage efficiency.

  DOI：

  10.1021/ja411969e

文献信息

• Separation material comprising saccharide ligands
  申请人：Gambro Lundia AB

  公开号：EP2556848A1

  公开（公告）日：2013-02-13

  The present disclosure relates to a separation material comprising a saccharide that is bound via a linker to a matrix for enabling the separation of substances from a liquid that selectively bind to saccharide moieties, to a method for preparing such material, to a method for separating substances from a liquid that selectively bind to saccharides, and to a device comprising a separation material for separating substances from a liquid that selectively bind to saccharides.

  本公开涉及一种分离材料，该材料包括通过连接剂与基质结合的糖，用于从液体中分离选择性结合糖分子的物质；本公开还涉及制备这种材料的方法、从液体中分离选择性结合糖分子的物质的方法，以及包含用于从液体中分离选择性结合糖分子的物质的分离材料的装置。
• Separation material
  申请人：Gambro Lundia AB

  公开号：EP2556849A1

  公开（公告）日：2013-02-13

  The present disclosure relates to a separation material comprising a matrix that is bound to a saccharide, enabling the separation from a liquid of substances that selectively bind the saccharide, to a method for preparing such separation material and a method for separating substances from a liquid that selectively bind a saccharide of the separation material. The present invention further relates to a device comprising a separation material for separating substances from a liquid that selectively bind to the saccharide of the separation material.

  本发明涉及一种分离材料，该材料包括一种与糖结合的基质，能够从液体中分离出选择性结合糖的物质；本发明还涉及制备这种分离材料的方法，以及从液体中分离选择性结合分离材料糖的物质的方法。本发明还涉及一种装置，该装置包含一种分离材料，用于从液体中分离选择性结合分离材料糖苷的物质。
• SEPARATION MATERIAL COMPRISING SACCHARIDE LIGANDS
  申请人：Gambro Lundia AB

  公开号：EP2741795A1

  公开（公告）日：2014-06-18
• SEPARATION MATERIAL
  申请人：Gambro Lundia AB

  公开号：EP2741796A1

  公开（公告）日：2014-06-18
• US9844621B2
  申请人：——

  公开号：US9844621B2

  公开（公告）日：2017-12-19