(5R)-5-methyl-1-{[(2R)-2-methyl-5-oxo-pyrrolidin-1-yl]methyl}pyrrolidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (5R)-5-methyl-1-{[(2R)-2-methyl-5-oxo-pyrrolidin-1-yl]methyl}pyrrolidin-2-one
• 英文别名: (5R)-5-methyl-1-[[(2R)-2-methyl-5-oxopyrrolidin-1-yl]methyl]pyrrolidin-2-one
• 化学式: C₁₁H₁₈N₂O₂
• 分子量: 210.276
• InChiKey: XDMFCUVMISDNPY-RKDXNWHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (S)-(+)-5-羟甲基-2-吡咯烷酮对甲苯磺酸酯 在 三甲基氯硅烷 、 偶氮二异丁腈 、 三正丁基氢锡 、 sodium iodide 作用下， 以 乙二醇二甲醚 为溶剂， 反应 12.0h， 生成 (5R)-5-methyl-1-{[(2R)-2-methyl-5-oxo-pyrrolidin-1-yl]methyl}pyrrolidin-2-one
  参考文献：
  名称：

  An optimised synthetic approach to a chiral derivatising agent and the utilisation of a dimerisation reaction in the synthesis of a novel C2-symmetric diphosphine ligand

  摘要：

  We report an optimised synthetic approach to the chiral derivatising agent (5R)-methyl-1-(chloromethyl)-2-pyrrolidinone. In addition, the observation of an unwanted dimerisation product is turned to our advantage by providing a method for the synthesis of a new class of C2-symmetric chiral diphosphine. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.02.014

文献信息

• An optimised synthetic approach to a chiral derivatising agent and the utilisation of a dimerisation reaction in the synthesis of a novel C2-symmetric diphosphine ligand
  作者：Glynn D. Williams、Charles E. Wade、Guy J. Clarkson、Martin Wills

  DOI：10.1016/j.tetasy.2007.02.014

  日期：2007.3

  We report an optimised synthetic approach to the chiral derivatising agent (5R)-methyl-1-(chloromethyl)-2-pyrrolidinone. In addition, the observation of an unwanted dimerisation product is turned to our advantage by providing a method for the synthesis of a new class of C2-symmetric chiral diphosphine. (c) 2007 Elsevier Ltd. All rights reserved.